Rapid communication: MspI restriction fragment length polymorphism at the swine MYF6 locus2

Ernst, Catherine W.; Vaske, D. A.; Larson, R. G.; White, Michael E.; Rothschild, Max F.

doi:10.2527/1994.723799x

Cited by 8 publications

(7 citation statements)

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“…2006); however, no association with growth, carcass or meat‐quality traits has been found. Currently, there are polymorphisms known in MYOD1 and MYF6 , but reports about association are mostly negative or not consistent (Ernst et al 1994; Urbansky & Kuryl 2004; Wyszynska‐Koko & Kuryl 2004; Wyszynska‐Koko et al 2006). To select candidate genes for meat quality, loci with stage‐ or breed‐specific expression during myogenesis have been identified employing microarrays, suppression subtractive hybridization (SSH) and differential‐display reverse transcription PCR (DD‐RT‐PCR) in two breeds, Duroc and Pietrain, which display divergence in meat‐quality and muscularity traits.…”

Section: Introductionmentioning

confidence: 99%

Associations of functional candidate genes derived from gene‐expression profiles of prenatal porcine muscle tissue with meat quality and muscle deposition

et al. 2007

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Ten genes (ANK1, bR10D1, CA3, EPOR, HMGA2, MYPN, NME1, PDGFRA, ERC1, TTN), whose candidacy for meat-quality and carcass traits arises from their differential expression in prenatal muscle development, were examined for association in 1700 performance-tested fattening pigs of commercial purebred and crossbred herds of Duroc, Pietrain, Pietrain x (Landrace x Large White), Duroc x (Landrace x Large White) as well as in an experimental F(2) population based on a reciprocal cross of Duroc and Pietrain. Comparative sequencing revealed polymorphic sites segregating across commercial breeds. Genetic mapping results corresponded to pre-existing assignments to porcine chromosomes or current human-porcine comparative maps. Nine of these genes showed association with meat-quality and carcass traits at a nominal P-value of < or = 0.05; PDGFRA revealed no association reaching the P < or = 0.05 threshold. In particular, HMGA2, CA3, EPOR, NME1 and TTN were associated with meat colour, pH and conductivity of loin 24 h postmortem; CA3 and MYPN exhibited association with ham weight and lean content (FOM) respectively at P-values of < 0.003 that correspond to false discovery rates of < 0.05. However, none of the genes showed significant associations for a particular trait across all populations. The study revealed statistical-genetic evidence for association of the functional candidate genes with traits related to meat quality and muscle deposition. The polymorphisms detected are not likely causal, but markers were identified that are in linkage disequilibrium with causal genetic variation within particular populations.

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Section: Introductionmentioning

confidence: 99%

Associations of functional candidate genes derived from gene‐expression profiles of prenatal porcine muscle tissue with meat quality and muscle deposition

et al. 2007

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“…Myf5 expression first appeared in the stage 3 primitive streak of chicken embryo muscle development, and showed transient lower levels of expression in non-muscle mesoderm. Thereafter, Myf5 was concurrently expressed with the occurrence of the sarcomere germ layers in the pre-sub section (pre-segmented mesoderm), and showed dynamic regional expression changes in the I-IV somite (Ernst et al, 1994;Black et al, 1995;Goureau et al, 2001). Up-and downregulation experiments have revealed that Myf5 plays a critical role in the myogenic process of vertebrates, especially in the muscle differentiation stage (Tatusova and Madden, 1999).…”

Section: Discussionmentioning

confidence: 99%

Myf5 gene polymorphisms and production performance traits in Songliao white geese

Wu¹,

Cao²,

Li³

et al. 2013

Genet. Mol. Res.

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ABSTRACT. To explore the relationship between Myf5 gene polymorphisms and production performance traits in Songliao white geese, we used the chicken Myf5 sequence to design primers and amplified part of the exon 1 sequence of the Songliao white goose Myf5 gene. Results of single-strand conformation polymorphism polymerase chain reaction analysis revealed polymorphisms of the amplified fragment, including three genotypes (AA, AB, and BB). Three varieties were dominated by allele A and were mainly expressed in AA genotypes. We also identified that the Myf5 gene has one single nucleotide change (A→G) on exon 1 at locus 1344, and another (G→C) at locus 1410. Analysis of variance showed significant differences between genotypes before slaughter in live weight, carcass weight, eviscerated weight, leg muscle weight, weight of the wings, and slaughter rate. There were no significant differences with respect to other growth and carcass traits evaluated.

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“…Extensive investigations lead to the detection of several polymorphisms in both genes in swine and cattle, respectively. However, association analyses mostly revealed contradictory results in different lines and breeds or failed to show any relationship to production traits (Ernst et al, 1994;Stratil and Cepica, 1999;Te Pas et al, 1999;Drogemuller and Kempers, 2000;Cieslak et al, 2002;Li et al, 2002;Urbanski and Kuryl, 2004). Most of these described single nucleotide polymorphisms (SNPs) are located within introns, and therefore are considered as markers for not yet identified causative mutations.…”

Section: Introductionmentioning

confidence: 93%

Identification and analysis of putative regulatory sequences for the MYF5/MYF6 locus in different vertebrate species

Maak

Neumann

Swalve

2006

Gene

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Rapid communication: MspI restriction fragment length polymorphism at the swine MYF6 locus2

Abstract: Source and Description of Probe. A 1,296-bp rat cDNA clone for MRF4 (also called MYF6) was excised from the EcoRI site of the plasmid pBluescript KS+ (Rhodes and Konieczny, 1989

Cited by 8 publications

References 0 publications

Associations of functional candidate genes derived from gene‐expression profiles of prenatal porcine muscle tissue with meat quality and muscle deposition

Associations of functional candidate genes derived from gene‐expression profiles of prenatal porcine muscle tissue with meat quality and muscle deposition

Myf5 gene polymorphisms and production performance traits in Songliao white geese

Identification and analysis of putative regulatory sequences for the MYF5/MYF6 locus in different vertebrate species

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