Development and Bio-imaging Applications of a Chemical Imaging Sensor

Abstract

A chemical imaging sensor is a field-effect-based semiconductor sensor, capable of label-free imaging of ion distributions in a solution. The sensor has attracted much interest owing to its simple structure and diverse fields of application of bioimaging. In this article, the principle and development of the chemical imaging sensor are summarized, compared with those of other labelfree imaging sensors. Bio-imaging applications of the chemical imaging sensor to ion diffusion, enzymatic reaction, and metabolic activities of microorganisms are also reviewed.

Simultaneous In Situ Imaging of pH and Surface Roughening during the Progress of Crevice Corrosion of Stainless Steel

“…Recently, we proposed the label-free measurement of pH distribution inside a crevice [ 9 , 10 , 11 ] by applying a semiconductor-based chemical imaging sensor [ 12 ], which was based on the principle of the light-addressable potentiometric sensor (LAPS, [ 13 , 14 ]). Figure 1 a shows a schematic view of a LAPS sensor plate.…”