CMOS Imaging Devices for Biomedical Applications

Ohta, Jun; Kobayashi, Takuma; Noda, Toshihiko; Sasagawa, Kiyotaka

doi:10.1587/transcom.e94.b.2454

Cited by 7 publications

(3 citation statements)

References 21 publications

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“…Furthermore, CMOS has the advantage of being a cost-effective commercial technology for production of large matrices. This makes SPADs manufactured in this technology ideal for different medical imaging applications [7]. In this work SPADs with multiplication layers buried at different depths have been studied with a focus on lower DCR and high PDE in the NIR region to target Diffusion Correlation Spectroscopy (DCS) applications.…”

Section: Introductionmentioning

confidence: 99%

Development of single photon avalanche detectors for NIR light detection

et al. 2022

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Near-infrared (NIR) light is used in several non-invasive biomedical techniques to measure the blood flow in deep tissues. The BIOSPAD project targets the development of SPAD arrays specifically designed for Diffuse Correlation Spectroscopy (DCS) in the NIR to measure deep tissue microvascular blood flow. In the first stage of the project, single SPADs with multiplication layers buried at different depths have been designed at IFAE and produced in a 150 nm CMOS technology. In this study, we present results of the characterization of SPAD devices with an area of 50 × 50 µm2 operated with an external passive quenching circuit. We compared properties, such as Dark Count Rate (DCR) and Photon Detection Efficiency (PDE) of the different SPAD designs. The PDE for 780 nm light of SPADs with a buried multiplication layer was observed to be in the range of 10–20% with a DCR of the order of 2 kHz. The results of these first prototypes are promising and are being followed up by the development of a new generation of CMOS SPADs designed to further improve the NIR light response.

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Section: Introductionmentioning

confidence: 99%

Development of single photon avalanche detectors for NIR light detection

et al. 2022

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“…We propose to use complementary metal-oxide-semiconductor (CMOS) image sensors for bioimaging. [7][8][9][10][11][12][13] Such sensors are suitable for detecting fluorescent beads because they can measure fluorescence and have high-resolution imaging functions. By using such sensors, the system becomes simple and small.…”

Section: Introductionmentioning

confidence: 99%

Complementary Metal–Oxide–Semiconductor Image Sensor with Microchamber Array for Fluorescent Bead Counting

Sasagawa

Ando

Kobayashi

et al. 2012

Jpn. J. Appl. Phys.

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We fabricated a complementary metal–oxide–semiconductor image sensor with a femtoliter microchamber array. The microchamber array plate is used for trapping microbeads and limiting the incident angle of light detected by the sensor. The sensor has an interference filter for fluorescent microbeads imaging. We detected fluorescent and nonfluorescent microbead with this sensor and showed its capability for counting the number of fluorescent chambers.

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“…Several instruments that photostimulate neurons in the brain with optogenetics have recently been developed 7 8 9 , in addition to several functional brain-imaging techniques 10 11 12 13 14 . Micro complementary-metal-oxide-semiconductor (CMOS) image sensors enable less invasive imaging in living tissue 15 16 17 18 19 20 21 . Previous studies have demonstrated that a fluorescence imaging system enables potentiometry in primary cultured neurons and in the brain with multiple sensors 22 23 24 25 .…”

mentioning

confidence: 99%

“Optical communication with brain cells by means of an implanted duplex micro-device with optogenetics and Ca2+ fluoroimaging”

Kobayashi

Haruta

Sasagawa

et al. 2016

Sci Rep

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To better understand the brain function based on neural activity, a minimally invasive analysis technology in a freely moving animal is necessary. Such technology would provide new knowledge in neuroscience and contribute to regenerative medical techniques and prosthetics care. An application that combines optogenetics for voluntarily stimulating nerves, imaging to visualize neural activity, and a wearable micro-instrument for implantation into the brain could meet the abovementioned demand. To this end, a micro-device that can be applied to the brain less invasively and a system for controlling the device has been newly developed in this study. Since the novel implantable device has dual LEDs and a CMOS image sensor, photostimulation and fluorescence imaging can be performed simultaneously. The device enables bidirectional communication with the brain by means of light. In the present study, the device was evaluated in an in vitro experiment using a new on-chip 3D neuroculture with an extracellular matrix gel and an in vivo experiment involving regenerative medical transplantation and gene delivery to the brain by using both photosensitive channel and fluorescent Ca2+ indicator. The device succeeded in activating cells locally by selective photostimulation, and the physiological Ca2+ dynamics of neural cells were visualized simultaneously by fluorescence imaging.

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CMOS Imaging Devices for Biomedical Applications

Cited by 7 publications

References 21 publications

Development of single photon avalanche detectors for NIR light detection

Development of single photon avalanche detectors for NIR light detection

Complementary Metal–Oxide–Semiconductor Image Sensor with Microchamber Array for Fluorescent Bead Counting

“Optical communication with brain cells by means of an implanted duplex micro-device with optogenetics and Ca2+ fluoroimaging”

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