Abstract:Electrochemical biosensors utilizing nanomaterials have received widespread attention in pathogen detection and monitoring. Here, the potential of different nanomaterials and electrochemical technologies is reviewed for the development of novel diagnostic devices for the detection of foodborne pathogens and their biomarkers. The overview covers basic electrochemical methods and means for electrode functionalization, utilization of nanomaterials that include quantum dots, gold, silver and magnetic nanoparticles… Show more
“…Electrochemical detection methods can be categorized into the following three major categories based on the measured property; i) amperometry or voltammetry method, (measurement of current) ii) potentiometric method, (measurement of potential) and iii) impendence method (resistance and/or conductance measurement) as showed in Fig. 6 ( Bobrinetskiy et al, 2021 ). Fig.…”
Section: Electroanalytical Methods For Sensing Sars-cov-2mentioning
confidence: 99%
“…[Adopted from Ref. ( Bobrinetskiy et al, 2021 ), Copyright 2021, by the authors, Licensee MDPI, Basel]. …”
Section: Electroanalytical Methods For Sensing Sars-cov-2mentioning
“…Electrochemical detection methods can be categorized into the following three major categories based on the measured property; i) amperometry or voltammetry method, (measurement of current) ii) potentiometric method, (measurement of potential) and iii) impendence method (resistance and/or conductance measurement) as showed in Fig. 6 ( Bobrinetskiy et al, 2021 ). Fig.…”
Section: Electroanalytical Methods For Sensing Sars-cov-2mentioning
confidence: 99%
“…[Adopted from Ref. ( Bobrinetskiy et al, 2021 ), Copyright 2021, by the authors, Licensee MDPI, Basel]. …”
Section: Electroanalytical Methods For Sensing Sars-cov-2mentioning
“…Furthermore, potentiometry sensors detect molecules by calculating the variation in potentials induced by applying a constant electric current. Lastly, impedance sensors works by measuring electric impedance resulting from applying alternating electric potentials [34]. Concerning the sampling methods, biological materials can be collected from the ISF by means of negative pressure (i.e., vacuum), capillary force, or material absorption.…”
Parkinson’s disease (PD) is a neurodegenerative disorder associated with widespread aggregation of α-synuclein and dopaminergic neuronal loss in the substantia nigra pars compacta. As a result, striatal dopaminergic denervation leads to functional changes in the cortico-basal-ganglia-thalamo-cortical loop, which in turn cause most of the parkinsonian signs and symptoms. Despite tremendous advances in the field in the last two decades, the overall management (i.e., diagnosis and follow-up) of patients with PD remains largely based on clinical procedures. Accordingly, a relevant advance in the field would require the development of innovative biomarkers for PD. Recently, the development of miniaturized electrochemical sensors has opened new opportunities in the clinical management of PD thanks to wearable devices able to detect specific biological molecules from various body fluids. We here first summarize the main wearable electrochemical technologies currently available and their possible use as medical devices. Then, we critically discuss the possible strengths and weaknesses of wearable electrochemical devices in the management of chronic diseases including PD. Finally, we speculate about possible future applications of wearable electrochemical sensors in PD, such as the attractive opportunity for personalized closed-loop therapeutic approaches.
“…Nanomaterials have been applied in different fields such as electrochemistry [ 1 , 2 , 3 ], medicine [ 4 , 5 ], engineering [ 6 ], and many others [ 7 , 8 ]. The physical and chemical properties of nanomaterials change depending on their composition, shape, and size, and thanks to their tunable characteristics, they are increasingly used to improve the performance of electrochemical sensors [ 9 , 10 , 11 ].…”
Nanomaterials can be used to modify electrodes and improve the conductivity and the performance of electrochemical sensors. Among various nanomaterials, gold-based nanostructures have been used as an anchoring platform for the functionalization of biosensor surfaces. One of the main advantages of using gold for the modification of electrodes is its great affinity for thiol-containing molecules, such as proteins, forming a strong Au-S bond. In this work, we present an impedimetric biosensor based on gold nanoparticles and a truncated aptamer for the quantification of gluten in hydrolyzed matrices such as beer and soy sauce. A good relationship between the Rct values and PWG-Gliadin concentration was found in the range between 0.1–1 mg L−1 of gliadin (corresponding to 0.2–2 mg L−1 of gluten) with a limit of detection of 0.05 mg L−1 of gliadin (corresponding to 0.1 mg L−1 of gluten). The label-free assay was also successfully applied for the determination of real food samples.
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