A systematic review on the effect of systemic antimicrobials as an adjunct to scaling and root planing in periodontitis patients

Abstract

Systemic antimicrobials in conjunction with SRP, can offer an additional benefit over SRP alone in the treatment of periodontitis, in terms of CAL and PPD change, and reduced risk of additional CAL loss. However, differences in study methodology and lack of data precluded an adequate and complete pooling of data for a more comprehensive analyses. It was difficult to establish definitive conclusions, although patients with deep pockets, progressive or 'active' disease, or specific microbiological profile, can benefit more from this adjunctive therapy.

When and How to use Antibiotics in Periodontal Treatment?

“…16,17,18,19 Yapılan çalışmalarda, ek olarak uygulanan antibiyotiğin mekanik tedaviye katkı sağladığı ve antibiyotiklerin bazı özel durumlarda tercih edilebileceği bildirilmiştir. 15,20 Mekanik periodontal tedavinin hangi aşamasında ek antibiyotik kullanılmalıdır? Antibiyotikler; mekanik tedaviye başlamadan önce, mekanik tedavi ile eş zamanlı olarak veya cerrahisiz periodontal tedavinin tamamlandığı ve idame fazına geçildiği aşamada kullanılabilir.…”

Clindamycin and dentistry

“…Although the latest European Federation of Periodontology review, which used evidence based reviews and meta-analysis on several subject areas concluded that conclusive evidence for adjunctive benefits was only available for metronidazole and amoxicillin in combination and for spiromycin. 49 …”

Auxiliary chemical therapies in the treatment of aggressive periodontitis: current aspects

“…Nevertheless, it is still not possible to say what the best antimicrobial agent and treatment protocol that should be recommended. To Herrera et al 9 , spiramycin and the association between amoxicillin and metronidazole together with SRP, demonstrated a statistically significant benefit in PD reduction and CAL gain in deep pockets, respectively. Haffajee et al 8 , found a significant CAL gain in the cases treated with tetracycline and metronidazole.…”

“…In addition, the use of these protocols offers better results in cases of AP, in relation to chronic cases [8][9] . Nevertheless, it is still not possible to say what the best antimicrobial agent and treatment protocol that should be recommended.…”

“…The literature has presented many protocols of periodontal diseases treatment, including chemical adjunctive with conventional therapy (for review [7][8][9] ). The AP, as known, evolves rapidly both by high pathogenicity present biofilm, as by deficient host response 10 .…”