Rapid Prototyping of Tissue-Engineering Constructs, Using Photopolymerizable Hydrogels and Stereolithography

Dhariwala, Busaina; Hunt, Elaine; Boland, Thomas

doi:10.1089/1076327042500256

Cited by 92 publications

(104 citation statements)

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“…Over the last decade, development of fabrication technologies for porous scaffolds has been an intensive area of research. Readers are also directed to several excellent review articles for various fabrication technologies [25,34,50,54,107,109,124,125]. In general, these technologies can be classified into (1) processes using porogens in biomaterials, (2) solid free-form or rapid prototyping technologies and (3) techniques using woven or non-woven fibers.…”

Section: Scaffolding Approaches In Tissue Engineeringmentioning

confidence: 99%

“…In the second category, hierarchical porous structures are manufactured by sequential delivery of material and/or energy needed to bond the materials to preset points in space [50]. Some solid free-form fabrication technologies [34,50, 54] such as selective laser sintering, stereolithography and 3D printing depend on precise delivery of light or heat energy in a scanner system to points of space in the material bed so as to bond or crosslink the materials to give solid structures in an otherwise soluble bed of materials. Some solid freeform fabrication technologies [50] such as wax printing rely on simultaneous delivery of solid materials and removable supporting materials in a layer-by-layer printing manner.…”

Section: Scaffolding Approaches In Tissue Engineeringmentioning

confidence: 99%

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Scaffolding in tissue engineering: general approaches and tissue-specific considerations

2008

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Scaffolds represent important components for tissue engineering. However, researchers often encounter an enormous variety of choices when selecting scaffolds for tissue engineering. This paper aims to review the functions of scaffolds and the major scaffolding approaches as important guidelines for selecting scaffolds and discuss the tissue-specific considerations for scaffolding, using intervertebral disc as an example.

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Section: Scaffolding Approaches In Tissue Engineeringmentioning

confidence: 99%

Section: Scaffolding Approaches In Tissue Engineeringmentioning

confidence: 99%

Scaffolding in tissue engineering: general approaches and tissue-specific considerations

2008

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“…[51] Boland and co-workers demonstrated that the commercial laser-based SL apparatus could be adapted to fabricate scaffolds composed of poly(ethylene oxide) and poly(ethylene glycol) dimethacrylate hydrogels. [52] These hydrogels were shown to mimic the mechanical properties of soft tissues in biological systems, and viable encapsulation of cells within these hydrogels was also demonstrated. Wicker and co-workers subsequently used an SL system to fabricate complex 3D cell-laden structures.…”

Section: D Printing Apparatus For Biofabricationmentioning

confidence: 99%

Biomimicry, Biofabrication, and Biohybrid Systems: The Emergence and Evolution of Biological Design

Raman

Bashir

2017

Adv Healthcare Materials

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how the concept of bioinspiration, or imitating biological design and functionality in synthetic materials, created a new class of "smart" biomimetic materials. Then, we shall discuss how the continuing development of enabling manufacturing technologies, such as 3D printing and microfluidics, has established the separate subdiscipline of biofabrication for tissue engineering, or "building with biology." Finally, we shall investigate the convergence of these two fields into the emerging discipline of biohybrid design, the use of biological materials to power non-natural functional behaviors in synthetic machines. Throughout this report, we will revisit a single class of materials, hydrogels, as a case study of biological design in the context of each subfield, and discuss how the constraints, underlying principles, and end-use applications differ in each case. We will also discuss ethical considerations of biological design, with a special focus on forward engineering non-natural or hypernatural functional behaviors in biohybrid systems. We will conclude with recommendations for implementing biological design into educational curricula, ensuring effective and responsible practices for the next generation of engineers and scientists. Biomimicry and Bioinspired DesignA deeper understanding of the underlying design principles that govern biological systems has inspired the field of biomimicry. [1,2] Observing adaptive phenomena in nature, scientists and engineers have sought to extract the components of biological design responsible for this behavior and replicate the behavior in synthetic materials. Fundamentally, this involves understanding the building blocks or base units from which a biological material is built, the hierarchical assembly of these building blocks, and the interactions and interfaces between them.In this section, we will discuss strategies that engineers and scientists have employed to engineer bioinspired hierarchy, from bottom-up self-assembly and top-down engineered assembly. We will present several key demonstrations of stimulus-responsive hydrogels ranging from the micro-to the macroscale, and investigate novel demonstrations in biomimetic actuation and movement. We will conclude with the remaining challenges in the field of biomimicry and discuss the potential future impact of bioinspired design.The discipline of biological design has a relatively short history, but has undergone very rapid expansion and development over that time. This Progress Report outlines the evolution of this field from biomimicry to biofabrication to biohybrid systems' design, showcasing how each subfield incorporates bioinspired dynamic adaptation into engineered systems. Ethical implications of biological design are discussed, with an emphasis on establishing responsible practices for engineering non-natural or hypernatural functional behaviors in biohybrid systems. This report concludes with recommendations for implementing biological design into educational curricula, ensuring effective and responsible practice...

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“…This will allow tissue engineered pulp tissue to be administered in a soft three-dimensional scaffold matrix, such as a polymer hydrogel. Hydrogels are injectable scaffolds that can be delivered by syringe [100,101] . Hydrogels have the potential to be noninvasive and easy to deliver into root canal systems.…”

Section: Naturally Derived Scaffold:-alginate:-mentioning

confidence: 99%

Scaffolds in Regenerative Endodontics: A Review.

Ch¹,

Suvarna²,

Shetty³

et al. 2017

IJAR

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Rapid Prototyping of Tissue-Engineering Constructs, Using Photopolymerizable Hydrogels and Stereolithography

Cited by 92 publications

References 0 publications

Scaffolding in tissue engineering: general approaches and tissue-specific considerations

Scaffolding in tissue engineering: general approaches and tissue-specific considerations

Biomimicry, Biofabrication, and Biohybrid Systems: The Emergence and Evolution of Biological Design

Scaffolds in Regenerative Endodontics: A Review.

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