Indicators of oxidative and nitrosative stress and activity of enzymes of nitric oxide metabolism in rats treated with 4-thiazolidinone derivatives possessing antineoplastic activity

Abstract

Principal ways of generation and function of free oxygen and nitrogen radical metabolites, as well as the ways of their bio-neutralization in rats treated with potential anticancer drugs have been discussed. three isatin-pyrazoline 4-thiazolidinone conjugates -

The level of nitric oxide and arginase activity in patients with arterial hypertension and diabetes mellitus during COVID-19

“…Along with this, in patients with a severe course of COVID-19, an increase in the level of NO is noted [24]. The reason for changes in L-arginine concentration is considered to be fluctuations in the arginase activity, which, together with NO-synthase, competes for a common substrate -L-arginine [25][26][27].…”

“…Although the affinity of NO-synthase for L-arginine is much higher than that of arginase, the affinity of the latter to the L-arginine is a thousand times faster than that of NO-synthase [27,28]. The predominance of the activity of one of these two enzymes determines the function of the vascular endothelium, where NO-synthase maintains the physiological tone of the vessels, while the increase in the activity of arginase contributes to the dysfunction of the vascular endothelium [29,30].…”

“…The patients were receiving inpatient treatment in the therapy center or intensive care in the anesthesiology department of the communal non-commercial enterprise of the First Territorial Medical Association of Lviv. To achieve the set goal, the examinees were divided into three groups: the I group included 30 patients with AH; the II group had 27 Examination of patients and volunteers from the control group was carried out on the basis of generally accepted modern informative research methods, which included clinical (complaints, disea se, life history, palpation, percussion, auscultation); somatometric; laboratory (general blood test, biochemical blood test, lipid profile, PCR to detect SARS-CoV-2 RNA); instrumental studies (echocardiography, if necessary, computed tomography of the lungs and pulse oximetry). The concentration of ferritin, procalcitonin, D-dimer and troponin were determined according to indications.…”