Identification and analysis of putative regulatory sequences for the MYF5/MYF6 locus in different vertebrate species

Maak, Steffen; Neumann, Karsten; Swalve, Hermann H.

doi:10.1016/j.gene.2006.05.007

Cited by 36 publications

(32 citation statements)

References 33 publications

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“…The MYF5 gene plays a key regulatory role in the initiation and development of skeletal muscle and the maintenance of its phenotype, and is thus a candidate gene for involvement in traits related to growth and meat quality (Maak et al, 2006). In our study we constructed and used the MYF5-p1 primer to identify a novel SNP, the Hsp92II polymorphic loci, an adenine to cytosine shift resulting in a methionine (ATG) to leucine (CTG) amino acid substitu- (172) tion in exon 1 of the MYF5 gene and investigated this polymorphism and the previously reported intron 1 HinfI polymorphism (te Pas et al, 1999) in two populations (n = 324).…”

Section: Discussionmentioning

confidence: 99%

Associations of MYF5 gene polymorphisms with meat quality traits in different domestic pig (Sus scrofa) populations

Liu

Peng

et al. 2007

Genet. Mol. Biol.

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The MYF5 gene is first inducibly expressed in muscle cell during embryonic muscle development and plays an important role in regulating the differentiation of skeletal muscle precursors. In this study we used PCR-RFLP to investigate two pig (Sus scrofa) populations (n = 302) for two MYF5 gene polymorphisms, a previously unreported novel Met-Leu shift single nucleotide polymorphism (SNP) MYF5/Hsp92II located on exon 1 and the previously identified intron 1 MYF5/HinfI SNP. Haplotype and association analysis showed that haplotypes of the two SNPs were significantly associated with drip loss rate (DLR, p < 0.05), water holding capacity (WHC, p < 0.05), biceps femoris meat color value (MCV2, p < 0.05), biceps femoris marbling score (MM2, p < 0.01), longissimus dorsi intramuscular fat percentage (IMF, p < 0.01) and longissimus dorsi Water moisture content (WM, p < 0.01) in the population 2. However, further studies are needed to confirm these preliminary results.

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Section: Discussionmentioning

confidence: 99%

Associations of MYF5 gene polymorphisms with meat quality traits in different domestic pig (Sus scrofa) populations

Liu

Peng

et al. 2007

Genet. Mol. Biol.

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“…Maak et al (2006) conducted an in-depth comparative study of Myf5, demonstrating that various regulatory factors within the region of the gene in mice, rabbits, pigs, cattle, dogs, and chickens (H1 and 2; M6EH) were all highly conserved. The function of these regulatory factors has been determined in transgenic mice, which are all temporally and spatially expressed independently in different regions during mouse embryo development (Williams et al, 1990;Welsh et al, 1991;Yablonka-Reuveni et al, 1999).…”

Section: Discussionmentioning

confidence: 99%

Myf5 gene polymorphisms and production performance traits in Songliao white geese

Wu¹,

Cao²,

Li³

et al. 2013

Genet. Mol. Res.

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ABSTRACT. To explore the relationship between Myf5 gene polymorphisms and production performance traits in Songliao white geese, we used the chicken Myf5 sequence to design primers and amplified part of the exon 1 sequence of the Songliao white goose Myf5 gene. Results of single-strand conformation polymorphism polymerase chain reaction analysis revealed polymorphisms of the amplified fragment, including three genotypes (AA, AB, and BB). Three varieties were dominated by allele A and were mainly expressed in AA genotypes. We also identified that the Myf5 gene has one single nucleotide change (A→G) on exon 1 at locus 1344, and another (G→C) at locus 1410. Analysis of variance showed significant differences between genotypes before slaughter in live weight, carcass weight, eviscerated weight, leg muscle weight, weight of the wings, and slaughter rate. There were no significant differences with respect to other growth and carcass traits evaluated.

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“…Genes may be derived from physiological or genomic information. One such example is shown by Maak et al (2006) who performed a comparative sequence analysis of the myogenic factors (MYF) 5 or 6 locus in swine, cattle, dog, chicken and zebrafish on the basis of Rehfeldt, Te Pas, Wimmers, Brameld, Nissen, Berri, Valente, Power, Picard, Stickland and Oksbjerg structural and functional information from human and mouse. As the MYF5 and MYF6 are integral to the initiation and development of skeletal muscle and to the maintenance of its phenotype, these genes may be important candidate genes.…”

Section: Qtl and Polymorphisms In Candidate Genesassociations With Mumentioning

confidence: 99%

Advances in research on the prenatal development of skeletal muscle in animals in relation to the quality of muscle-based food. II – Genetic factors related to animal performance and advances in methodology

Rehfeldt

Pas

Wimmers

et al. 2011

Animal

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Selective breeding is an effective tool to improve livestock. Several selection experiments have been conducted to study direct selection responses as well as correlated responses in traits of skeletal muscle growth and function. Moreover, comparisons of domestic with wild-type species and of extreme breeds provide information on the genetic background of the skeletal muscle phenotype. Structural muscular components that differed with increasing distance in lean growth or meat quality in mammals were found to be myofibre number, myofibre size, proportions of fibre types as well as the numbers and proportions of secondary and primary fibres. Furthermore, markers of satellite cell proliferation, metabolic enzyme activities, glycogen and fat contents, the expression of myosin heavy chain isoforms, of activated AMPKa and other proteins in skeletal muscle tissue and circulating IGF1 and IGF-binding proteins have been identified to be involved in selection responses observed in pigs, cattle and/or chicken. The use of molecular methods for selective breeding of fish has only recently been adopted in aquaculture and studies of the genetic basis of growth and flesh quality traits are scarce. Some of the molecular markers of muscle structure/metabolism in livestock have also been identified in fish, but so far no studies have linked them with selection response. Genome scans have been applied to identify genomic regions exhibiting quantitative trait loci that control traits of interest, for example, muscle structure and meat quality in pigs and growth rate in chicken. As another approach, polymorphisms in candidate genes reveal the relationship between genetic variation and target traits. Thus, in large-scale studies with pigs' associations of polymorphisms in the HMGA2, CA3, EPOR, NME1 and TTN genes with traits of carcass and meat quality were detected. Other studies revealed the significance of mutations in the IGF2 and RYR1 genes for carcass lean and muscle fibre traits in pigs. Mutations in the myostatin (MSTN) gene in fish were also examined. Advances in research of the genetic and environmental control of traits related to meat quality and growth have been made by the application of holistic 'omics' techniques that studied the whole muscle-specific genome, transcriptome and proteome in relation to muscle and meat traits, the development of new methods for muscle fibre typing and the adaptation of biophysical measures to develop parameters of muscle fibre traits as well as the application of in vitro studies. Finally, future research priorities in the field are defined.Keywords: farm animal, fish, skeletal muscle, animal performance, genetic effects ImplicationsSkeletal muscle development in different animal species has been an important topic of scientific research for many years.*Authoring on behalf of all members of the COST action 925: http://www. agrsci.dk/costaction925/index.html -E-mail: rehfeldt@fbn-dummerstorf.de 718The main aim of this review is to present recent knowledge on the genetic components of skele...

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Identification and analysis of putative regulatory sequences for the MYF5/MYF6 locus in different vertebrate species

Cited by 36 publications

References 33 publications

Associations of MYF5 gene polymorphisms with meat quality traits in different domestic pig (Sus scrofa) populations

Associations of MYF5 gene polymorphisms with meat quality traits in different domestic pig (Sus scrofa) populations

Myf5 gene polymorphisms and production performance traits in Songliao white geese

Advances in research on the prenatal development of skeletal muscle in animals in relation to the quality of muscle-based food. II – Genetic factors related to animal performance and advances in methodology

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