The Role of Acetate in the Antagonization of Oxalate: A Potential Causative Molecule for Heart Disease and Cancer Death

Abstract

Previous reports demonstrated the anticancer effects and the protective effects on cardiovascular diseases of vinegar products. The molecular mechanism underlying these phenomena is not well elucidated. It was proposed that carcinogenesis is triggered by the formation of local strong acids such as HCl. Cancer cells may overproduce weak or moderate organic acids such as oxalate to antagonize strong acids, and calcium oxalate may cause organ failure and death. This study aimed at elucidating the underlying mechanism on the antagonism of apoptosis by acetate on oxalate. Quantitation of cell apoptosis of HEK293T cells in the presence of sodium oxalate and compounds with similar structures to oxalate was conducted by using Annexin V-fluorescein isothiocyanate/propidium iodide staining via flow cytometry. The data indicate that acetate could attenuate the proapoptotic functions of oxalate. This study yields insight into the anticancer and antidisease functions of vinegar products and opens up a new path in the use of weak acetic acid in the prevention and treatment of cancer.

Is It Possible to Establish a Tumor-Suppressive Microenvironment With Glycine and Valine Supplement?

“…12,13 The coexistence of hydrogen bond donors and acceptors and basic amino acids can gather anions and cations, and build up strong acids such as HCl locally. 12,13 Interestingly, oncoproteins and tumor suppressors usually possess over 10% to over 20% basic amino acids, attract strong anion Cl À , enhance the local formation of HCl, and promote tumor growth when additional amino acid polymorphism is present.…”

“…Alzheimer’s disease and cancer are mutually protective, since insoluble salts and strong acids such as HCl counteract each other chemically, 11 and HCl was postulated as a major inducer of tumorigenesis. 12 , 13 The coexistence of hydrogen bond donors and acceptors and basic amino acids can gather anions and cations, and build up strong acids such as HCl locally. 12 , 13 Interestingly, oncoproteins and tumor suppressors usually possess over 10% to over 20% basic amino acids, attract strong anion Cl − , enhance the local formation of HCl, and promote tumor growth when additional amino acid polymorphism is present.…”

The Pneumonia Outbreak: High Isoleucine and High Valine Plus Glycine Contents Are Features of the Proteins of COVID-19 Virus

“…Due to the presence of insoluble calcium oxalate, cancer patients and young people with constipation problems should be very cautious about the SARS-CoV-2 virus. (Yan et al, 2020;An et al, 2020a;Wan et al, 2019) Individuals with regular diarrhea might develop less severe symptoms as hydrogen bonding capacity allows the buildup of proton pool and acids, which are capable of solubilizing insoluble and rigid salts.…”

The Pneumonia Outbreak: High Isoleucine and High Valine Plus Glycine Contents Are Features of the Proteins of COVID-19 Virus

“…Due to the presence of insoluble calcium oxalate, cancer patients and young people with constipation problems should be very cautious about the COVID-19 virus. (An et al, 2020;Wan et al, 2019) Individuals with regular diarrhea might develop less severe symptoms as hydrogen bonding capacity allows the buildup of proton pool and acids, which are capable of solubilizing insoluble and rigid salts.…”