Recent advance in research on halloysite nanotubes-polymer nanocomposite

Liu, Mingxian; Jia, Zhixin; Jia, Demin; Zhou, Changren

doi:10.1016/j.progpolymsci.2014.04.004

Cited by 813 publications

(518 citation statements)

References 142 publications

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“…5,6 Halloysite is a natural aluminosilicate clay with a predominantly hollow tubular structure (HNT); it is chemically similar to platy kaolin (Al 2 Si 2 O 5 (OH) 4 ), which shows excellent bio- 7,8 and ecocompatibility. 9,10 Halloysite is positively charged in the inner lumen, which consists mostly of aluminum hydroxide, whereas the external surface, which consists of silicon dioxide, 11 is negatively charged. The different surface chemistry allows selective functionalization of the inner or outer surfaces, enabling the synthesis of nanomaterials with hierarchical nanostructures.…”

Section: Introductionmentioning

confidence: 99%

Hybrid supramolecular gels of Fmoc-F/halloysite nanotubes: systems for sustained release of camptothecin

et al. 2017

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show that f-HNT functions only as an additive in the hybrid gels and does not demonstrate gelator behavior. The in vitro kinetic release from both f-HNT/CPT and Fmoc-F/f-HNT/CPT was studied in media that imitates physiological conditions, and the factors controlling the release process were determined and discussed. Furthermore, the antiproliferative in vitro activities of the gels were evaluated towards human cervical cancer HeLa cells. A comparison of data collected in both systems shows the synergistic action of f-HNT and the gel matrix in controlling the release of CPT in the media and maintaining the drug in its active form. Finally, a comparison with pristine HNT is also reported. This study suggests a suitable strategy to obtain two-component gel hybrids based on nanocarriers with controlled drug carrier capacity for biomedical applications.

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Section: Introductionmentioning

confidence: 99%

Hybrid supramolecular gels of Fmoc-F/halloysite nanotubes: systems for sustained release of camptothecin

et al. 2017

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“…The authors concluded that the mechanical properties of HNT/PHBV composites could be altered with the final composition dependent on the clay organomodifier [32]. Furthermore, silane-functionalized HNTs have been developed for many applications in polymer matrices, such as epoxy resin [33], polypropylene [31], natural rubber [34], and ethylene-propylene-diene rubber [35].…”

Section: Introductionmentioning

confidence: 99%

“…Furthermore, the addition of fluorescein isothiocyanate (FITC) to the surface creates a method by which the effectiveness of the targeted system can be determined via in vivo imaging [16]. Additionally, this study describes a washing process for the HNTs, post modification, that is not reported in similar studies [24,33,37,[42][43][44][45]. The resulting modified HNTs were characterized via FTIR, 13C{H1}CPMAS NMR, and UV-Vis spectroscopy.…”

Section: Introductionmentioning

confidence: 99%

Bi-Functionalized Clay Nanotubes for Anti-Cancer Therapy

et al. 2018

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Systemic toxicity is an undesired consequence of the majority of chemotherapeutic drugs. Multifunctional nanoparticles with combined diagnostic and therapeutic functions show great promise towards personalized nanomedicine. Halloysite clay nanotubes (HNTs) have shown potential as a drug delivery vehicle, and its surface can be modified and tailored as a targeted drug delivery system. In this short report, we modified the HNT surface by covalently bonding folic acid (FA) and fluorescein isothiocyanate (FITC). The modification of HNTs with folic acid imparts the potential to target tumor cells selectively. The addition of FITC offers a method for quantifying the effectiveness of the FA tagged HNTs ability to target tumor cells. We documented cell uptake of our bi-functionalized HNT (bHNT) through phase contrast and epi-fluorescent microscopy. bHNTs showed no signs of cytotoxicity up to a concentration of 150 µg/mL. The increase in cell death with increased bHNT concentration may be due to induced cytotoxicity resulting from intracellular bHNT accumulation that disrupts cellular function leading to cell death. With HNTs recognized as having the ability to serve as both a nanocontainer and nanocarrier, we envision our construct as a potential modular platform for potential use in cancer therapeutics. The HNT interior can be loaded with a variety of anti-cancer drugs (or other chemotherapeutics) and serve as a "death cargo" designed to kill cancer cells while providing feedback imaging data on drug efficacy. The surface of the HNT can be modified with gold or silver nanoparticles and used in photothermal therapy by converting light to heat inside tumors. Our HNT-based drug delivery system has the potential to provide localized and targeted therapies that limit or reduce side effects, reduce patient costs and length of hospital stays, and improve quality of life. However, further research is needed to validate the potential of this new chemotherapeutic drug delivery system.

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“…They are known to improve the mechanical properties of epoxy composites after proper surface modification, and lack of surface modification can lead to poor nanotube dispersion and inefficient stress transfer [2]. Moreover, poor load transfer between the HNTs and the surrounding polymer chains can cause interfacial slippage, leading to deteriorated mechanical properties of the composites [10]. Therefore, optimizing the HNT surface is essential to enhance the properties of the nanocomposites.…”

Section: Introductionmentioning

confidence: 99%

Mechanical and Thermal Properties of Epoxy Composites Containing Zirconium Oxide Impregnated Halloysite Nanotubes

Kim

et al. 2017

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Liquid epoxy resins have received much attention from both academia and the chemical industry as eco-friendly volatile organic compound (VOC)-free alternatives for applications in coatings and adhesives, especially in those used in households. Epoxy resins show high chemical resistance and high creep resistance. However, due to their brittleness and lack of thermal stability, additional fillers are needed for improving the mechanical and thermal properties. Halloysite nanotubes (HNTs) are naturally abundant, inexpensive, and eco-friendly clay minerals that are known to improve the mechanical and thermal properties of epoxy composites after suitable surface modification. Zirconium is well known for its high resistance to heat and wear. In this work, zirconium oxide-impregnated HNTs (Zr/HNTs) were added to epoxy resins to obtain epoxy composites with improved mechanical and thermal properties. Zr/HNTs were characterized by field-emission transmission electron microscopy, transmission electron microscopy with energy-dispersive X-ray spectroscopy, X-ray diffraction, and X-ray photoelectron spectroscopy. Changes in the thermal properties of the epoxy composites were characterized by thermo mechanical analysis and differential scanning calorimetry. Furthermore, flexural properties of the composites were analyzed using a universal testing machine.

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Recent advance in research on halloysite nanotubes-polymer nanocomposite

Cited by 813 publications

References 142 publications

Hybrid supramolecular gels of Fmoc-F/halloysite nanotubes: systems for sustained release of camptothecin

Hybrid supramolecular gels of Fmoc-F/halloysite nanotubes: systems for sustained release of camptothecin

Bi-Functionalized Clay Nanotubes for Anti-Cancer Therapy

Mechanical and Thermal Properties of Epoxy Composites Containing Zirconium Oxide Impregnated Halloysite Nanotubes

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