Reactive Nitrogen and Oxygen Species Metabolism in Rat Heart Mitochondria under Administration of Nitric Oxide Donor in Vivo

Indicators of oxidative and nitrosative stress and activity of enzymes of nitric oxide metabolism in rats treated with 4-thiazolidinone derivatives possessing antineoplastic activity

“…3). The inducible NO-synthase and NO-reductase are responsible for the production of nitrogen oxide [4,9], while NO-synthase provides an endo genous synthesis of…”

“…Thus, the nitrate anion can be also considered as a marker of the nitrosative stress [9]. The NOreductase restores the nitrite and nitrate anions to • NO.…”

“…• NO, nitrosothiols, nitrosylation of glutathione, and appearance of the hydrogen sulfide involving SH-groups of cysteine could be important at the action of anticancer agents under study [4,9]. The "reserves" of…”

“…• NO can lead to a nitrosative stress caused by the action of the RNS, especially peroxynitrite and its cleavage product -nitrogen dioxide [4,9]. Application of doxorubicin leads to an increased expression of inducible NO-synthase in the myocardium [4].…”

“…• NO that reacts with superoxide anion radical and peroxynitrite -a powerful pro-oxidant capable of oxidating and nitrosating proteins, lipids and nucleic acids [4,9]. These data demonstrate a significant role of processes related to…”