Cellular States and Secondary Chemical Bonding: A Biochemical View of Major Human Diseases

Abstract

Nasopharyngeal carcinoma is prevalent in hot and humid areas such as south coastal China and Southeast Asia, but not in the non-coastal southern Chinese Yunnan Province. Secondary chemical bonding may underlie such phenomena. Cancer may be caused by strong acids such as HCl, whereas insoluble and rigid salts such as calcium oxalate are the potential causative factors of heart disease and the Alzheimer disease. The weak organic acids produced by plants counteract strong acids and dissolve insoluble salts, therefore boasting dual roles in disease prevention and treatments. The aforementioned perspective sheds light on the underlying mechanism of human disorders and opens new avenues in the interventions of numerous diseases.

The Pneumonia Outbreak: High Isoleucine and High Valine Plus Glycine Contents Are Features of the Proteins of COVID-19 Virus

“…The human transmissibility and the long latency period of the Wuhan strains may drive the spread of the virus to other regions of world, underscoring the urgency for preventive measures. As the percentage of essential amino acids in the small orf of COVID-19 reaches 57.4%, a starch/vitamin diet served to the potentially exposed human subpopulation for short period of time does not give rise to essential amino acids such as isoleucine and lysine and reduces the viral load, which could be adopted as prophylactic approach of COVID-19 (Gan et al, 2018;Wan et al, 2019;He et al, 2018;Wahl et al, 2018). Peptides consisting of essential amino acids are often stressful (Tang et al, 2017).…”

“…Valine and glycine content of the orfs of COVID-19 and SARS-CoV are shown in Table 2 and Table 3. Since valine and glycine harbor affinity to divalent cations such as calcium, and isoleucine possesses proton affinity (Qi et al, 2018;Wan et al, 2019;Xing et al, 2017;Wang et al, 2017), valine or glycine compete with isoleucine and alleviate fever and other symptoms. However, high content of valine or/and glycine are implicated in heart disease and other disorders by the formation of insoluble and rigid calcium oxalate which are stressful to the body (Qi et al, 2018;Wan et al, 2019), which accounts for the higher mortality rates in these patients concomitant with COVID-19 infections.…”

“…Lung stickiness could be the cause of respiratory difficulties (Figure 1). (Gu et al, 1994;Wan et al, 2019) The divalency of the calcium ion also enhances viscosity. For instance, hydrogen bonding is critical for the stickiness of boiled starch, whereas ionic and secondary chemical bonding between amino acids and calcium is adopted to make Tofu.…”

The Wuhan Pneumonia Outbreak: High Isoleucine and High Valine Plus Glycine Contents Are Features of the Proteins of 2019-nCoV Virus

“…The human transmissibility and the long latency period of the Wuhan strains may drive the spread of the virus to other regions of world, underscoring the urgency for preventive measures. As the percentage of essential amino acids in the small orf of 2019-nCoV reaches 57.4%, a starch/vitamin diet served to the potentially exposed human subpopulation for short period of time does not give rise to essential amino acids such as isoleucine and lysine and reduces the viral load, which could be adopted as prophylactic approach of 2019-nCoV (Gan et al, 2018;Wan et al, 2019;He et al, 2018;Wahl et al, 2018). Peptides consisting of essential amino acids are often stressful (Tang et al, 2017).…”

“…Valine and glycine content of the orfs of 2019-nCoV is shown in Table 2. Since valine and glycine harbor affinity to divalent cations such as calcium, and isoleucine possesses proton affinity (Qi et al, 2018;Wan et al, 2019;Xing et al, 2017;Wang et al, 2017), valine or glycine compete with isoleucine and alleviate fever and other symptoms. However, high content of valine or/and glycine are implicated in heart disease and other disorders by the formation of insoluble and rigid calcium oxalate which are stressful to the body (Qi et al, 2018;Wan et al, 2019), which accounts for the higher mortality rates in these patients concomitant with 2019-nCoV infections.…”