Randomized and Controlled Clinical Trial of Bone Healing After Alveolar Ridge Preservation Using Xenografts and Allografts Versus Plasma Rich in Growth Factors

Stumbras, Artūras; Janužis, Gintaras; Gervickas, Albinas; Kubilius, Ričardas; Juodžbalys, Gintaras

doi:10.1563/aaid-joi-d-19-00179

Cited by 21 publications

(53 citation statements)

References 49 publications

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“…Anitua et al 37 revealed higher bone density values in the PRGF group compared to conventional treatment, which is proven to determine bone quality and implant long‐term success 50 . Hence, PRGF can preserve extraction socket dimensions as well as bone graft material and regenerate better quality newly formed bone 35,37 . A recently performed literature review 42 analyzed extraction socket preservation with various biomaterials and revealed newly formed bone of 24.63% to 47.15% at 5 to 7.5 months.…”

Section: Discussionmentioning

confidence: 99%

“…As previous studies confirmed that PRGF significantly improves bone and soft tissue healing, 37,46‐48 the question arises whether PRGF improves bone regeneration and bone quality when combined with bone graft material. In the recently performed randomized clinical trial 35 analyzed the same study groups regarding bone healing after socket preservation following 3 months after tooth extraction and assessed histomorphometric analysis of bone regeneration.…”

Section: Discussionmentioning

confidence: 99%

“…A randomized, controlled, parallel‐design, and a double‐blinded clinical trial was conducted between January 1, 2018, and January 2020 at the Department of Maxillofacial Surgery, Lithuanian University of Health Sciences, Lithuania. The first part of this study regarding histological findings of regenerated alveolar bone has been previously published 35 . The trial followed the recommendations of the Consolidated Standards of Reporting Trials statement 36 .…”

Section: Methodsmentioning

confidence: 99%

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Three‐dimensional analysis of dimensional changes after alveolar ridge preservation with bone substitutes or plasma rich in growth factors: Randomized and controlled clinical trial

Stumbras

Galindo‐Moreno

Janužis

et al. 2020

Clin Implant Dent Rel Res

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Objectives To evaluate alveolar ridge dimensional changes of different alveolar ridge preservation techniques after 3 months of tooth extraction and to compare the efficacy of autologous plasma rich in growth factor (PRGF) to the bone substitutes in alveolar ridge preservation and sites left to heal spontaneously. Materials and Methods Forty patients requiring tooth extraction in the anterior maxilla were randomly allocated to the four following treatment modalities: spontaneous healing (control), natural bovine bone mineral covered with resorbable native collagen membrane (BBM/CM), freeze‐dried bone allograft covered with resorbable native collagen membrane (FDBA/CM) and PRGF alone. Cone beam computed tomography (CBCT) scans were taken after surgery and 3 months later. The measurements of height and width (at 1, 3, and 5 mm below the crest) were performed after superimposing the 2 consecutive CBCT scans. Results The greatest horizontal alveolar bone resorption at 1 mm below bone crest was observed in the control group (−1.61 ± 1.76 mm, P = .037), whereas the least reduction in width was found in the BBM/CM group (−0.68 ± 0.67 mm, P = .037). The most pronounced alveolar height reduction was observed in the control group (−0.86 ± 0.43 mm), whereas alveolar ridge preservation with BBMC/CM (−0.26 ± 0.91 mm) and PRGF (−0.54 ± 0.86 mm) successfully reduced the alveolar height reduction as compared to the control group. Conclusions Alveolar ridge preservation technique in the esthetic zone using BBM/CM or using PRGF is beneficial to reduce horizontal and vertical bone changes.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

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Three‐dimensional analysis of dimensional changes after alveolar ridge preservation with bone substitutes or plasma rich in growth factors: Randomized and controlled clinical trial

Stumbras

Galindo‐Moreno

Janužis

et al. 2020

Clin Implant Dent Rel Res

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“…По данным рандомизированного исследования A. Stumbras с соавторами, при использовании PRGF объем новообразованной костной ткани к 6 мес. после удаления составлял 46,4±15,2%, а при использовании ксеноматериала, покрытого коллагеновой мембраной -20,3±21,9% [26].…”

Section: результаты гистологического исследованияunclassified

Features of Bone Regeneration of the Jaws Alveolar Ridge Using Hydroxyapatite-Based Material

Дробышев

Redko

Sviridov

et al. 2021

Traumatology and Orthopedics of Russia

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Background. Currently, using of osteointegrated titanium implants has become a key component for restoring lost function in various areas of clinical medicine. The actual issue remains preservation or reconstruction of bone tissue for optimal use of titanium implants in traumatology and orthopedics, as well as in maxillofacial surgery. One of the most common grafts are hydroxyapatite-based material with various inclusions, for example, an antibiotic.The aim of the study is to characterize the regeneration of bone tissue of the jaws alveolar ridge using the hydroxyapatite-based material “Collapan-L” in clinical practice.Material and Methods. The study of the material “Collapan-L” (Intermedapatit, Russia) using involved 30 patients with a diagnosis “chronic periodontitis of the tooth”. Patients underwent complex surgical and orthopedic treatment to restore masticatory function. At the first stage, teeth were removed with the “Collapan-L” material used to preserve the alveolus. 4 months after extraction, dental implantation was performed with simultaneous trephine biopsy from the augmentation zone for histomorphometric analysis. At the stage of implant placement and before prosthetics the stability dynamics was measured.Results. The study involved 42 tissue samples obtained at periods from 9 to 32 weeks after removal. The morphological assessment of bone tissue from the implantation zone determined that after 4 months trabeculae from the newly formed bone, including small fragments of biomaterial, were revealed; at the same time, there were signs of biodegradation of the implanted material fragments, there was no inflammatory infiltrate. After 6 months in a significant part of cases the granules of bone material were not found, which indicates a pronounced osseointegration of the material. In its structure, the formed bone tissue differences barely noticeable from the native one, which allows us to conclude that by the time of 24 weeks, the processes of reparative osteogenesis in the alveolus are completed.Conclusion. Histological examination and assessment of changes in the stability showed that using of bone replacement material after tooth extraction can increase the regenerative potential of bone tissue, avoid additional surgical interventions to increase the volume of bone tissue in the area of future implantation, and the formed bone tissue is close in its structure to the native one.

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“…PRP is recommended for faster delivery and PRF for the stable delivery of factors [ 229 ]. Recently, Stumbras et al performed alveolar ridge preservation using bone substitutes and autologous platelet concentrate, where they found that plasma-rich growth factors perform better than the grafts [ 230 ]. Concentrated growth factor (CGF) has also emerged as an excellent tool for oral regenerative medicine [ 231 , 232 ].…”

Section: Biomimetics In Oral and Maxillofacial Regenerationmentioning

confidence: 99%

Biomimetic Aspects of Oral and Dentofacial Regeneration

et al. 2020

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Biomimetic materials for hard and soft tissues have advanced in the fields of tissue engineering and regenerative medicine in dentistry. To examine these recent advances, we searched Medline (OVID) with the key terms “biomimetics”, “biomaterials”, and “biomimicry” combined with MeSH terms for “dentistry” and limited the date of publication between 2010–2020. Over 500 articles were obtained under clinical trials, randomized clinical trials, metanalysis, and systematic reviews developed in the past 10 years in three major areas of dentistry: restorative, orofacial surgery, and periodontics. Clinical studies and systematic reviews along with hand-searched preclinical studies as potential therapies have been included. They support the proof-of-concept that novel treatments are in the pipeline towards ground-breaking clinical therapies for orofacial bone regeneration, tooth regeneration, repair of the oral mucosa, periodontal tissue engineering, and dental implants. Biomimicry enhances the clinical outcomes and calls for an interdisciplinary approach integrating medicine, bioengineering, biotechnology, and computational sciences to advance the current research to clinics. We conclude that dentistry has come a long way apropos of regenerative medicine; still, there are vast avenues to endeavour, seeking inspiration from other facets in biomedical research.

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Randomized and Controlled Clinical Trial of Bone Healing After Alveolar Ridge Preservation Using Xenografts and Allografts Versus Plasma Rich in Growth Factors

Cited by 21 publications

References 49 publications

Three‐dimensional analysis of dimensional changes after alveolar ridge preservation with bone substitutes or plasma rich in growth factors: Randomized and controlled clinical trial

Three‐dimensional analysis of dimensional changes after alveolar ridge preservation with bone substitutes or plasma rich in growth factors: Randomized and controlled clinical trial

Features of Bone Regeneration of the Jaws Alveolar Ridge Using Hydroxyapatite-Based Material

Biomimetic Aspects of Oral and Dentofacial Regeneration

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