Reactivation of Chagas disease with central nervous system involvement: peripheral blood smear evidence

Verdú, José; Paz, Francisco de; Castaño, Vanessa; Torrús‐Tendero, Diego; Reus, Sergio

doi:10.1016/j.ijid.2009.02.013

Cited by 13 publications

(5 citation statements)

References 3 publications

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“…Accordingly, this would result in missed opportunities for early initiation of specifi c drug therapy in patients with Chagas disease reactivation, which can improve prognosis (15) . In addition, the analysis of medical records revealed no data on meningoencephalic or cardiac involvement in patients, which are clinical and potentially fatal characteristics common in Chagas disease reactivation in HIV-infected patients (7) (8) .…”

Section: Conflict Of Interestmentioning

confidence: 99%

“…T. cruzi behaves opportunistically in individuals with immunosuppression of any etiology, leading to the reactivation of chronic infection with increased parasitemia, worsening of myocarditis, occurrence of meningoencephalitis, and even mortality (7) (8) . Chagas disease reactivation in patients with HIV coinfection has been considered an AIDS-defi ning condition in Brazil since January 2004; moreover, the Brazilian Network of Attention and Studies for T. cruzi/HIV coinfection was established in 2006 (9) (10) .…”

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confidence: 99%

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Serological diagnosis of Chagas disease in HIV-infected patients

Stauffert

Silveira

Mesenburg

et al. 2015

Rev. Soc. Bras. Med. Trop.

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Section: Conflict Of Interestmentioning

confidence: 99%

mentioning

confidence: 99%

Serological diagnosis of Chagas disease in HIV-infected patients

Stauffert

Silveira

Mesenburg

et al. 2015

Rev. Soc. Bras. Med. Trop.

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“…Specifically, the clinical condition refers to the place of the reactivation. Therefore, the neurological condition draws more the attention 25,52,65,66,87 that in most of the times has toxoplasmosis as the main diagnosis in view to the frequency that this condition happens in HIV infected individuals 33,37,68 . In the heart, the symptomatology and the physical aspects overlap those seen on the natural evolution of the chronic chagasic cardiopathy, hindering the diagnosis 22,27,34,42,88 .…”

Section: Casesmentioning

confidence: 99%

Co-infection Trypanosoma cruzi/HIV: systematic review (1980 - 2010)

Almeida

Ramos

Correia

et al. 2011

Rev. Soc. Bras. Med. Trop.

114

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Introduction:The co-infection Trypanosoma cruzi/HIV has been described as a clinical event of great relevance. The objective of this study was to describe clinical and epidemiological aspects published in literature. Methods: It is a systematic review of a descriptive nature from the databases Medline, Lilacs, SciELO, Scopus, from 1980 to 2010. Results: There were 83 articles (2.8 articles/year) with a total of 291 cases. The co-infection was described in 1980 and this situation has become the defining AIDS clinical event in Brazil. This is the country with the highest number of publication (51.8%) followed by Argentina (27.7%). The majority of cases are amongst adult men (65.3%) native or from endemic regions with serological diagnosis in the chronic stage (97.9%) and indeterminate form (50.8%). Both diseases follow the normal course, but in 41% the reactivation of the Chagas disease occurs. The most severe form is the meningoencephalitis, with 100% of mortality without specific and early treatment of the T. cruzi. The medication of choice was the benznidazole on doses and duration normally used for the acute phase. The high parasitemia detected by direct or indirect quantitative methods indicated reactivation and its elevation is the most important predictive factor. The lower survival rate was related to the reactivation of the Chagas disease and the natural complications of both diseases. The role of the antiretroviral treatment on the co-infection cannot yet be defined by the knowledge currently existent. Conclusions: Despite the relevance of this clinical event there are still gaps to be filled.

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“…In HIV-positive patients, the most relevant clinical manifestations of Chagas disease result from reactivation of a chronic T. cruzi infection [30]. The central nervous system is the most commonly affected site, in approximately 75% of cases, with clinical signs of acute meningoencephalitis or space-occupying lesions, rapid clinical progression and a high fatality rate of 79% [30,31] The heart is the second most commonly affected organ (25% to 44% of cases) [31,32]. Peripheral blood parasitaemia, and also cerebrospinal fluid invasion, are very common in those subjects [32].…”

Section: Chagas Disease and Hiv Infectionmentioning

confidence: 99%

Chagas disease in Italy: breaking an epidemiological silence

et al. 2011

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Chagas disease, a neglected tropical disease that due to population movements is no longer limited to Latin America, threatens a wide spectrum of people (travellers, migrants, blood or organ recipients, newborns, adoptees) also in non-endemic countries where it is generally underdiagnosed. In Italy, the available epidemiological data about Chagas disease have been very limited up to now, although the country is second in Europe only to Spain in the number of residents from Latin American. Among 867 at-risk subjects screened between 1998 and 2010, the Centre for Tropical Diseases in Negrar (Verona) and the Infectious and Tropical Diseases Unit, University of Florence found 4.2% patients with positive serology for Chagas disease (83.4% of them migrants, 13.8% adoptees). No cases of Chagas disease were identified in blood donors or HIV-positive patients of Latin American origin. Among 214 Latin American pregnant women, three were infected (resulting in abortion in one case). In 2005 a case of acute Chagas disease was recorded in an Italian traveller. Based on our observations, we believe that a wider assessment of the epidemiological situation is urgently required in our country and public health measures preventing transmission and improving access to diagnosis and treatment should be implemented.

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Reactivation of Chagas disease with central nervous system involvement: peripheral blood smear evidence

Cited by 13 publications

References 3 publications

Serological diagnosis of Chagas disease in HIV-infected patients

Serological diagnosis of Chagas disease in HIV-infected patients

Co-infection Trypanosoma cruzi/HIV: systematic review (1980 - 2010)

Chagas disease in Italy: breaking an epidemiological silence

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