Rapid turbidimetric assay to potency evaluation of tigecycline in lyophilized powder

Silva, Lucélia Magalhães da; Salgado, Hérida Regina Nunes

doi:10.1016/j.mimet.2015.01.017

Cited by 24 publications

(13 citation statements)

References 27 publications

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“…Although the turbidimetric assay is not suitable to determine this kind of impurity and the degradation products, it is an environmentally-friendly method, which does not require the use of organic solvents for its analysis, which is in line with the global trend. Furthermore, it is a method increasingly used and recognized for the analysis of antimicrobial agents [ 37 , 46 , 47 , 48 , 49 , 50 ].…”

Section: Resultsmentioning

confidence: 99%

Rapid Turbidimetric Assay to Determine the Potency of Daptomycin in Lyophilized Powder

Tótoli

Salgado

2015

Pharmaceutics

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Daptomycin is an important antimicrobial for clinical practice, mainly because it remains very active against Gram-positive resistant strains, such as methicillin-resistant Staphylococcus aureus and vancomycin-resistant enterococci. Development of microbiological methods for the analysis of antimicrobials is highly recommended, since they can provide important information about their biological activities, which physicochemical methods are not able to provide. Considering that there are no studies in the literature describing microbiological methods for the analysis of daptomycin, the aim of this work was to validate a microbiological method for the quantitation of daptomycin by the turbidimetric assay. Staphylococcus aureus was used as the test microorganism, and the brain heart infusion broth was used as the culture medium. The validation of the method was performed according to the ICH guidelines, and it was shown to be linear, precise, robust, accurate and selective, over a concentration range of 8.0 to 18.0 µg mL−1. Student’s t-test showed the interchangeability of the proposed method with a previously-validated HPLC method. The developed turbidimetric method described in this paper is a convenient alternative for the routine quality control of daptomycin in its pharmaceutical dosage form.

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Section: Resultsmentioning

confidence: 99%

Rapid Turbidimetric Assay to Determine the Potency of Daptomycin in Lyophilized Powder

Tótoli

Salgado

2015

Pharmaceutics

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“…Some examples of drugs ( Figure 3) with turbidimetric method described in the literature are doxycycline [23], ampicillin [24], ciprofloxacin [25], cefuroxime [26], cefazolin [27], tigecycline [28] and daptomycin [29].…”

Section: Turbidimetric Methodsmentioning

confidence: 99%

Analytical Methods Need Optimization to Get Innovative and Continuous Processes for Future Pharmaceuticals

Kogawa¹,

Carolina²,

Salgado³

et al. 2016

SAJP

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Abstract:The quality of a pharmaceutical product is directly related to the health of patients. This consideration is evidenced by the results of studies of various researchers, which show that a practical and precise method of analysis can be the first step in the rational use of medicines. Most of the time, drugs and medicines even with all its importance and all its uses lack analytical methods in the literature and in most official compendia for their Quality Control. During the development of a new analytical method, as liquid chromatography, must be considered various factors, such as reliability, detection and separation of all compounds of interest, speed analysis to optimize equipment and analysts, reduced need for pretreatment of the sample, low final cost analysis when the reagents, procedures and machinery are accounted, and use of non-toxic reagents neither for the operator or for the environment, that is, environmentally friendly methods. Using techniques, green methods considered, as infrared spectrophotometric and turbidimetric methods make remediation of environmental impacts frequently observed nowadays unnecessary. The use of simple and easy methods of execution, fast, precise, accurate and environmentally friendly becomes more and more interesting for the pharmaceutical industry in Quality Control of drugs and medicines. The lack of environmental friendly methods for the analysis of pharmaceuticals with minimum generation of toxic waste and the consciousness of the analytical decisions is a gap that currently drives the research groups.

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“…In the literature there are many physical-chemical and microbiological methods for the evaluation of drugs and pharmaceuticals which contemplate green analytical chemistry items such as HPLC methods using only ethanol and water in the mobile phase (Tótoli and Salgado, 2014, Pedroso et al, 2016, Spagnol et al, 2016, Rodrigues and Salgado, 2016, Figueiredo et al, 2017, Kogawa et al, 2017, Marco and Salgado, 2017), spectrophotometry in the ultraviolet region (UV) using aqueous solution as diluent (Kogawa and Salgado, 2013, Alessio et al, 2017, Kogawa and Salgado, 2016), spectrophotometry in the visible region (Vis) using aqueous solution as diluent (Brbaklic et al, 2017, Rechelo et al, 2017), spectrophotometry in the infrared region (IR) using only potassium bromide as reagent (Moreno and Salgado, 2012, Tótoli and Salgado, 2012, Vieira et al, 2012, Kogawa and Salgado, 2013, Piantavini et al, 2014, Mallah et al, 2015, Marco and Salgado, 2016, Trindade and Salgado, 2017), capillary electrophoresis (CE) with migration time less than 5 min (Kogawa et al, 2014, Tótoli et al, 2015, Chierentin et al, 2016) and microbiological methods with results in 4 h (Kogawa et al, 2012, Tótoli and Salgado, 2013, Cazedey and Salgado, 2013, Vieira et al, 2014, Pedroso and Salgado, 2014, Chierentin and Salgado, 2015, Silva and Salgado, 2015, Tótoli and Salgado, 2015, Curbete and Salgado, 2016, Kogawa and Salgado, 2016).…”

Section: Impacts Of Green Chemistrymentioning

confidence: 99%

“…A time-consuming method that releases results within 24 h or more, such as microbiological results for antibiotics, will make products expensive or, if released without this analysis, perhaps inefficient which can promote the overload of the health system and contribute to microbial resistance (Kogawa et al, 2012, Tótoli and Salgado, 2013, Cazedey and Salgado, 2013, Vieira et al, 2014, Pedroso and Salgado, 2014, Chierentin and Salgado, 2015, Silva and Salgado, 2015, Tótoli and Salgado, 2015, Curbete and Salgado, 2016, Kogawa and Salgado, 2016).…”

Section: Impacts Of Green Chemistrymentioning

confidence: 99%

Evolution of green chemistry and its multidimensional impacts: A review

Marco

Rechelo

Tótoli

et al. 2019

Saudi Pharmaceutical Journal

Self Cite

282

129

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The growing process of industrialization was a milestone for world economic evolution. Since the 1940s, social movements have revolutionized green chemistry and provided shifts in industrial positions and sustainable processes with advances in environmental impact and awareness of companies and population. Paul Anastas and John Warner, in the 1990s, postulated the 12 principles of Green Chemistry, which are based on the minimization or non-use of toxic solvents in chemical processes and analyzes, as well as, the non-generation of residues from these processes. One of the most active areas of Research and Development in Green Chemistry is the development of analytical methodologies, giving rise to the so-called Green Analytical Chemistry. The impacts of green chemistry on pharmaceutical analyzes, environmental, population, analyst and company are described in this review and they are multidimensional. Every choice and analytical attitude has consequences both in the final product and in everything that surrounds it. The future of green chemistry as well as our future and the environment is also contemplated in this work.

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Rapid turbidimetric assay to potency evaluation of tigecycline in lyophilized powder

Cited by 24 publications

References 27 publications

Rapid Turbidimetric Assay to Determine the Potency of Daptomycin in Lyophilized Powder

Rapid Turbidimetric Assay to Determine the Potency of Daptomycin in Lyophilized Powder

Analytical Methods Need Optimization to Get Innovative and Continuous Processes for Future Pharmaceuticals

Evolution of green chemistry and its multidimensional impacts: A review

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