Rapid determination of 9 aromatic amines in mainstream cigarette smoke by modified dispersive liquid liquid microextraction and ultraperformance convergence chromatography tandem mass spectrometry

Deng, Huimin; Yang, Fei; Li, Zhonghao; Bian, Zhaoyang; Fan, Ziyan; Wang, Ying; Liu, Shanshan; Tang, Gangling

doi:10.1016/j.chroma.2017.05.056

Cited by 27 publications

(16 citation statements)

References 32 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Several works have reported the determination of some aromatic amines in complex matrix at the trace level , which might bring potential quantitative errors originating from the coeffluent with their isomers on chromatography. Complete chromatographic separation of isomers is a premise for their quantitative analysis, although that of some isomers is still a big challenge to analysts .…”

Section: Resultsmentioning

confidence: 99%

“…Several works have reported the determination of some aromatic amines in complex matrix at the trace level [9][10][11][12][13][14][15][16][17][18][19][20][21][22][23][24], which might bring potential quantitative errors originating from the coeffluent with their isomers on chromatography.…”

Section: Separations Of Isomeric Substituted Anilinesmentioning

confidence: 99%

“…Pretreatment is essential for the chromatographic determination of aromatic amines in real samples with complex matrices. Several sample preparation methods, such as SPE [9][10][11][12], liquid-phase sorbent trapping [13], SPME [14][15][16][17][18], magnetic SPE [19], and liquid-liquid microextraction [20][21][22][23][24], have been developed to reduce interference and to improve sensitivity in the determination of aromatic amines. Determination of these weak organic bases often requires derivatization before GC or LC analysis, due to their liability to peak tailing or little retention in the reversed-phase LC setup that may deteriorate their resolution.…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Simultaneous determination of isomeric substituted anilines by imidization with benzaldehyde and gas chromatography–mass spectrometry

Chen

Zhu

Wang

et al. 2017

J of Separation Science

View full text Add to dashboard Cite

The chromatographic separation of several isomeric anilines is a challenging issue. Herein, a simple method for the simultaneous determination of four groups of isomeric primary aromatic amines, including chloroanilines, methylanilines, methoxylanilines, and dimethylanilines, was presented. In this method, all of the 15 primary aromatic amines were easily transformed into the corresponding imine derivative by treatment with benzaldehyde under mild conditions. The formed isomeric imine derivatives were completely separated on a commercial capillary gas chromatography column. The effects of several derivatization parameters were investigated and optimized. Linearity in the optimized method ranged from 0.050 to 50 μg/mL with the squared correlation coefficients (R ) between 0.9981 and 0.9999. Reasonable reproducibility was obtained, with the intraday relative standard deviation (N = 5) ranging from 0.89 to 4.57% and interday relative standard deviation ranging from 2.26 to 7.69% at the concentration of 5.0 μg/mL. The developed method has been successfully applied to determine these isomeric aromatic amines in real samples.

show abstract

Section: Resultsmentioning

confidence: 99%

Section: Separations Of Isomeric Substituted Anilinesmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Simultaneous determination of isomeric substituted anilines by imidization with benzaldehyde and gas chromatography–mass spectrometry

Chen

Zhu

Wang

et al. 2017

J of Separation Science

View full text Add to dashboard Cite

show abstract

“…[17][18][19][20] The combination of UPC 2 and MS/MS could further improve the sensitivity of method. The system has been improved on the traditional SFC and can use columns of sub-2 μm fully porous particles to achieve better and faster separation with good repeatability and stability.…”

Section: Introductionmentioning

confidence: 99%

Ultra‐performance convergence chromatography with tandem mass spectrometry‐assisted method for rapid enantioseparation and determination of fluazifop‐butyl in tobacco and soil

et al. 2019

Self Cite

View full text Add to dashboard Cite

A quick, green, and sensitive method for chiral separation and determination of fluazifop-butyl enantiomers in tobacco and soil was established by ultraperformance convergence chromatography with tandem mass spectrometry (UPC 2 -MS/MS). The baseline separation was obtained on an ACQUITY UPC 2 Trefoil CEL2 column in 4 minutes with CO 2 and methanol as mobile phase. Column temperature, auto back pressure regulator pressure (ABPR), and modifier solvent were optimized to obtain the best separation efficiency.Under the optimal conditions, the recoveries of both enantiomers were 82.8% to 99.5% with relative standard deviations (RSDs) less than 5.5% at three different concentration levels in two matrices. Good coefficients of determination (R 2 ≥ 0.9976) were achieved over the concentration range of 10 to 500 ng/mL. The limits of detection (LODs) for all enantiomers in the two matrices varied from 1.6 to 2.1 μg/kg, and the limits of quantification (LOQs) did not exceed 7.0 μg/kg. The proposed method was then successfully applied to analyze authentic samples, confirming that it was a green, convenient, and reliable strategy for the analysis of fluazifop-butyl enantiomers in tobacco and soil.

show abstract

“…These particles can achieve faster separation by using higher flow than sub-5 m particles. The sensitivity of the method is improved greatly by combining UPC 2 and MS/MS [21][22][23][24].…”

Section: Introductionmentioning

confidence: 99%

An environmentally friendly method for the enantioseparation and determination of benalaxyl in tobacco and soil by ultra‐performance convergence chromatography with tandem mass spectrometry

Yang

Tang

et al. 2018

J of Separation Science

Self Cite

View full text Add to dashboard Cite

For the purpose of chiral separation and determination of benalaxyl enantiomers in tobacco and soil, we developed a rapid, green, and sensitive method using ultra-performance convergence chromatography with tandem mass spectrometry. The samples were extracted and purified by the quick, easy, cheap, effective, rugged, and safe method before injection. The baseline separation was obtained on a chiral column in 5 min with carbon dioxide and ethanol as mobile phase. Separation parameters were optimized for the best separation efficiency. Under optimal conditions, the recoveries of both enantiomers were 77.1-98.4% with relative standard deviations <5.0% at spiked level of 0.1, 2.0, and 5.0 mg/kg in two matrices. Good coefficients of determination were achieved over the concentration range of 10-250 ng/mL. The limit of detection and the limit of quantification for all enantiomers ranged from 0.43 to 0.72 μg/kg and from 1.25 to 2.15 μg/kg, respectively. The results show that ultra-performance convergence chromatography with tandem mass spectrometry provides a reliable, green, and rapid method for the separation and determination of benalaxyl enantiomers in tobacco and soil. This method has important theoretical significance for studying the enantioselectivity and bioactivity of benalaxyl in the environment and in organisms.

show abstract

Rapid determination of 9 aromatic amines in mainstream cigarette smoke by modified dispersive liquid liquid microextraction and ultraperformance convergence chromatography tandem mass spectrometry

Cited by 27 publications

References 32 publications

Simultaneous determination of isomeric substituted anilines by imidization with benzaldehyde and gas chromatography–mass spectrometry

Simultaneous determination of isomeric substituted anilines by imidization with benzaldehyde and gas chromatography–mass spectrometry

Ultra‐performance convergence chromatography with tandem mass spectrometry‐assisted method for rapid enantioseparation and determination of fluazifop‐butyl in tobacco and soil

An environmentally friendly method for the enantioseparation and determination of benalaxyl in tobacco and soil by ultra‐performance convergence chromatography with tandem mass spectrometry

Contact Info

Product

Resources

About