Rapid biomimetic remineralization of the demineralized enamel surface using nano-particles of amorphous calcium phosphate guided by chimaeric peptides

Xiao, Zuohui; Que, Kehua; Wang, Haorong; An, Ran; Chen, Zhe; Qiu, Zhongjun; Lin, Mingli; Song, Jinhua J.; Yang, Jie; Lu, Danyang; Shen, Minjuan; Guan, Binbin; Wang, Yinghui; Deng, Xuliang; Yang, Xiaoping; Cai, Qing; Deng, Jiaying; Ma, Li; Zhang, Xi; Zhang, Xu

doi:10.1016/j.dental.2017.07.015

Cited by 64 publications

(80 citation statements)

References 49 publications

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“…10 These approaches are facilitated by the addition of different boosters or supplements in combination with fluoride application. 11,12 In this way, several oral care products available at the market contain, besides fluoride, different active ingredients and make claims promising protection for teeth against enamel demineralization. 13,14 The evolving technology and research on the development of new products aim not only to reduce enamel demineralization but also boost the remineralizing capability of formulations, thus reducing the side effects of conventional fluoride treatments.…”

Section: Introductionmentioning

confidence: 99%

Effects of 1450-ppm Fluoride-containing Toothpastes Associated with Boosters on the Enamel Remineralization and Surface Roughness after Cariogenic Challenge

et al. 2020

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Objectives This in vitro study investigated the remineralization potential of 1450 ppm, fluoride-containing toothpastes containing different active remineralization agents after cariogenic challenge with pH cycling. The enamel surface roughness after brushing and the chemical and physical characteristics of the toothpastes tested were also analyzed. Materials and Methods Fifty-six bovine enamel blocks were obtained (4 × 4 × 6 mm) and divided into three thirds: intact (untreated), demineralized (artificial caries lesion), and treated (caries lesion, pH cycling, and brushing with dentifrices). Seven commercially available fluoride toothpastes (1450 ppm F): three with anti-erosion claims ( Candida Professional [CPP], Colgate Total 12 Daily Repair [CDR], Regenerate Enamel Science [RES]); three with desensitizing claims (Bianco Pro Clinical [BPP], Elmex Sensitive [ESS], and Regenerador Diário DentalClean [RDC]); and one standard regular-fluoride toothpaste Colgate Total 12 (CTT) were selected. During pH cycling (demineralization 6 h/remineralization 18 h) for 7 days, the treated third was brushed with the different dentifrices for 10 minutes in a brushing machine before immersion in a remineralizing solution. The Knoop hardness (25 g, 10 second of the surface, and longitudinal section were then evaluated at eight depths (10 to 330 μm). Mean and percentage of surface hardness recovery (% SHR) were calculated. Surface enamel roughness (Ra) was also evaluated. The pH, %weight of particles, zeta potential, and polydispersity index of toothpaste slurries were also evaluated. Statistical Analysis Data were statistically analyzed (ANOVA/Tukey, 5%). Results The %SHR of CPP was significantly lower than the others (p < 0.05). The enamel subsurface was more effectively remineralized when treated with BPP, ESS, and RDC. The surface roughness was higher when the demineralized third was treated with CTT, RDC, and RES and after the cariogenic challenge (p < 0.05). For some of the products tested, there was no relationship between surface remineralization and subsurface remineralization. Although toothpastes CPP and RDC present the lowest %SHR Abstract Keywords ► enamel ► hardness ► roughness ► toothpaste ► tooth remineralization

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Section: Introductionmentioning

confidence: 99%

Effects of 1450-ppm Fluoride-containing Toothpastes Associated with Boosters on the Enamel Remineralization and Surface Roughness after Cariogenic Challenge

et al. 2020

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“…Many products are following the general criteria of the regenerative medicine in their action. One of the most important concept is the “biomimetism”, the natural ability of a compound to mimicking the physiologic activity of a tissue [ 34 ]. The use of crystals of synthetic hydroxyapatite (carbonate-hydroxyapatite-zinc-acting) ensure to reproduce a “biomimetic” behaviour very similar to the natural component of the tooth.…”

Section: Resultsmentioning

confidence: 99%

Remineralization Strategies in Oral Hygiene: A Position Paper of Italian Society of Oral Hygiene Sciences-S.I.S.I.O. Working Group

Sanavia¹,

Tatullo²,

Bassignani³

et al. 2017

TODENTJ

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Background/Objective:The clinical conditions that lead to an alteration of the enamel structure are numerous. The diet high in sugars and acidifying substances, psychological stress that triggers parafunctional behaviors, the reduced intake of fiber-rich foods or alkalizing substances, together with other factors, contribute to demineralization of the tooth enamel. Dental mineralizing products on the current market are distinguished according to the dosage form, the active ingredient, the release technology, clinical indications and patient choice. Currently, it is necessary to propose to oral health professionals a guide to orient themselves in this chaotic choice, in order to prefer the most effective product for their own clinical target.Methods:Italian Society of Oral Hygiene Sciences-S.I.S.I.O. is one of the leading scientific Italian societies representing those dental hygienists working with high-quality standards and in agreement with scientific evidence: in the last year, the SISIO working group has carried out a study focused on remineralizing agents in dentistry, in order to give an authoritative point of view to indicate a guideline in the decision process of the choice of a remineralizing agent. We will report the results pointed out from the last consensus meeting in 2017.Results:We have reported the good the bad and the ugly have been discussed in a critical discussion of such topic.Conclusion:The SISIO experience has been reported in this position paper with the aim to serve as a useful aid in the daily choice of the clinical steps to perform, when dental professionals need to treat demineralized teeth.

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“…The results displayed that the morphology of the TLL@apatite hNFs was more like flower than the pictures of the Burkholderia cepacia lipase (BCL) (26) and the petals can be seen more obviously. This different morphology as SEM images of hNFs showed may probably attributed to the different nucleation, growth, structure and orientation of apatite (33), which derived from the various binding sites of carboxyl and amino groups with Ca 2+ cation and [PO 4 ] 3− , respectively (34)(35)(36). When TLL proteins dispersed in the aqueous solution containing Ca 2+ cation, [PO 4 ] 3− , [HPO4] 2− , and [H 2 PO 4 ] − , the cations could bind to the carboxyl groups such as Asp and the anions to amino groups such as Lys (36,37).…”

Section: The Characterization Of Tll@apatite Hnfsmentioning

confidence: 98%

Efficient synthesis of vitamin A palmitate in nonaqueous medium using self-assembled lipase TLL@apatite hybrid nanoflowers by mimetic biomineralization

Wang

et al. 2018

Green Chemistry Letters and Reviews

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Rapid biomimetic remineralization of the demineralized enamel surface using nano-particles of amorphous calcium phosphate guided by chimaeric peptides

Cited by 64 publications

References 49 publications

Effects of 1450-ppm Fluoride-containing Toothpastes Associated with Boosters on the Enamel Remineralization and Surface Roughness after Cariogenic Challenge

Effects of 1450-ppm Fluoride-containing Toothpastes Associated with Boosters on the Enamel Remineralization and Surface Roughness after Cariogenic Challenge

Remineralization Strategies in Oral Hygiene: A Position Paper of Italian Society of Oral Hygiene Sciences-S.I.S.I.O. Working Group

Efficient synthesis of vitamin A palmitate in nonaqueous medium using self-assembled lipase TLL@apatite hybrid nanoflowers by mimetic biomineralization

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