Efficient synthesis of vitamin A palmitate in nonaqueous medium using self-assembled lipase TLL@apatite hybrid nanoflowers by mimetic biomineralization

Abstract

Zhang (2018) Efficient synthesis of vitamin A palmitate in nonaqueous medium using self-assembled lipase TLL@apatite hybrid nanoflowers by mimetic biomineralization,

Microbial Production of Retinyl Palmitate and Its Application as a Cosmeceutical

“…Therefore, retinyl palmitate, which is a more stable esterified form of retinol, has been regarded as an alternative to retinol and used as an active ingredient in pharmaceutical and cosmetic products as a potent anti-ageing agent [ 22 ]. So far, retinyl palmitate is available as a product of chemical synthesis; however, the chemical synthesis of retinyl palmitate has drawbacks in terms of low or non-site-specific esterification, the necessity of multistep purification, and extremely corrosive catalysts during esterification [ 23 ]. Microbial synthesis of retinyl palmitate is regarded as a promising alternative to chemical synthesis because of the mildness of the chemical reactions involved, efficiency of the catalytic reaction, and inherently high selectivity [ 24 ].…”

Advances in Recombinant Lipases: Production, Engineering, Immobilization and Application in the Pharmaceutical Industry

“…However, on an industrial scale this system is hazardous because methanol is a flammable chemical. For that reason, there have been attempts to identify or create promoters that achieve equal or even better protein yields [94,96]. Another inducible promoter that has shown promising results is the formaldehyde dehydrogenase 1 gene promoter (pFLD).…”

Ultrasound-assisted intensification of Pickering interfacial biocatalysis preparation of vitamin A aliphatic esters

“…Enzymatic synthesis has recently attracted much attention compared to chemical approaches due to its mild reaction conditions, better catalytic efficiency, and environmentally friendly production mode [37] . A few groups have reported the synthesis of vitamin A palmitate (VAP) by transesterification in a biphasic system or in organic solvent by immobilized lipase [38] , [39] . However, it is a pity that enzyme-catalyzed systems suffer from long reaction times with a relatively low conversion rates.…”