Serological diagnosis of Chagas disease in HIV-infected patients

Stauffert, Dulce; Silveira, Mariângela Freitas da; Mesenburg, Marília Arndt; Gaspar, Thiago; Manta, Adriane Brod; Bicca, Guilherme Lucas de Oliveira; Villela, Marcos Marreiro

doi:10.1590/0037-8682-0268-2014

Cited by 5 publications

(5 citation statements)

References 9 publications

(10 reference statements)

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“…The index of patients serologically positive for T. cruzi found in the present study was low when compared to those found by other studies carried out in this region (Rosenthal et al, 2016;Stauffert et al, 2015); nonetheless, it pointed towards a positive reaction in the Cardiology Outpatient Clinic of the Federal University of Pelotas for anti-T. cruzi antibodies.…”

Section: Discussioncontrasting

confidence: 94%

“…The municipality of Pelotas in southern Rio Grande do Sul is one of these areas where CD prevailed in the past, attaining rates of 0.41% to 4% of positive individuals among blood donors (Baruffa and Alcântara Filho, 1985). Furthermore, recent studies on different groups, such as cancer patients (Rosenthal et al, 2016) and individuals coinfected with HIV (Stauffert et al, 2015), revealed a 5% anti-T. cruzi antibody prevalence rate, 3.8 times as high as Ministry of Health estimates (Brasil, 1998).…”

Section: Introductionmentioning

confidence: 94%

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Seroprevalence of Chagas disease in Southern Brazilian cardiac patients and their knowledge about the parasitosis and vectors

et al. 2021

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Chagas disease (CD) is considered a typical low-income population sickness of the developing countries in Latin America. Given the historical relevance of CD in individuals in southern Rio Grande do Sul (RS) State, Brazil, the aim of this study was to identify the knowledge of the CD and its vectors by cardiac patients, and the prevalence of anti-T cruzi antibodies in these individuals in Pelotas, city located in Rio Grande do Sul (RS) state, Brazil. The subjects with cardiac disease were submitted to a semi-structured questionnaire as well as two serological tests in order to detect anti-T. cruzi IgG antibodies. Of the individuals that born in municipalities showing the highest triatomine infestation rates in recent decades, 81.8% were able to recognize the vector insect (p = 0.0042; OR = 5.9), and 83.3% reported either themselves or someone in their families to have CD (p = 0.043, OR = 5.2). Of the 54 patients submitted to serological analysis, only 01 patient (1.9%) was positive for anti-T. cruzi antibodies, a 55 year old man from the rural area of Canguçu county. This study provides support for the evaluation to be extended to other cardiology centers, given the importance of Chagas disease in Brazil.

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Section: Discussioncontrasting

confidence: 94%

Section: Introductionmentioning

confidence: 94%

Seroprevalence of Chagas disease in Southern Brazilian cardiac patients and their knowledge about the parasitosis and vectors

et al. 2021

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“…Among municipalities with more than 100,000 inhabitants, the city of Pelotas occupies the twentieth position, with 5943 cases. 9 In the same municipality, a study of 252 HIV + patients 13 measured the serologic testing index for Chagas, finding a 3.2% rate (eight patients), seven of whom were negative for trypanosomiasis and one had no results available in his medical record. The authors expressed concern on the low serologic testing index for CD in HIV + patients, since the study was conducted in an area considered to be endemic for the presence of T. cruzi and its vectors.…”

mentioning

confidence: 99%

“…Serological tests for Chagas disease in southern Brazil were requested at the first medical appointment for only 3.2% of HIV cases, even though the 2013 Consensus Document of the Ministry of Health recommends that such tests be requested for all HIV patients at the first appointment. 11 , 13 …”

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confidence: 99%

Prevalence of Trypanosoma cruzi/HIV coinfection in southern Brazil

Stauffert

Silveira

Mesenburg

et al. 2017

The Brazilian Journal of Infectious Diseases

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Chagas disease reactivation has been a defining condition for acquired immune deficiency syndrome in Brazil for individuals coinfected with Trypanosoma cruzi and HIV since 2004. Although the first coinfection case was reported in the 1980s, its prevalence has not been firmly established. In order to know coinfection prevalence, a cross-sectional study of 200 HIV patients was performed between January and July 2013 in the city of Pelotas, in southern Rio Grande do Sul, an endemic area for Chagas disease. Ten subjects were found positive for T. cruzi infection by chemiluminescence microparticle immunoassay and indirect immunofluorescence. The survey showed 5% coinfection prevalence among HIV patients (95% CI: 2.0-8.0), which was 3.8 times as high as that estimated by the Ministry of Health of Brazil. Six individuals had a viral load higher than 100,000copies per μL, a statistically significant difference for T. cruzi presence. These findings highlight the importance of screening HIV patients from Chagas disease endemic areas.

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“…Similarly, US and Spanish HIV guidelines recommend that all PWH with Chagas disease risk factors be screened [ 13 , 54 , 55 ]. Despite this, only a minority of at-risk PWH are screened appropriately [ 56 ].…”

Section: Screening and Diagnosismentioning

confidence: 99%

Chagas Disease in People with HIV: A Narrative Review

Clark

Bern

2021

TropicalMed

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Many questions remain unanswered regarding the epidemiology, pathophysiology, diagnosis, treatment, and monitoring of Trypanosoma cruzi infection in people with HIV (PWH). The reported prevalence of T. cruzi infection in PWH living in endemic countries ranges from 1–28% and is likely similar in at-risk US populations. While classic cardiac and gastrointestinal presentations of chronic Chagas disease occur in PWH, PWH are additionally at risk for a severe and often fatal form of T. cruzi-mediated disease called reactivation disease. T. cruzi reactivation typically occurs in PWH with low CD4 counts and poor virologic control. National HIV guidelines in several endemic South American countries recommend that all PWH be screened for T. cruzi infection at the time of HIV diagnosis; however, this recommendation is not widely implemented. The early detection of T. cruzi infection in PWH is critical as the sequelae of Chagas disease, including T. cruzi reactivation, may be preventable through the restoration of robust cellular immunity via the initiation of antiretroviral therapy and the appropriate use of antitrypanosomal therapy.

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Serological diagnosis of Chagas disease in HIV-infected patients

Cited by 5 publications

References 9 publications

Seroprevalence of Chagas disease in Southern Brazilian cardiac patients and their knowledge about the parasitosis and vectors

Seroprevalence of Chagas disease in Southern Brazilian cardiac patients and their knowledge about the parasitosis and vectors

Prevalence of Trypanosoma cruzi/HIV coinfection in southern Brazil

Chagas Disease in People with HIV: A Narrative Review

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