Rapid quantitative detection of chloramphenicol in milk by microfluidic immunoassay

Zhao, Mantong; Li, Xiaolong; Zhang, Yule; Wang, Yuwen; Wang, Bo; Zheng, Lulu; Zhang, Dawei; Zhuang, Songlin

doi:10.1016/j.foodchem.2020.127857

Cited by 75 publications

(31 citation statements)

References 34 publications

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“…A similar problem can arise in the use of certain animal feeds and environmental medications [ 70 ]. Consequently, the literature contains many microfluidic devices for the detection of antibiotics and drugs, such as ampicillin [ 71 ], β-lactamase [ 72 , 73 ], 17β-estradiol [ 74 ], bacitracin zinc [ 75 ], chloramphenicol [ 76 , 77 ], clarithromycin [ 78 ], clenbuterol [ 79 ], ciprofloxacin [ 80 ], enrofloxacin [ 81 ], monensin [ 82 ], norfloxacin [ 83 ], streptomycin [ 84 ], and tylosin and tilmicosin [ 85 ].…”

Section: Microfluidic Platforms For Milk Sample Analysismentioning

confidence: 99%

Recent Advances in Microfluidic Devices for Contamination Detection and Quality Inspection of Milk

Lee

Kung

et al. 2021

Micromachines

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Milk is a necessity for human life. However, it is susceptible to contamination and adulteration. Microfluidic analysis devices have attracted significant attention for the high-throughput quality inspection and contaminant analysis of milk samples in recent years. This review describes the major proposals presented in the literature for the pretreatment, contaminant detection, and quality inspection of milk samples using microfluidic lab-on-a-chip and lab-on-paper platforms in the past five years. The review focuses on the sample separation, sample extraction, and sample preconcentration/amplification steps of the pretreatment process and the determination of aflatoxins, antibiotics, drugs, melamine, and foodborne pathogens in the detection process. Recent proposals for the general quality inspection of milk samples, including the viscosity and presence of adulteration, are also discussed. The review concludes with a brief perspective on the challenges facing the future development of microfluidic devices for the analysis of milk samples in the coming years.

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Section: Microfluidic Platforms For Milk Sample Analysismentioning

confidence: 99%

Recent Advances in Microfluidic Devices for Contamination Detection and Quality Inspection of Milk

Lee

Kung

et al. 2021

Micromachines

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“…It is also a fact that, being heat resistant, antibiotic agents are not destroyed even when exposed to high temperatures when processing food (Hassan, et al, 2020). So, eating food contaminated with residual antibiotics may cause serious health effects: different allergic responses, insensitivity or super-susceptibility to antibacterial agents, disturbance of intestinal microflora and so on (Zhang, et al, 2010, Zhao, et al, 2021.…”

Section: A R T I C L E I N F Omentioning

confidence: 99%

Assessing the Risk of Antibiotic Residues in Milk Produced in the Republic of Armenia

Pipoyan

Beglaryan

Gharibyan

et al. 2021

AgriScience and Technology

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This research sets out to assess both the antibiotic exposure via milk produced in the Republic of Armenia and the associated human health risks. As established, the milk of domestic production contains residual antibiotics (streptomycin, chloramphenicol, tetracyclines). The estimated daily intake (EDI) and the margin of exposure (MOE) for the antibiotics identified upon this research were assessed. It has been indicated that for the population of Yerevan, the daily intake of antibiotics via milk does not exceed the acceptable daily intake (ADI). Moreover, the derived MOE values point to the absence of health risks associated with shop-bought milk.

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“…The detection of CAP in food becomes an important control strategy to prevent CAP from entering the human body. Now, immunoassay 7 , electrochemical detection assay 8 and high-performance liquid chromatography-tandem mass spectrometry 9 have been widely used in the detection of CAP. They are sensitive and accurate.…”

Section: Introductionmentioning

confidence: 99%

A visual on-site biosensor for low-cost detection of chloramphenicol based on aptamer and split DNAzyme

Chen

et al. 2022

ANAL. SCI.

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Chloramphenicol (CAP) is a kind of broad-spectrum antibiotics, which has been forbidden in food by most countries because of its side effects. In this study, a simple and low-cost biosensor for CAP detection in food was developed. The biosensor only consisted of an aptamer specific to CAP and a pair of split probes that could self-assemble as DNAzyme. The detection result could be identified by the naked eye and the visual limit was 10 nM CAP. The absorbance of final reaction products at 417 nm had a linear relationship with the logarithm of the CAP concentration ranged from 10 to 200 nM, and the limit of detection was 87.3 pM. The visual analysis by imageJ also showed a linear detection range between 25 and 200 nM. The whole detection could be finished in about 1.5 hours with about 0.16 dollars per reaction. We believe that the biosensor shows great potential in the rapid and sensitive detection of CAP in food.

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Rapid quantitative detection of chloramphenicol in milk by microfluidic immunoassay

Cited by 75 publications

References 34 publications

Recent Advances in Microfluidic Devices for Contamination Detection and Quality Inspection of Milk

Recent Advances in Microfluidic Devices for Contamination Detection and Quality Inspection of Milk

Assessing the Risk of Antibiotic Residues in Milk Produced in the Republic of Armenia

A visual on-site biosensor for low-cost detection of chloramphenicol based on aptamer and split DNAzyme

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