Metagenomic Applications for Infectious Disease Testing in Clinical Laboratories

Filkins, Laura; Salais, Robert

doi:10.1007/978-3-030-62155-1_7

Cited by 1 publication

(1 citation statement)

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“…In the global landscape, clinical microbiology, molecular diagnostics, and, more specifically, next-generation sequencing (NGS) have emerged as pivotal areas of focus in the contemporary era. NGS, in particular, holds great promise in the clinical diagnosis of viral and bacterial infections, surpassing conventional diagnostic methods like culture testing and acidfast bacilli staining (AFS) in terms of sensitivity [1,2]. NGS has demonstrated its effectiveness in detecting various viral pathogens, including emerging strains and co-infections during infections [3].…”

Section: Introductionmentioning

confidence: 99%

Emerging Importance of Viral Transport Media in High-Throughput Sequencing Fidelity for Genomic Analysis

Beniwal,

Saharan

2023

JSRR

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The impact of Viral Transport Media (VTM) components on the efficacy and accuracy of high-throughput Next-Generation Sequencing (NGS) techniques is a subject of paramount importance in the field of viral genomics and diagnostics. VTMs play a pivotal role in preserving viral samples, and their composition can profoundly influence the quality and reliability of NGS results. This study explores the intricate relationship between VTM components and NGS outcomes, with a focus on optimizing diagnostic precision and the efficiency of NGS in viral genomics. Through comprehensive investigation, this research sheds light on the critical implications of VTM composition for enhancing viral genomic analysis, streamlining diagnostic processes, and bolstering public health responses. The findings have far-reaching consequences, including the potential for personalized medicine, rapid detection of emerging viral threats, and the improvement of public health surveillance. Standardized protocols and ongoing technological advancements are essential in harnessing the full potential of NGS for genomics and metagenomics, marking a significant step toward more effective viral disease management and outbreak response.

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Section: Introductionmentioning

confidence: 99%