Rapid prototyping of glass microchannels

Rodriguez, Indalesio; Spicar-Mihalic, Paolo; Kuyper, Christopher L.; Fiorini, Gina S.; Chiu, Daniel T.

doi:10.1016/s0003-2670(03)01000-6

Cited by 94 publications

(61 citation statements)

References 39 publications

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“…Glass is one of the most attractive materials in a wide variety of applications, which include micro-optical element, display, storage device, micro-total analysis system and so on [1][2][3][4], because the glass offers good durability, smoothness, highelectrical isolation and high-optical transparency. In these fields, micro-processing techniques such as fabricating a micro-pattern on the glass surface play an important role in the properties [5][6][7].…”

Section: Introductionmentioning

confidence: 99%

Fabrication of micro-structure on glass surface using micro-indentation and wet etching process

Saito

Okamoto

Miki

et al. 2008

Applied Surface Science

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Section: Introductionmentioning

confidence: 99%

Fabrication of micro-structure on glass surface using micro-indentation and wet etching process

Saito

Okamoto

Miki

et al. 2008

Applied Surface Science

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“…Therefore, glass seems to be an ideal substrate for performing microfluidic immunoassays. However, glassbased microfluidic devices are usually fabricated by a wet etching method, 19 which still limits the etched microstructures to low aspect ratio features. Again, some expensive dry-etching processes for glass can be applied to address this limitation.…”

Section: Glassmentioning

confidence: 99%

Microfluidic Immunoassays

Lin¹,

Wang²,

Wu³

et al. 2010

Journal of the Association for Laboratory Automation

119

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I mmunoassays have long been widely used in a variety of applications, such as for medical diagnostics, pharmaceutical analysis, environmental, food safety testing, and for basic scientific investigations because of its simplicity, sensitivity, and specificity. Microfluidic systems, also well known as a ''lab-on-a-chip'' or a ''micro-total-analysis-system'' have attracted a lot of attention in the past two decades because of advantages associated with miniaturization, integration, and automation. A promising platform for the combination of these two technologies, microfluidic immunoassays, has been extensively explored in recent years. The aim of this article is to review recent advancements in microfluidic immunoassays. A brief introduction to immunoassays and microfluidic devices will include a literature review, followed by an in-depth discussion of essential techniques in designing a microfluidic-based immunoassay from different perspectives, including device substrates, sample/reagent transportation, surface modification, immobilization, and detection schemes. Finally, future perspectives on microfluidic immunoassays will be provided. These developments with microfluidic immunoassays may provide a promising tool for automatic, sensitive, and selective measurements in practical applications.

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“…Despite the many advantages of plastic-based microfluidic systems, they are not appropriate for certain applications, in particular for those that use hydrophobic molecules and organic solvents or require robust and stable surface characteristics [1]. Therefore, glass is the preferred material for such applications.…”

Section: Introductionmentioning

confidence: 99%