“…By contrast, it is difficult to co-encapsulate combination drugs in the manner of controllable ratios for the conventional remote loading driven by an ion gradient, which was probably due to different molecular interactions between ions and drugs. [23][24][25] The drug retention in liposomes was investigated by incubating them in the rat plasma at 38 1C, and the drug release from the liposome was measured by HPLC. It is shown that MAL-ferried drug-loaded liposomes generally exhibited a sustained drug release (20-78%, within 48 h, Fig.…”
mentioning
confidence: 99%
“…By contrast, it is difficult to co-encapsulate combination drugs in the manner of controllable ratios for the conventional remote loading driven by an ion gradient, which was probably due to different molecular interactions between ions and drugs. 23–25…”
The development of liposome-based drugs was severely limited due to inefficient loading strategies. Herein, we developed a click reaction-mediated loading procedure by designing an enzyme-sensitive maleimide (MAL) tag for ferrying...
“…By contrast, it is difficult to co-encapsulate combination drugs in the manner of controllable ratios for the conventional remote loading driven by an ion gradient, which was probably due to different molecular interactions between ions and drugs. [23][24][25] The drug retention in liposomes was investigated by incubating them in the rat plasma at 38 1C, and the drug release from the liposome was measured by HPLC. It is shown that MAL-ferried drug-loaded liposomes generally exhibited a sustained drug release (20-78%, within 48 h, Fig.…”
mentioning
confidence: 99%
“…By contrast, it is difficult to co-encapsulate combination drugs in the manner of controllable ratios for the conventional remote loading driven by an ion gradient, which was probably due to different molecular interactions between ions and drugs. 23–25…”
The development of liposome-based drugs was severely limited due to inefficient loading strategies. Herein, we developed a click reaction-mediated loading procedure by designing an enzyme-sensitive maleimide (MAL) tag for ferrying...
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