Real time in vivo imaging and measurement of serine protease activity in the mouse hippocampus using a dedicated complementary metal-oxide semiconductor imaging device

Implantable CMOS biomedical devices

“…However, this is difficult for current measurement methods, such as functional magnetic resonance imaging (fMRI), positron emission tomography (PET), and near infrared spectroscopy (NIRS) to meet both of these requirements, as shown in Figure 14 [31]. We have developed a new CMOS-based imaging device with a sub-mm, sub-second spatiotemporal resolution and have successfully demonstrated monitoring of the time course of serine protease activities inside the mouse hippocampus [6][7][8][9]. Through appropriate packaging, the developed device can be used for arbitrary depth imaging inside the mouse brain with minimal impact on brain function.…”

“…In this review, two typical examples of implantable CMOS devices from our research are described: retinal prosthesis devices [1][2][3][4][5] and brain-implantable devices based on CMOS technologies [6][7][8][9]. In retinal prosthesis devices, MEMS technologies with CMOS circuits have been used to realize a retinal stimulator based on a microchip array, and in brain-implantable devices, image sensor technology and MEMS have been combined to realize an ultra-compact device to be implanted in the deep brain of experimental small animals.…”

CMOS Imaging Devices for Biomedical Applications

“…We have developed a CMOS-based bmp-LSI imaging device with a sub-millimeter/sub-second spatiotemporal resolution and have successfully demonstrated monitoring of the time course of serine protease activities inside the mouse hippocampus [10]- [13].…”

“…Two bioimaging devices are considered, namely, a dish-type imaging device for in vitro measurement [6] and a brainimplantable imaging device for in vivo measurement [10], [11]. A retinal prosthetic device is then introduced for medical applications [5], [14].…”

One-chip sensing device (biomedical photonic LSI) enabled to assess hippocampal steep and gradual up-regulated proteolytic activities

“…* resolution to observe images in deep brain regions, we previously developed prototype of complementary metal-oxide semiconductor (CMOS) sensor device (Ng et al, 2006). In the present study, we modified the device to produce a tiny multimodal device (biomedical photonic LSI; BpLSI), which integrates an imaging array and illumination light source.…”