Reactive oxygen species and chemokines: Are they elevated in the esophageal mucosa of children with gastroesophageal reflux disease?

Tutar, Engin; Ertem, Deniz; Ünlügüzel, Göksenin; Tanrikulu, Sevda; Haklar, Goncagül; Çelikel, Çiğdem; Ademoğlu, Evin; Pehlivanoğlu, Ender

doi:10.3748/wjg.14.3218

Cited by 3 publications

(3 citation statements)

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“…These alterations were partially associated with histomorphological alterations characteristic of GERD, such as DIS and BCH 12 . As previously shown in the same study population, 31 and by other investigators, 34–38 both NERD and ERD are characterized by mucosal infiltration by immune cells (mostly lymphocytes); induction of the Th1‐type cytokines interleukin (IL)‐1β and IL‐8 31,34–36 and their receptors; 37 and the activation of several other pathways/mediators, such as NFκB, 34,38 PAR‐2, 39 reactive oxygen species (ROS), and iNOS 40–42 . In animal models, the pathophysiological role of acidified and/or bile‐containing refluxate in histomorphological changes (DIS and BCH) and the activation of inflammatory mediators has been demonstrated 43–45 .…”

Section: Discussionmentioning

confidence: 55%

Gastro‐oesophageal reflux disease is associated with up‐regulation of desmosomal components in oesophageal mucosa

et al. 2012

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Section: Discussionmentioning

confidence: 55%

Gastro‐oesophageal reflux disease is associated with up‐regulation of desmosomal components in oesophageal mucosa

et al. 2012

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“…is observation suggests that GE treatment can be effective against acute reflux esophagitis by promoting mucus secretion ( Figure 5). e production of ROS causes cellular damage, and it has been reported to play a role in the pathogenesis of various gastrointestinal diseases [35,36]. ROS produced by gastric reflux has been shown to cause damage to the esophagus, and these results suggest that the antioxidant activity can prevent tissue damage [37].…”

Section: Resultsmentioning

confidence: 99%

Improvement of Inflammation through Antioxidant Pathway of Gardeniae Fructus 50% EtOH Extract (GE) from Acute Reflux Esophagitis Rats

Kim

Shin

Lee

et al. 2020

BioMed Research International

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Gardeniae Fructus 50% EtOH extract (GE) is a traditional herb that has been used to treat a variety of diseases. In this study, we investigate the antioxidant, anti-inflammatory, and antiapoptotic properties of GE on acute reflux-induced esophagitis (RE) model in rats. 2,2′-Azino-bis (3-ethylbenzothiazolin-6-sulfonic acid) (ABTS) and 2,2-diphenyl-1-picrylhydrazyl (DPPH) radical scavenging assays were performed to determine the antioxidant activity of GE. GE was given orally at 50 and 100 mg/kg body weight 1h 30 min prior to RE induction. And its effect was assessed in comparison with RE control and normal groups. The administration of the extract of the GE showed remarkable protection of mucosal damage in esophageal tissue, and the histologic observation showed that the gastric lesion was improved. Increased reactive oxygen species (ROS) levels in the serum were diminished by GE treatment. The antioxidative biomarkers including nuclear factor-erythroid 2-related factor 2 (Nrf-2), heme oxygenase-1 (HO-1), superoxide dismutase (SOD), catalase, and glutathione peroxidase (GPX) were significantly increased. GE administration significantly reduced the inflammatory protein expression through MAPK-related signaling pathways and the nuclear factor-kappa B (NF-κB) pathway. These results suggest that GE protects the esophagus mucosal membrane by attenuating oxidative stress and inflammatory response under reflux esophagitis condition through the antioxidant pathway. Therefore, it is suggested that GE may be a potential remedy for the treatment of reflux esophagitis.

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“…ROS were reported to play a role in the pathogenesis of several gastrointestinal diseases such as inflammatory bowel disease and peptic ulcer [ 9 ]. ROS generated in the process of reflux esophagitis were found to be responsible for esophageal tissue damage [ 36 ], and this finding was further supported by studies showing that tissue damage could be prevented by the antioxidant activity.…”

Section: Discussionmentioning

confidence: 99%

Protective effect of Rhei Rhizoma on reflux esophagitis in rats via Nrf2-mediated inhibition of NF-κB signaling pathway

Kwon

Choo

Lee

et al. 2015

BMC Complement Altern Med

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BackgroundRhei Rhizoma has been widely used as a traditional herbal medicine to treat various inflammatory diseases. The present study was conducted to evaluate its anti-inflammatory activity against experimental reflux-induced esophagitis (RE) in SD rats.MethodsRhei Rhizoma was administered at 125 or 250 mg/kg body weight per day for 7 days prior to the induction of reflux esophagitis, and its effect was compared with RE control and normal rats.ResultsRhei Rhizoma administration markedly ameliorated mucosal damage on histological evaluation. The elevated reactive oxygen species in the esophageal tissue of RE control rats decreased with the administration of Rhei Rhizoma. RE control rats exhibited the down-regulation of antioxidant-related proteins, such as nuclear factor-erythroid 2-related factor 2 (Nrf2) and heme oxygenase-1 (HO-1) expression levels, in the presence of esophagitis; however, the levels with Rhei Rhizoma treatment were significantly higher than those in RE control rats. Moreover, RE control rats exhibited the up-regulation of protein expressions related to oxidative stress in the presence of esophagitis, but Rhei Rhizoma administration significantly reduced the expression of inflammatory proteins through mitogen-activated protein kinase (MAPK)-related signaling pathways. The protein expressions of inflammatory mediators and cytokines by nuclear factor-kappa B (NF-κB) activation were modulated through blocking the phosphorylation of inhibitor of nuclear factor kappa B (IκB)α.ConclusionOur findings support the therapeutic evidence for Rhei Rhizoma ameliorating the development of esophagitis via regulating inflammation through the activation of the antioxidant pathway.Electronic supplementary materialThe online version of this article (doi:10.1186/s12906-015-0974-z) contains supplementary material, which is available to authorized users.

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Reactive oxygen species and chemokines: Are they elevated in the esophageal mucosa of children with gastroesophageal reflux disease?

Abstract: These results suggest that the grade of esophagitis is usually mild or moderate during childhood and factors apart from ROS, IL-8 and MCP-1 may be involved in the pathogenesis of reflux esophagitis in children.

Cited by 3 publications

References 40 publications

Gastro‐oesophageal reflux disease is associated with up‐regulation of desmosomal components in oesophageal mucosa

Gastro‐oesophageal reflux disease is associated with up‐regulation of desmosomal components in oesophageal mucosa

Improvement of Inflammation through Antioxidant Pathway of Gardeniae Fructus 50% EtOH Extract (GE) from Acute Reflux Esophagitis Rats

Protective effect of Rhei Rhizoma on reflux esophagitis in rats via Nrf2-mediated inhibition of NF-κB signaling pathway

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