Randomized controlled trial of doxycycline in prevention of recurrent periodontitis in high-risk patients: antimicrobial activity and collagenase inhibition

Antioxidant Activity of Tannin Components from Vaccinium vitis-idaea L.

“…Shapira et al (1991) reported that superoxide formation by peripheral polymorphonuclear leucocytes is increased in rapidly progressive periodontitis patients. The killing of collagenaseproducing bacteria and inhibition of collagenase activity by antibiotics (McCulloch et al 1990) and tea catechin (Makimura et al 1993) may help prevent periodontal disease. Furthermore, periodontal disease-related bacteria including Porphy- romonas and Prevotella species, and A. actinomycetemcomitans are capable of producing collagenase (Robertson et al 1982).…”

“…In the prevention of recurrent periodontitis and refractory periodontitis, some resistance has been noted (McCulloch et al 1990). In the prevention of recurrent periodontitis and refractory periodontitis, some resistance has been noted (McCulloch et al 1990).…”

A systematic review on the effect of systemic antimicrobials as an adjunct to scaling and root planing in periodontitis patients

“…Most patients belonged to hospitals or universities, or were referred for specialized treatment. One study randomly selected their patients from town residents (Soder et al 1990), another selected both university and private patients (McCulloch et al 1990), while most of the studies did not report the patient source. Two studies involved more than one centre (Bain et al 1994, Caton et al 2000).…”

“…Most of the groups for comparison had an initial diagnosis of what can be considered nowadays CP (21 groups). Additionally, five groups were classified as a refractory form of CP (Magnusson et al 1994, Walker et al 1993), two as a recurrent form (Kulkarni et al 1991, McCulloch et al 1990), and one as recalcitrant (Soder et al 1990). The latter group was considered CP, based on the selection criteria and on the severity of the disease, as demonstrated by the mean initial PPD.…”

“…Only few studies reported data on adverse effects, and some studies performed blood tests of the participants (Al Joburi et al 1989, Bain et al 1994, Caton et al 2000). The increase in bacterial resistance was also evaluated in some studies, mostly by culture using whole‐plaque susceptibilities (Chin et al 1988, McCulloch et al 1990, Magnusson et al 1994), disk diffusion (Golub et al 2001), or E ‐test and agar dilution (Caton et al 2000).…”