Real-time monitoring of human blood clotting using a lateral excited film bulk acoustic resonator

Chen, Da; Wang, Jingjng; Wang, Peng; Guo, Qiuquan; Zhang, Zhen; Ma, Jilong

doi:10.1088/1361-6439/aa5bbe

Cited by 11 publications

(5 citation statements)

References 39 publications

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“…According to clinical guidance, INR of the patient is the primary clinical indication for the therapy with warfarin or related oral anticoagulants. The safety and effectiveness of warfarin depends on keeping the INR within the target range, which is usually 2.0–3.0 [ 2 , 36 ]. Figure 10 shows the INR values of the patient and a healthy donor measured by different methods.…”

Section: Resultsmentioning

confidence: 99%

“…Based on this method, the lateral excited FBAR devices show significantly improved performances in viscous media. We have reported the lateral excited FBAR as a viscosity sensor for the blood coagulation measurements [ 35 , 36 , 37 ]. However, an obvious shortcoming of this method is the relatively weak electric field between the electrodes with the gap of several microns, resulting in a very low electromechanical coupling [ 38 ] (see Supplementary Material ).…”

Section: Introductionmentioning

confidence: 99%

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Shear Mode Bulk Acoustic Resonator Based on Inclined c-Axis AlN Film for Monitoring of Human Hemostatic Parameters

et al. 2018

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Measurement of hemostatic parameters is essential for patients receiving long-term oral anticoagulant agents. In this paper, we present a shear mode bulk acoustic resonator based on an inclined c-axis aluminum nitride (AlN) film for monitoring the human hemostatic parameters. During the blood coagulation process, the resonant frequency of the device decreases along with a step-ladder profile due to the viscosity change during the formation of fibers in blood, revealing the sequential coagulation stages. Two hemostatic parameters with clinical significance, prothrombin time (PT) along with its derived measure of international normalized ratio (INR), are determined from time-frequency curves of the device. Furthermore, the resonator is compared with a commercial coagulometer by monitoring the hemostatic parameters for one month in a patient taking the oral anticoagulant. The results are consistent. In addition, thanks to the excellent potential for integration, miniaturization and the availability of direct digital signals, the proposed device has promising application for point of care coagulation monitoring.

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Section: Resultsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Shear Mode Bulk Acoustic Resonator Based on Inclined c-Axis AlN Film for Monitoring of Human Hemostatic Parameters

et al. 2018

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“…[ 54 ] Moreover, real‐time monitoring of blood clotting and measurement of hemostatic parameters can be achieved by a micro‐fabricated film bulk acoustic sensor. [ 55 ] The device was made of an Au/ZnO/Si 3 N 4 film stack exciting by a lateral electric field. It operated under a shear mode by recording the resonant frequency variation along with the change of blood viscosity to reveal the sequential clotting stages.…”

Section: Design Principles Of Microfluidic Devices For Coagulation Researchmentioning

confidence: 99%

Microfluidic systems toward blood hemostasis monitoring and thrombosis diagnosis: From design principles to micro/nano fabrication technologies

Nie

et al. 2022

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Perfusable endothelialized models of microfluidic systems that recapitulate unique biological and biophysical microvasculature conditions are improved with micro/nano engineering advances for monitoring of blood hemostasis and thrombosis treatment. Although bio‐sensors and monitoring devices significantly advance in measuring platelet aggregation and thrombosis kinetics, currently platelet aggregation tests still do not meet the arising clinical requirements. Trying to seek new solutions for such a demanding from clinics, the present review provides an overview of design principles of microfluidic systems and micro/nano fabrication strategies in studying the platelet adhesion and aggregation. We critically sketch the characteristics of microfluidic systems to elucidate the role of platelets in the complex process of thrombus formation. The importance, benefits, and challenges of introduced principles and methods are discussed. The potential from various of basic research to clinical applications is also briefly discussed to help guide designing more versatile point‐of‐care devices for hemostasis monitoring and thrombosis diagnosis and treatment.

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“…Up to now, the film electroacoustic resonators have been employed for gas [27][28][29][30] and biomolecular detections [31][32][33]. However, they are rarely used to detect the disease biomarkers in clinical samples collected from real patients.…”

Section: Introductionmentioning

confidence: 99%

Detection of cardiac biomarkers in serum using a micro-electromechanical film electroacoustic resonator

Peng

Song

Niu

et al. 2020

J. Micromech. Microeng.

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Rapid, portable, and sensitive biosensors for the detection of cardiac biomarkers are important for early diagnosis of cardiovascular diseases. We demonstrate a micro-electromechanical film electroacoustic resonator for heart-type fatty acid-binding protein assays. This device combines an immunologic sensitive element with the resonator working in biological liquids. Based on the mass-sensitive mechanism, the immune reaction between the target antigens and antibodies was detected by monitoring the frequency change in real-time and the concentration of heart-type fatty acid-binding protein in serum was determined. A linear response in 0.02–10 ng ml−1 and a low detection limit of 0.014 ng ml−1 were achieved. Serum samples were collected from patients and used without any additional pre-treatment. The protein concentrations measured by the proposed device showed good linear correlation and consistency compared with standard laboratory methods. The results indicate that the proposed device is able to be a feasible tool for sensitive, rapid, and miniaturized point-of-care analytical systems.

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Real-time monitoring of human blood clotting using a lateral excited film bulk acoustic resonator

Cited by 11 publications

References 39 publications

Shear Mode Bulk Acoustic Resonator Based on Inclined c-Axis AlN Film for Monitoring of Human Hemostatic Parameters

Shear Mode Bulk Acoustic Resonator Based on Inclined c-Axis AlN Film for Monitoring of Human Hemostatic Parameters

Microfluidic systems toward blood hemostasis monitoring and thrombosis diagnosis: From design principles to micro/nano fabrication technologies

Detection of cardiac biomarkers in serum using a micro-electromechanical film electroacoustic resonator

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