Ramulus mori polysaccharide-loaded PLGA nanoparticles and their anti-inflammatory effects in vivo

Feng, Zian; Song, Peng; Wu, Zhi‐Yong; Jiao, Lina; Xu, Shuwen; Yu, Wenchao; Liu, Zhenguang; Hu, Yuanliang; Liu, Jiaguo; Wu, Yi; Wang, Deyun

doi:10.1016/j.ijbiomac.2021.05.200

Cited by 30 publications

(17 citation statements)

References 52 publications

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“…D. indusiata polysaccharides reduced the production of pro-inflammatory cytokines (TNF-α, IL-1β, IL-6, and IFN-γ) in DSSinduced mice and the relative abundance of pathogenic bacteria (Proteus, Enterobacteriaceae, Bacteroides), and increased the relative abundance of Lactobacillus [121]. Ramulus mori polysaccharides inhibited the secretion of inflammatory cytokines IFN-γ and IL-6 and regulated intestinal microbiota abundance, including that of Firmicutes, Bacteroides, Myxospirillum, and Paraprevotella, and therefore, alleviated DSS-induced colitis in a mouse model [63].…”

Section: Effect On Intestinal Immunity and Inflammatory Responsesmentioning

confidence: 96%

Influence of Natural Polysaccharides on Intestinal Microbiota in Inflammatory Bowel Diseases: An Overview

et al. 2022

Foods

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The incidence of inflammatory bowel disease (IBD) has increased in recent years. Considering the potential side effects of conventional drugs, safe and efficient treatment methods for IBD are required urgently. Natural polysaccharides (NPs) have attracted considerable attention as potential therapeutic agents for IBD owing to their high efficiency, low toxicity, and wide range of biological activities. Intestinal microbiota and their fermentative products, mainly short-chain fatty acids (SCFAs), are thought to mediate the effect of NPs in IBDs. This review explores the beneficial effects of NPs on IBD, with a special focus on the role of intestinal microbes. Intestinal microbiota exert alleviation effects via various mechanisms, such as increasing the intestinal immunity, anti-inflammatory activities, and intestinal barrier protection via microbiota-dependent and microbiota-independent strategies. The aim of this paper was to document evidence of NP–intestinal microbiota-associated IBD prevention, which would be helpful for guidance in the treatment and management of IBD.

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Section: Effect On Intestinal Immunity and Inflammatory Responsesmentioning

confidence: 96%

Influence of Natural Polysaccharides on Intestinal Microbiota in Inflammatory Bowel Diseases: An Overview

et al. 2022

Foods

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“…16,36 Many studies have widely used plant-derived polysaccharides in the treatment of ulcerative colitis and have achieved ideal results in restoring the intestinal microbiome, thereby targeting the dysregulated intestinal barrier and improving the intestinal immune response. [37][38][39][40] The results showed that RGP had a significant protective effect on DSS-induced colitis. RGP could increase body weight index and colon length, decrease DAI score, and ameliorate DSSinduced histopathological damage in the DSS-treated group.…”

Section: Discussionmentioning

confidence: 91%

Rehmannia glutinosa polysaccharides attenuates colitis via reshaping gut microbiota and short‐chain fatty acid production

Dong

Cai

et al. 2022

J Sci Food Agric

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BACKGROUND Ulcerative colitis is a gastrointestinal disease closely related to intestinal epithelial barrier damage and intestinal microbiome imbalance; however, effective treatment methods are currently limited. Rehmannia glutinosa polysaccharide (RGP) is an important active ingredient with a wide range of pharmacological activities, although its protective effect on colitis remains to be explored. In the present study, we verified the in vitro anti‐inflammatory effect of RGP, and observed the ameliorating effect of RGP on dextran sulfate sodium‐induced colitis in mice. RESULTS The results showed that (i) RGP attenuates lipopolysaccharide‐induced overexpression of inflammatory factors in RAW264.7 cells; (ii) RGP improves the pathological damage caused by DSS, including weight loss, increased disease activity index and intestinal tissue ulcers; (iii) RGP improves tight junction proteins to protects the tightness of the intestinal epithelium; (iv) RGP inhibits the expression of inflammatory factors through the nuclear factor‐kappa B pathway, and improved the of intestinal tissues inflammation; and (v) RGP can maintain the species diversity of intestinal microbes, increase the content of short‐chain fatty acids and then restore the imbalance of intestinal microecology. CONCLUSION RGP can improve the intestinal microbiota to strengthen the intestinal epithelial barrier and protect against DSS‐induced colitis. © 2022 Society of Chemical Industry.

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“…A defective intestinal epithelial barrier increases intestinal permeability and plays an essential role in FA development [ 31 ]. When the intestinal barrier is impaired, food allergens are excessively exposed to the mucosal immune system, promoting acute and profound inflammatory immune responses [ 23 , 31 , 32 ]. Therefore, as an important physical barrier, the intestinal epithelium plays a critical role in improving tolerance to potential orally ingested food allergens.…”

Section: Discussionmentioning

confidence: 99%

Amelioration of Ovalbumin-Induced Food Allergy in Mice by Targeted Rectal and Colonic Delivery of Cyanidin-3-O-Glucoside

Zou²,

Liu

2022

Foods

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Targeted rectal and colonic delivery is an effective strategy to exploit the biological functions of polyphenols. This work investigated the anti-food allergy (FA) activity of cyanidin-3-O-glucoside (C3G) delivered by enteric sodium alginate in vivo. The results showed that through targeted rectal and colonic delivery, the C3G showed better results in ameliorating clinical allergic symptoms, diarrhea, and serological indicators including ovalbumin-specific IgE, histamine, and mast cell protease-1. The C3G was more efficient in enhancing the intestinal epithelial barrier by up-regulating the tight junction protein expression and promoting secretory IgA and β-defensin secretion. The improved bioactivity in regulating T helper (Th)1/Th2 immune balance in the intestinal mucosa was also observed. Compared with the intestinal microbiota structure of the model group, targeted rectal and colonic delivery of C3G was able to bring the abundance of Bacteroidota and Firmicutes close to the levels found in normal mice. Furthermore, there was an evident increase in beneficial bacteria in the intestinal flora, such as Lactobacillus and Odoribacter, and a decrease in pathogenic bacteria like Helicobacter and Turicibacter. Therefore, the anti-FA activity of C3G could be increased via targeted rectal and colonic delivery, while the mechanism might be attributed to the regulation of intestinal microecological homeostasis.

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Ramulus mori polysaccharide-loaded PLGA nanoparticles and their anti-inflammatory effects in vivo

Cited by 30 publications

References 52 publications

Influence of Natural Polysaccharides on Intestinal Microbiota in Inflammatory Bowel Diseases: An Overview

Influence of Natural Polysaccharides on Intestinal Microbiota in Inflammatory Bowel Diseases: An Overview

Rehmannia glutinosa polysaccharides attenuates colitis via reshaping gut microbiota and short‐chain fatty acid production

Amelioration of Ovalbumin-Induced Food Allergy in Mice by Targeted Rectal and Colonic Delivery of Cyanidin-3-O-Glucoside

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