Re: “Active and Passive Smoking and Risk of Nasopharyngeal Carcinoma: A Population-Based Case-Control Study in Southern China”

Zou, Juntong; Wan, Yao; Zhuang, Zhenxiao; Wan, Han; Liu, Qiuyun

doi:10.1093/aje/kwx351

Cited by 9 publications

(9 citation statements)

References 4 publications

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“…Interestingly, the humid south coastal China and Southeast Asia are high in nasopharyngeal carcinoma prevalence, contrasting with the low rates seen in non-humid regions such as non-coastal areas, a sign of hydrogen bonding generated from amino acid residues of proteins with enhanced expression at high humidity. 19,20 Individuals with diarrhea are much more prone to develop malignancies than normal persons. 21,22 Oncoproteins and tumor suppressors usually possess 10% to over 20% basic amino acids, and turn oncogenic when DNA or amino acid polymorphisms are present.…”

Section: Dietary Regimens To Counteract Strong Acidsmentioning

confidence: 99%

Mutagenesis by RNA-containing telomerase holoenzyme complex or R-loops: a missing piece of the puzzle

Zhang¹,

Lin²,

Wang³

et al. 2022

Preprint

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Overexpression of telomerase has been demonstrated to substantially extend the lifespan of mice. However, this treatment has a negative side, namely the increase of cancer risk. Most components of the telomerase holoenzyme complex possess high basic amino acid content, potentially attracting anions and enhancing the formation of mutagenic and carcinogenic HCl. Weak organic acids antagonize strong acids, and thus can raise cellular pH and modify the microenvironment. R-loops are hybrid DNA and RNA structures, and trigger DNA replication stress and genome instability. RNA has one additional hydroxyl oxygen atom on ribose compared with DNA, and single stranded DNA harbors bases free of hydrogen bonding. These two factors can enhance the buildup of protons via hydrogen bonding and the local formation of HCl. Strong acids generated can augment DNA mutagenesis, and enhance DNA excision, repair and formation of double stranded breaks. Neoplasm must be addressed before lifespan extension remedies via telomerase are ready for use.

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Section: Dietary Regimens To Counteract Strong Acidsmentioning

confidence: 99%

Mutagenesis by RNA-containing telomerase holoenzyme complex or R-loops: a missing piece of the puzzle

Zhang¹,

Lin²,

Wang³

et al. 2022

Preprint

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“…Local buildup of hydrochloric acid (HCl) was proposed as one of the primary causative factors of most cancers. 5,6 The inhabitants of the humid south coastal regions of China and Southeast Asia are at high risk of nasopharyngeal carcinoma, whereas those of non-coastal southern Yunnan Province in China have low nasopharyngeal cancer rates, 7 suggesting that hydrogen bonding is involved in the carcinogenesis of the nasal cavity. 8 It was recently postulated that weak acid counteracts strong acid such as HCl to reduce cancer risks.…”

mentioning

confidence: 99%

The Role of Acetate in the Antagonization of Oxalate: A Potential Causative Molecule for Heart Disease and Cancer Death

Tang

et al. 2020

Natural Product Communications

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Previous reports demonstrated the anticancer effects and the protective effects on cardiovascular diseases of vinegar products. The molecular mechanism underlying these phenomena is not well elucidated. It was proposed that carcinogenesis is triggered by the formation of local strong acids such as HCl. Cancer cells may overproduce weak or moderate organic acids such as oxalate to antagonize strong acids, and calcium oxalate may cause organ failure and death. This study aimed at elucidating the underlying mechanism on the antagonism of apoptosis by acetate on oxalate. Quantitation of cell apoptosis of HEK293T cells in the presence of sodium oxalate and compounds with similar structures to oxalate was conducted by using Annexin V-fluorescein isothiocyanate/propidium iodide staining via flow cytometry. The data indicate that acetate could attenuate the proapoptotic functions of oxalate. This study yields insight into the anticancer and antidisease functions of vinegar products and opens up a new path in the use of weak acetic acid in the prevention and treatment of cancer.

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“…2 Nasopharyngeal carcinoma is prevalent in hot and humid areas such as south coastal China and Southeast Asia, but not in non-coastal southern Yunnan Province in China. 3 The high humidity may induce expression of proteins with extensive hydrogen bonding in the inhabitants of these regions, attracting water and protons and enhancing the formation of HCl. The overconsumption of NaCl increases gastric cancer incidences.…”

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confidence: 99%

Cellular States and Secondary Chemical Bonding: A Biochemical View of Major Human Diseases

Wan

Zhang

et al. 2019

Biochem Insights

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Nasopharyngeal carcinoma is prevalent in hot and humid areas such as south coastal China and Southeast Asia, but not in the non-coastal southern Chinese Yunnan Province. Secondary chemical bonding may underlie such phenomena. Cancer may be caused by strong acids such as HCl, whereas insoluble and rigid salts such as calcium oxalate are the potential causative factors of heart disease and the Alzheimer disease. The weak organic acids produced by plants counteract strong acids and dissolve insoluble salts, therefore boasting dual roles in disease prevention and treatments. The aforementioned perspective sheds light on the underlying mechanism of human disorders and opens new avenues in the interventions of numerous diseases.

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Re: “Active and Passive Smoking and Risk of Nasopharyngeal Carcinoma: A Population-Based Case-Control Study in Southern China”

Cited by 9 publications

References 4 publications

Mutagenesis by RNA-containing telomerase holoenzyme complex or R-loops: a missing piece of the puzzle

Mutagenesis by RNA-containing telomerase holoenzyme complex or R-loops: a missing piece of the puzzle

The Role of Acetate in the Antagonization of Oxalate: A Potential Causative Molecule for Heart Disease and Cancer Death

Cellular States and Secondary Chemical Bonding: A Biochemical View of Major Human Diseases

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