Gastro‐oesophageal reflux disease is associated with up‐regulation of desmosomal components in oesophageal mucosa

Wex, Thomas; Mönkemüller, Klaus; Stahr, Antje; Kuester, Doerthe; Fry, Lucía C.; Völkel, Simone; Kandulski, Arne; Roessner, Albert; Malfertheiner, Peter

doi:10.1111/j.1365-2559.2011.04123.x

Cited by 16 publications

(18 citation statements)

References 53 publications

(67 reference statements)

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“…Previously, we demonstrated that Pla as the intracellular "desmosomal backbone" and Dsg1, -2, and -3 as "contactforming" members of desmosomes are up-regulated in esophageal mucosa in patients with GERD. This upregulation was considered a repair mechanism that fails to restore the epithelial barrier function completely [25]. Here, we demonstrated a similar induction of desmosomal components in cardia mucosa as well.…”

Section: Discussionmentioning

confidence: 61%

“…The combined presence of both diseases (GERD and H pylori) affected the pattern/degree of inflammation in the cardia mucosa. Previous reports on the same study groups [25,27] demonstrated in these subjects the presence of GERD that was associated with induction of proinflammatory cytokines [27], activation of proteaseactivated receptor 2 [28], and histomorphological alterations in their esophageal mucosa [27].…”

Section: Discussionmentioning

confidence: 99%

“…Demographic and histopathologic data of the study were described in context to the characterization of esophageal mucosa previously [25,27]. In this study, we focused on the cardia mucosa only; therefore, the number of patients differs from previous reports.…”

Section: Patients and Gerd-specific Histomorphological Changesmentioning

confidence: 99%

“…An association between anti-H pylori antibodies and autoimmune bullous disease was recently reported [23]. Clinical studies and animal models have provided evidence that components of desmosomes are up-regulated in relation to GERD [24][25][26].…”

Section: Introductionmentioning

confidence: 99%

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Assessment of desmosomal components (desmoglein 1-3, plakoglobin) in cardia mucosa in relation to gastroesophageal reflux disease and Helicobacter pylori infection

et al. 2012

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Section: Discussionmentioning

confidence: 61%

Section: Discussionmentioning

confidence: 99%

Section: Patients and Gerd-specific Histomorphological Changesmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Assessment of desmosomal components (desmoglein 1-3, plakoglobin) in cardia mucosa in relation to gastroesophageal reflux disease and Helicobacter pylori infection

et al. 2012

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“…1, 2, 3). Desmosomes within the squamous epithelium allow not only the sealing and connecting of cells, but can also provide cellular, protein, or ion transport through intercellular spaces [26]. …”

Section: Second Line Of Defense - the Multilayered Squamous Epitheliummentioning

confidence: 99%

Esophageal Epithelial Resistance

Günther

Neumann²

2014

Dig Dis

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Besides its important role of digestion and absorption, esophageal tissue has an essential role as a major barrier against intraluminal pathogens like hostile microorganisms and toxins. This barrier function is achieved via various mechanical, chemical, and immunological mechanisms which are typically altered in inflammatory diseases, thereby causing subsequent damage of the mucosa. In this review we will focus on the main structural and functional barriers of host defense within the esophageal mucosa, including the epithelial layer, membrane-bound and secretory mucins, and different types of defensins. In addition, we will discuss the relevance of biofilm on esophageal tissue and will illustrate the importance of different regulators of intestinal permeability like zonulin and desmosomal components.

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Abnormal Barrier Function in Gastrointestinal Disorders

Farré

Vicario

2016

Gastrointestinal Pharmacology

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There is increasing concern in identifying the mechanisms underlying the intimate control of the intestinal barrier, as deregulation of its function is strongly associated with digestive (organic and functional) and a number of non-digestive (schizophrenia, diabetes, sepsis, among others) disorders. The intestinal barrier is a complex and effective defensive functional system that operates to limit luminal antigen access to the internal milieu while maintaining nutrient and electrolyte absorption. Intestinal permeability to substances is mainly determined by the physicochemical properties of the barrier, with the epithelium, mucosal immunity, and neural activity playing a major role. In functional gastrointestinal disorders (FGIDs), the absence of structural or biochemical abnormalities that explain chronic symptoms is probably close to its end, as recent research is providing evidence of structural gut alterations, at least in certain subsets, mainly in functional dyspepsia (FD) and irritable bowel syndrome (IBS). These alterations are associated with increased permeability, which seems to reflect mucosal inflammation and neural activation. The participation of each anatomical and functional component of barrier function in homeostasis and intestinal dysfunction is described, with a special focus on FGIDs.

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Gastro‐oesophageal reflux disease is associated with up‐regulation of desmosomal components in oesophageal mucosa

Abstract: Taken together, the uniform up-regulation of desmosomal genes/proteins in the oesophageal mucosa of patients with GERD supports the concept of architectural and molecular changes in the desmosomal compartment in the pathogenesis of GERD.

Cited by 16 publications

References 53 publications

Assessment of desmosomal components (desmoglein 1-3, plakoglobin) in cardia mucosa in relation to gastroesophageal reflux disease and Helicobacter pylori infection

Assessment of desmosomal components (desmoglein 1-3, plakoglobin) in cardia mucosa in relation to gastroesophageal reflux disease and Helicobacter pylori infection

Esophageal Epithelial Resistance

Abnormal Barrier Function in Gastrointestinal Disorders

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