Reactive oxygen species-sensitive thioketal-linked mesoporous silica nanoparticles as drug carrier for effective antibacterial activity

Li, Jinsong; Ding, Zhiyu; Li, Yuezhan; Miao, Jun; Wang, Weiguo; Nundlall, Keshav; Chen, Shijie

doi:10.1016/j.matdes.2020.109021

Cited by 48 publications

(38 citation statements)

References 37 publications

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“…The bactericidal potential of ZnO/TiO 2 /AgNCs was determined by live/dead assay using SYTO 9, a green fluorescent dye that could bind all the viable and dead bacterial cells, and PI, a red fluorescent dye that specifically binds to the nucleic acids of damaged bacterial cells [ 35 ]. The bacterial cells of S. aureus and E. coli without any treatment were observed on the green and the green:red merged channels that emit a green colour, confirming that the cells were healthy and viable ( Figure 8 a,c).…”

Section: Resultsmentioning

confidence: 99%

Facile In-Situ Fabrication of a Ternary ZnO/TiO2/Ag Nanocomposite for Enhanced Bactericidal and Biocompatibility Properties

et al. 2021

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This paper presents for the first time a successful fabrication of ternary ZnO/TiO2/Ag nanocomposites consisting of zinc oxide (ZnO), titania (TiO2) and silver (Ag) nanoparticles (NPs) synthesised using Morinda citrifolia fruit (MCF) extract. ZnONPs were synthesised using the co-precipitation method, and TiO2 and Ag were introduced into the precursor solutions under microwave irradiation to obtain ZnO/TiO2/Ag nanocomposites (NCs). This material demonstrated enhanced bactericidal effect towards bacterial pathogens compared to that of the binary TiO2/Ag, Ag and TiO2 alone. In vitro cytotoxicity results of the as-synthesised ZnO/TiO2/AgNCs on RAW 264.7 macrophages and A549 cell lines revealed a negative role in cytotoxicity, but contributed astoundingly towards antimicrobials as compared of Ag alone and binary Ag/TiO2. This study shows that the resultant ternary metal/bi-semiconductor nanocomposites may provide a therapeutic strategy for the eradication of bacterial pathogens without affecting the healthy mammalian cells.

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Section: Resultsmentioning

confidence: 99%

Facile In-Situ Fabrication of a Ternary ZnO/TiO2/Ag Nanocomposite for Enhanced Bactericidal and Biocompatibility Properties

et al. 2021

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“…34 ). 771 The interaction with the ROS-rich microenvironment results in the cleavage of the TK linker and degradation of the surface polymer, triggering pore uncapping and VAN release. In vitro evaluation of the antimicrobial efficiency demonstrated that, compared to VAN directly loaded into MSNs, the full nanosystem exhibited remarkably better controlled release and antibacterial activity against S. aureus due to the strong influence on the bacterial membrane's disintegration.…”

Section: Potential Biomedical Treatments Using Msnsmentioning

confidence: 99%

Engineering mesoporous silica nanoparticles for drug delivery: where are we after two decades?

et al. 2022

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“…In vivo studies in a mouse model of lethal pneumonic tularemia showed that the nanosystem prevented weight loss, illness and death, noticeably reducing the burden of F. tularensis in the lung, liver and spleen and showed higher efficacy than a comparable amount of free antibiotic. and hydroxyl radical (-OH) [92]. Free oxygen radicals are highly toxic to pathogens and they are used as a powerful tool to prevent colonization of tissues by pathogenic microorganisms [93].…”

Section: Redox Potentialmentioning

confidence: 99%

Targeted Stimuli-Responsive Mesoporous Silica Nanoparticles for Bacterial Infection Treatment

Colilla

Vallet‐Regí

2020

IJMS

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The rise of antibiotic resistance and the growing number of biofilm-related infections make bacterial infections a serious threat for global human health. Nanomedicine has entered into this scenario by bringing new alternatives to design and develop effective antimicrobial nanoweapons to fight against bacterial infection. Among them, mesoporous silica nanoparticles (MSNs) exhibit unique characteristics that make them ideal nanocarriers to load, protect and transport antimicrobial cargoes to the target bacteria and/or biofilm, and release them in response to certain stimuli. The combination of infection-targeting and stimuli-responsive drug delivery capabilities aims to increase the specificity and efficacy of antimicrobial treatment and prevent undesirable side effects, becoming a ground-breaking alternative to conventional antibiotic treatments. This review focuses on the scientific advances developed to date in MSNs for infection-targeted stimuli-responsive antimicrobials delivery. The targeting strategies for specific recognition of bacteria are detailed. Moreover, the possibility of incorporating anti-biofilm agents with MSNs aimed at promoting biofilm penetrability is overviewed. Finally, a comprehensive description of the different scientific approaches for the design and development of smart MSNs able to release the antimicrobial payloads at the infection site in response to internal or external stimuli is provided.

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Reactive oxygen species-sensitive thioketal-linked mesoporous silica nanoparticles as drug carrier for effective antibacterial activity

Cited by 48 publications

References 37 publications

Facile In-Situ Fabrication of a Ternary ZnO/TiO2/Ag Nanocomposite for Enhanced Bactericidal and Biocompatibility Properties

Facile In-Situ Fabrication of a Ternary ZnO/TiO2/Ag Nanocomposite for Enhanced Bactericidal and Biocompatibility Properties

Engineering mesoporous silica nanoparticles for drug delivery: where are we after two decades?

Targeted Stimuli-Responsive Mesoporous Silica Nanoparticles for Bacterial Infection Treatment

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