Implantable CMOS biomedical devices

Abstract

Abstract:The results of recent research on our implantable CMOS biomedical devices are reviewed. Topics include retinal prosthesis devices and deep-brain implantation devices for small animals. Fundamental device structures and characteristics as well as in vivo experiments are presented.

CMOS Imaging Devices for Biomedical Applications

“…Investigating the neural activities of small animals, such as a mouse, without tethering, is difficult using currently available measurement tools such as functional magnetic resonance imaging (fMRI), positron emission tomography (PET), and functional near infrared spectrometer (fNIRS)/optical tomography. In order to address this problem, several devices have been developed [1], [2]. However, the observation of neural activities in the deep mouse brain using these devices remains difficult.…”

“…Previously, fluorescence was measured using an optical microscope in conjunction with an image sensor. Recently, another configuration has emerged, in which bio-materials or living tissues containing fluorophores are in direct contact with the surface of an image sensor, which allows more compact measurement systems to be realized [2]. Such a compact system can also be implanted into a living body.…”

“…In developing such biomedical devices, we face several challenges, as shown in Fig. 2 [2]. The surface of the device can affect living tissues or cells, and these effects can include cytotoxicity.…”

Distributed Sensing of Fluid Dynamic Phenomena with the XDense Sensor Grid Network

“…For example, flow control on aircrafts [2] and under-water vehicles [3]. There are many other application examples for such deployments ranging from artificial skins for robotics [4], to biomedical devices such as implantable prosthesis [5]. In this paper we focus on fluid dynamic phenomena, which have tight spatial and temporal sensing requirements [2].…”

Micro CMOS image sensor for multi-area imaging

“…Implantable complementary-metal-oxide-semiconductor (CMOS) image sensors are micro image sensors for fluorescence imaging in a living tissue, which would be able to solve the issues above [4]- [9]. Although the sensors have invasiveness a little, they can be implanted in a brain of mouse and f1uoresence imaging can be carried out even when the mouse is moving freely.…”