Rapid, Routine Method for the Analysis of Some Drugs with Bromate and Celestine Blue

Sastry, C. S. P.; Rao, S.Gopala; Naidu, P. Y.; Srinivas, K

doi:10.1080/00032719808002044

Cited by 28 publications

(7 citation statements)

References 8 publications

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“…The methods reported by Ashry and Ibrahim [38] either lack sensitivity (using Nbromophthalimide-promethazine) or involves boiling for 30 min (using molybdophosphoric acid), and hence unsuitable for routine analysis. A few indirect spectrophotometric methods involving the use of bromate-celestine blue [39], 2,2 -diphenyl-1-picryl hydrazyl [40], chromium(VI)-metol-primary arylamine [41], iron(III)-1,10-phenanthroline [42] and metavanadate-H 2 O 2 [43] combinations are also found in literature, but suffer from one or the other disadvantage.…”

Section: Introductionmentioning

confidence: 99%

Argentimetric assay of captopril in bulk drug and in tablets

Basavaiah

Nagegowda

2004

JICS

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Three simple, selective and cost-effective procedures for the determination of captopril in bulk drug and in tablets are described. All the procedures make use of silver nitrate as a reagent and involve titrimetry and spectrophotometry as measurement techniques. In titrimetry (Method A), the aqueous solution of the drug is titrated directly with the standard silver nitrate solution to a potassium chromate end-point. In one spectrophotometric method (Method B), the sample solution is treated with excess of silver nitrate and a known amount of methyl orange and the increase in absorbance at 520 nm, caused by a decrease in pH due to release of nitric acid, is measured and related to drug concentration. The other spectrophotometric method (Method C) involves the addition of a measured excess of silver nitrate to the sample solution followed by the determination of residual silver ion by an ion-associate complex formation reaction involving eosin and 1,10-phenanthroline. The decrease in absorbance at 550 nm, which corresponds to Ag + reacted with the drug, is measured and is found to be linearly related to drug concentration. All experimental variables involved in the methods were investigated and optimized. Stoichiometry of the reaction that forms the basis for titrimetry is found. Method A is applicable in the range of 1.0-20.0 mg of drug while methods B and C can be conveniently used in the concentration ranges of 2.5-50.0 and 0.25-4.0 g ml -1 , respectively. Several optical characteristics such as molar absorptivity, Sandell sensitivity, limits of detection and quantification, and correlation coefficient were calculated. The methods were applied to the analysis of tablets containing captopril. Statistical treatment of the results indicates that the procedures are precise and accurate. The excipients used as additives in tablets did not interfere in the proposed procedures as revealed by the recovery studies.

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Section: Introductionmentioning

confidence: 99%

Argentimetric assay of captopril in bulk drug and in tablets

Basavaiah

Nagegowda

2004

JICS

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“…Many dyes are irreversibly destroyed to colorless products by oxidizing agents in acid medium [29] and this observation has been exploited for the indirect spectrophotometric determination of some bioactive compounds [30][31][32][33][34]. The bromination reaction was found to be complete in 15 min and contact time up to 30 min had no effect on the stoichiometry or the results.…”

Section: Methods Developmentmentioning

confidence: 99%

Titrimetric and spectrophotometric determination of doxycycline hyclate using bromate-bromide, methyl orange and indigo carmine

Jagannathamurthy

Basavaiah

Ranganath

et al. 2010

CI&CEQ

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One titrimetric and two indirect spectrophotometric methods are described for the determination of doxycycline hyclate (DCH) in bulk drug and in its formulations. The methods use bromate-bromide, methyl orange and indigo carmine as reagents. In titrimetry (method A), DCH is treated with a known excess of bromate--bromide mixture in acid medium and the residual bromine is back titrated iodometrically after the reaction between DCH and in situ bromine is ensured to be complete. In spectrophotometric methods, the excess of bromine is estimated by treating with a fixed amount of either methyl orange (method B) or indigo carmine (method C) and measuring the change in absorbance either at 520 or 610 nm. Titrimetric method is applicable over 1-8 mg range and the calculations are based on a 1:2 (DCH:bromate) stoichiometric ratio. In spectrophotometry, the calibration graphs were found to be linear over 0.25-1.25 and 1.0-5.0 µg mL -1 for method B and C, respectively, with corresponding molar absorptivity values of 2.62×10 5 and 6.97×10 4 L mol -1 cm -1 . The accuracy and precision of the assays were determined by computing the intra-day and inter-day variations at three different levels of DCH.

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“…Many dyes are irreversibly destroyed to colourless products by oxidizing agents in acid medium 27 and this observation has been exploited for the indirect spectrophotometric determination of some bioactive compounds. [28][29][30][31][32] In recent years, acidified solution of bromate and bromide and dyes have been adapted to the quantification of several pharmaceutical substances. [19][20][21][22][23][24][25] In the proposed spectrophotometric methods, the ability of bromine to cause bromination of AST and irreversibly destroy methyl orange and indigo carmine dyes to colourless products in acid medium has been used.…”

Section: Methods Developmentmentioning

confidence: 99%

Simple and practicable methods for the determination of astemizole in pharmaceuticals using bromate-bromide and two dyes

Nagegowda¹,

Basavaiah²

2005

J. Braz. Chem. Soc.

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Um método titrimétrico e dois espectrofotométricos, simples e sensíveis, são descritos para a determinação de astemizola (AST) em drogas comerciais e formulações. Os métodos usam a mistura brometo-bromato e dois pigmentos, laranja de metila e índigo carmim. Na titrimetria (Método A), astemizola é tratada com uma mistura ácida de brometo-bromato em excesso conhecido e depois do término completo da reação de bromatação, o excesso de bromo é reversamente titulado iodometricamente. Nos métodos espectrofotométricos, o excesso de bromo é estimado após o tratamento com uma quantia determinada de laranja de metila (Método B) ou índigo carmim (Metodo C), e as mudanças de absorbância medidas em 520 e 610 nm, respectivamente. Em todos os métodos, a quantidade de bromato reagido corresponde à quantidade na droga. O método tritrimetrico é aplicável na faixa de 4-16 mg e os cálculos são feitos numa relação 1:0,666 (AST:bromato). Nos espectrofotométricos, a curva de calibração é linear entre 0,5 e 4,0 µg mL (Método B) e entre 1,25 e 12,5 µg mL (Método C), com valores de absortividade molar de 6,6x10, respectivamente. Os limites de detecção e quantificação são apresentados para os Métodos B e C. A avaliação estatística foi examinada pela precisão da determinação intra-e inter-diária. Os métodos são aplicáveis na determinação de AST em cápsulas e xaropes, e os resultados são concordantes com os apresentados em rótulo. A exatidão e confiabilidade dos métodos foram testadas pela determinação paralela por um método de referência, com limite de confiança de 95% para valores t-Student e F-Student, e por estudos de recuperação por adição padrão.One titrimetric and two spectrophotometric methods, which are simple and sensitive, are described for the determination of astemizole (AST) in bulk drug and formulations. The methods use bromatebromide mixture and two dyes, methyl orange and indigo carmine. In titrimetry (Method A), astemizole is treated with a known excess of bromate-bromide mixture in acid medium and after the bromination reaction is ensured to be complete, the residual bromine is back-titrated iodometrically. In spectrophotometric methods, the excess of bromine is estimated by treating it with a fixed amount of either methyl orange (Method B) or indigo carmine (Method C) and measuring the change in absorbance either at 520 or 610 nm. In all the methods, the amount of bromate reacted corresponds to the drug content. Titrimetric method is applicable over 4-16 mg range and the calculations are based on a 1:0.666 (AST: bromate) reacting ratio. In spectrophotometry, the calibration graph is found to be linear over 0.5-4.0 µg mL -1 (Method B) and 1.25 -12.5 µg mL -1 (Method C) with molar absorptivity values of 6.6 x 10 4 L mol -1 cm -1 and 2.1 x 10 4 L mol -1 cm -1, respectively. The limits of detection and quantification are reported for methods B and C. The statistical evaluation of the methods was examined by determining intra-day and inter-day precision. The methods were applied to the determination of AST in tablets and syrup...

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Rapid, Routine Method for the Analysis of Some Drugs with Bromate and Celestine Blue

Cited by 28 publications

References 8 publications

Argentimetric assay of captopril in bulk drug and in tablets

Argentimetric assay of captopril in bulk drug and in tablets

Titrimetric and spectrophotometric determination of doxycycline hyclate using bromate-bromide, methyl orange and indigo carmine

Simple and practicable methods for the determination of astemizole in pharmaceuticals using bromate-bromide and two dyes

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