Realization of 1 million pixel charge transfer type ion image sensor with 12 &amp;#x00B5;m pixel pitch

Futagawa, Masato; Otake, Ryota; Dasai, Fumihiro; Ishida, M.; Sawada, Kazuaki

doi:10.1109/transducers.2015.7180905

Cited by 3 publications

(3 citation statements)

References 17 publications

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“…Several papers integrated active pixel sensors (APS) using ISFETs by employing the ISFETs as the standard buffer [ 175 , 176 ] or the replacement of the photodiode by the ISFET [ 164 , 165 ] (by using a charge transfer technique). Huang et al [ 176 ] proposed a dual-mode sensor by integrating a CMOS image sensor with the ISFET as the standard buffer to achieve accurate pH detection towards DNA sequencing.…”

Section: Readout Circuit and Systemsmentioning

confidence: 99%

Recent Advances of Field-Effect Transistor Technology for Infectious Diseases

et al. 2021

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Field-effect transistor (FET) biosensors have been intensively researched toward label-free biomolecule sensing for different disease screening applications. High sensitivity, incredible miniaturization capability, promising extremely low minimum limit of detection (LoD) at the molecular level, integration with complementary metal oxide semiconductor (CMOS) technology and last but not least label-free operation were amongst the predominant motives for highlighting these sensors in the biosensor community. Although there are various diseases targeted by FET sensors for detection, infectious diseases are still the most demanding sector that needs higher precision in detection and integration for the realization of the diagnosis at the point of care (PoC). The COVID-19 pandemic, nevertheless, was an example of the escalated situation in terms of worldwide desperate need for fast, specific and reliable home test PoC devices for the timely screening of huge numbers of people to restrict the disease from further spread. This need spawned a wave of innovative approaches for early detection of COVID-19 antibodies in human swab or blood amongst which the FET biosensing gained much more attention due to their extraordinary LoD down to femtomolar (fM) with the comparatively faster response time. As the FET sensors are promising novel PoC devices with application in early diagnosis of various diseases and especially infectious diseases, in this research, we have reviewed the recent progress on developing FET sensors for infectious diseases diagnosis accompanied with a thorough discussion on the structure of Chem/BioFET sensors and the readout circuitry for output signal processing. This approach would help engineers and biologists to gain enough knowledge to initiate their design for accelerated innovations in response to the need for more efficient management of infectious diseases like COVID-19.

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Section: Readout Circuit and Systemsmentioning

confidence: 99%

Recent Advances of Field-Effect Transistor Technology for Infectious Diseases

et al. 2021

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“…An input diode and an input control gate are used to fill the potential well with charge, and then a floating diffusion and a transfer gate are used to transfer the charge to be measured. The number of pixels and their density have been increased: 32 × 32 pixels with a pitch of 130 μm, (29) 128 × 128 pixels with a pitch of 23 μm, (30) and 1024 × 1024 pixels with a pitch of 12.1 μm (31) have been reported. In addition to pH, the concentration of other ions such as K + (29) and Na + (32) and biomolecules such as acetylcholine (33,34) have been measured by modifying of the sensor area.…”

Section: Ccd/cmos-based Ph Imaging Sensormentioning

confidence: 99%

Development and Bio-imaging Applications of a Chemical Imaging Sensor

2016

Sensors and Materials

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A chemical imaging sensor is a field-effect-based semiconductor sensor, capable of label-free imaging of ion distributions in a solution. The sensor has attracted much interest owing to its simple structure and diverse fields of application of bioimaging. In this article, the principle and development of the chemical imaging sensor are summarized, compared with those of other labelfree imaging sensors. Bio-imaging applications of the chemical imaging sensor to ion diffusion, enzymatic reaction, and metabolic activities of microorganisms are also reviewed.

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“…Since its first implementation in standard CMOS technology back in 1999 [9], ISFET have looked for inspiration in fields with shared requirements and challenges, such as CMOS imagers, leading to a fruitful innovation transfer. Examples of this inspiration are the implementation of an APS-inspired architecture [10] or the recent trend towards ultra-high frame rate chemical imagers [11]. Furthermore, ISFET application requirements are driving the in-pixel integration of multiple sensing modalities [12], [13], as well as the incorporation of computational capabilities to the sensing platform that provide processing and learning functionalities [14], [15].…”

Section: Introductionmentioning

confidence: 99%

A Digital ISFET Sensor with In-Pixel ADC

Han

Cacho-Soblechero

Douthwaite

et al. 2021

2021 IEEE International Symposium on Circuits and Systems (ISCAS)

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This paper presents a novel ISFET architecture with in-pixel ADC for large-scale integration and on-chip computational capabilities. Each pixel is composed by a comparator connected to a set of memory elements, storing in-pixel each conversion. Using this sensing scheme, the entire frame of ISFET pixels is acquired and stored in one single ADC cycle, eliminating the need for global or column-level ADCs and making this architecture scalable to larger arrays without instrumentation overhead. To enable compensation of ISFET non-idealities such as trapped charge, a novel gate-bootstrapping mechanism is introduced, enhancing the ADC dynamic range without additional circuitry and accommodating a trapped charge compensation range of 4.45 V. Fabricated in standard 180nm CMOS technology, the system is composed by a 16x16 ISFET array, a global DAC and a Digital Control Unit that enables operation and off-chip communication. The entire frame is acquired in 51.2 µs with a pixel power consumption of 10.15 µW , while storing the result in-pixel and eliminating the need for off-chip memories.

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Realization of 1 million pixel charge transfer type ion image sensor with 12 µm pixel pitch

Cited by 3 publications

References 17 publications

Recent Advances of Field-Effect Transistor Technology for Infectious Diseases

Recent Advances of Field-Effect Transistor Technology for Infectious Diseases

Development and Bio-imaging Applications of a Chemical Imaging Sensor

A Digital ISFET Sensor with In-Pixel ADC

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