2017
DOI: 10.1101/180406
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Abstract: The Oxford Nanopore MinION sequencing platform offers direct analysis of DNA reads as they are generated, which combined with its low cost, low power and extremely compact size, makes the device attractive for in-field or clinical deployment, e.g. rapid diagnostics. We employed the MinION platform for shotgun metagenomic sequencing and analysis of mixed gut-associated microbial communities; firstly, we used a 20 species human microbiota mock community to show that Nanopore metagenomic data can be classified re… Show more

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Cited by 35 publications
(42 citation statements)
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“…For example, a recent study applied metagenomic sequencing directly to prosthetic joint infection samples and demonstrated that this technique can be used to accurately diagnose this type of infection . The application of genomics directly to patient samples is particularly attractive for prosthetic joint infections, as the organisms that cause these infections can be present at very low levels and take 1–2 weeks to grow, whereas genomic pipelines can detect organisms and identify clinically relevant phenotypes within hours . The management of another slow‐growing organism for which resistance is a concern, Mycobacterium tuberculosis , is another clinical situation that might be improved with rapid genomic diagnostics.…”
Section: Clinical Diagnosticsmentioning
confidence: 99%
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“…For example, a recent study applied metagenomic sequencing directly to prosthetic joint infection samples and demonstrated that this technique can be used to accurately diagnose this type of infection . The application of genomics directly to patient samples is particularly attractive for prosthetic joint infections, as the organisms that cause these infections can be present at very low levels and take 1–2 weeks to grow, whereas genomic pipelines can detect organisms and identify clinically relevant phenotypes within hours . The management of another slow‐growing organism for which resistance is a concern, Mycobacterium tuberculosis , is another clinical situation that might be improved with rapid genomic diagnostics.…”
Section: Clinical Diagnosticsmentioning
confidence: 99%
“…Further illustrating the potential for rapid turnaround, Leggett et al . recently demonstrated real‐time organism and resistance profile identification from the feces of an ill infant that took less than 1 hour …”
Section: Clinical Diagnosticsmentioning
confidence: 99%
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