Rapid preparation and characterization of chitosan nanoparticles for oligonucleotide

Cheng, Mu-Hua; Huang, Yao‐Xiong; Zhou, Han-jian; Zhi, Lin; Li, Jianfang

doi:10.1016/j.cap.2009.09.017

Cited by 11 publications

(4 citation statements)

References 16 publications

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“…Chitosan nanoparticles can be prepared using (i) ionic cross-linking, (ii) covalent cross-linking [15], (iii) precipitation [16], (iv) polymerization [17], or (v) self-assembly methods [18], with sizes ranging from 20 to 800 nm dependent on the method of preparation. Chitosan-drug complexes are generally formed via electrostatic interactions between cationic chitosan and anionic drugs [19,20]. For example, Cheng et al [19] prepared chitosan nanoparticles linked with antisense oligonucleotide to produce particles with a size of 102.6 ± 12.0 nm, zeta potential of 1.45 ± 1.75 mV, and an encapsulation efficiency of 87.6 ± 3.5%.…”

Section: Nanoparticles For Topical Therapymentioning

confidence: 99%

“…Chitosan-drug complexes are generally formed via electrostatic interactions between cationic chitosan and anionic drugs [19,20]. For example, Cheng et al [19] prepared chitosan nanoparticles linked with antisense oligonucleotide to produce particles with a size of 102.6 ± 12.0 nm, zeta potential of 1.45 ± 1.75 mV, and an encapsulation efficiency of 87.6 ± 3.5%. Kim et al [20] increased the solubility of retinol by more than 1600-fold by encapsulating it into chitosan nanoparticles.…”

Section: Nanoparticles For Topical Therapymentioning

confidence: 99%

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Nanoparticles and nanofibers for topical drug delivery

Goyal

Macri

Kaplan

et al. 2016

Journal of Controlled Release

443

227

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This review provides the first comprehensive overview of the use of both nanoparticles and nanofibers for topical drug delivery. Researchers have explored the use of nanotechnology, specifically nanoparticles and nanofibers, as drug delivery systems for topical and transdermal applications. This approach employs increased drug concentration in the carrier, in order to increase drug flux into and through the skin. Both nanoparticles and nanofibers can be used to deliver hydrophobic and hydrophilic drugs and are capable of controlled release for a prolonged period of time. The examples presented provide significant evidence that this area of research has—and will continue to have — a profound impact on both clinical outcomes and the development of new products.

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Section: Nanoparticles For Topical Therapymentioning

confidence: 99%

Section: Nanoparticles For Topical Therapymentioning

confidence: 99%

Nanoparticles and nanofibers for topical drug delivery

Goyal

Macri

Kaplan

et al. 2016

Journal of Controlled Release

443

227

View full text Add to dashboard Cite

show abstract

“…It is difficult to prepare for nanoparticles due to its characteristic of poor solubility in water that is within the range of physiological potential of hydrogen (pH) [5]. This poor solubility of the Chitosan is the major limiting factor in medicament utilization, because transporting the target vaccine into cells requires the use of dissoluble Chitosan with positive charge in aqueous [6].…”

Section: Introductionmentioning

confidence: 99%

Preparation and Characterization of 2-Hydroxypropyltrimcthyl Ammonium Chloride Chitosan

Jin

Zhao

Chen

et al. 2011

AMR

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Chitosan has the potential to act as mediators of DNA transfection targeted to phagocytic cells such as macrophages, and to protect against biological degradation by nucleases as well as enhance gene expression. However, the poor solubility of Chitosan is the major limiting factor in its utilization. 2-hydroxypropyltrimcthyl ammonium chloride Chitosan has be prepared successfully through covalent binding of 2,3-Epoxypropyltrimethylammonium chloride ligands to the polymer’s primary amino groups and the polymer’s structure was verified with FT-IR spectra and NMR spectra. The new polymers were obtained with degree of quaternization (DQ) values around 34%, except in the case of the Phe-derived polymer, and thus possess reduced net positive charge as compared to the parent Chitosan. This study provided the new peptide-Chitosans with full water-solubility over practically the entire physiological pH range and led to more disordered. Globally, the new peptide Chitosans and especially the Asp-derived polymer, possess physico-chemical properties that turn them into promising candidates as novel Chitosan-based vaccine delivery systems.

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“…In general, chitosan is dissolved in acetic acid solution [9][10]. The usage of acetic acid as a solvent may make amino groups of chitosan protonated with no possibility to donate electrons, which makes against side group attachment to amino groups.…”

Section: Fabrication Of Csma Csma-cs and Cs-ma Membranesmentioning

confidence: 99%