2018
DOI: 10.1111/nyas.13672
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Genomic epidemiology of multidrug‐resistant Gram‐negative organisms

Abstract: The emergence and spread of antibiotic-resistant Gram-negative bacteria (rGNB) across global healthcare networks presents a significant threat to public health. As the number of effective antibiotics available to treat these resistant organisms dwindles, it is essential that we devise more effective strategies for controlling their proliferation. Recently, whole-genome sequencing has emerged as a disruptive technology that has transformed our understanding of the evolution and epidemiology of diverse rGNB spec… Show more

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Cited by 17 publications
(12 citation statements)
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References 178 publications
(423 reference statements)
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“…The rate of discovery and development of new and effective antibiotics has slowed considerably (Norrby et al ) despite the fact that the global threat of antibiotic resistance remains a significant problem, particularly for treatment of infections caused by multidrug‐resistant pathogens (Hawken and Snitkin ). Thus, there is an urgent need for alternatives to antibiotics or changes to existing treatment regimes in order to prevent further development of antimicrobial resistance and/or improve the mode of action of current antibiotics.…”
Section: Introductionmentioning
confidence: 99%
“…The rate of discovery and development of new and effective antibiotics has slowed considerably (Norrby et al ) despite the fact that the global threat of antibiotic resistance remains a significant problem, particularly for treatment of infections caused by multidrug‐resistant pathogens (Hawken and Snitkin ). Thus, there is an urgent need for alternatives to antibiotics or changes to existing treatment regimes in order to prevent further development of antimicrobial resistance and/or improve the mode of action of current antibiotics.…”
Section: Introductionmentioning
confidence: 99%
“…During the recent two decades, antimicrobial resistance (AR) in bacteria has been recognized as a critical public health problem (Hawken & Snitkin, 2019). Besides the fundamental utility of antibiotics in improving human health, antibiotics are widely used for treatment and prevention of infections in animals and plants, as well as for promoting growth in animal farming (Cabello, 2006;McManus, Stockwell, Sundin, & Jones, 2002;Singer et al, 2003;Smith, Harris, Johnson, Silbergeld, & Morris, 2002).…”
Section: Introductionmentioning
confidence: 99%
“…Besides the fundamental utility of antibiotics in improving human health, antibiotics are widely used for treatment and prevention of infections in animals and plants, as well as for promoting growth in animal farming (Cabello, 2006;McManus, Stockwell, Sundin, & Jones, 2002;Singer et al, 2003;Smith, Harris, Johnson, Silbergeld, & Morris, 2002). However, during the past two decades, development and spread of AR in many bacteria has been recognized with increasing frequency, and now presents a global health crisis (Hawken & Snitkin, 2019;Wattkins & Bonomo, 2016). Each year in the United States alone, approximately 2 million infections due to AR bacteria occur, resulting in at least 23,000 deaths (Centers for Disease Control & Prevention, 2013).…”
Section: Introductionmentioning
confidence: 99%
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“…In a remarkably short time, whole-genome sequencing (WGS) has fundamentally changed the resolution at which one can study the spread of bacterial pathogens (13). Moreover, through integration of genomic data with epidemiologic metadata, the processes driving the spread of these pathogens can be more clearly understood (14).…”
mentioning
confidence: 99%