Influence of Natural Polysaccharides on Intestinal Microbiota in Inflammatory Bowel Diseases: An Overview

Li, Qi; Li, Linyan; Li, Qiqiong; Wang, Junqiao; Nie, Shaoping; Xie, Mingyong

doi:10.3390/foods11081084

Cited by 15 publications

(9 citation statements)

References 128 publications

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“…The gut microbiota plays an important role in immune metabolism, especially through the influence of metabolites such as SCFAs, bile acids, and amino acids. 36 In the present study, CTX-induction directly triggers changes in the composition of the gut microbiota of mice, as supported by the phenomena of decreased abundance of Bacteroidota and increased abundance of Firmicutes at the phylum level (Fig. 5C).…”

Section: Discussionsupporting

confidence: 74%

Bioactive polysaccharides promote gut immunity via different ways

Huang

et al. 2023

Food Funct.

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Section: Discussionsupporting

confidence: 74%

Bioactive polysaccharides promote gut immunity via different ways

Huang

et al. 2023

Food Funct.

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“…Because gut microbial dysbiosis is often accompanied by abnormal expression of inflammatory cytokines [40], we evaluated the protein levels of TNF-ɑ and IL-6 in colon tissues and confirmed that expression of TNF-ɑ and IL-6 increased in the IBS group compared with the control group (TNF-ɑ: P < 0.01 and IL-6: P < 0.01, respectively). However, treatment of Bifico could restore protein expression to normal levels (TNF-ɑ: the IBS group vs. the IBS + Bifico group: P < 0.05, the control group vs. the IBS + Bifico group: P > 0.05, respectively and IL-6: the IBS group vs. the IBS + Bifico group: P < 0.05, the control group vs. the IBS + Bifico group: P > 0.05, respectively) (Fig.…”

Section: Bifico Reduced the Expression Of Tnf-ɑ And Il-6 In Ibs Micementioning

confidence: 73%

Bifico relieves irritable bowel syndrome by regulating gut microbiota dysbiosis and inflammatory cytokines

et al. 2022

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Purpose Gut microbiota dysbiosis, a core pathophysiology of irritable bowel syndrome (IBS), is closely related to immunological and metabolic functions. Gut microbiota-based therapeutics have been recently explored in several studies. Bifico is a probiotic cocktail widely used in gastrointestinal disorders which relate to the imbalance of gut microbiota. However, the efficacy and potential mechanisms of Bifico treatment in IBS remains incompletely understood. Methods Adopting a wrap restraint stress (WRS) -induced IBS mice model. Protective effect of Bifico in IBS mice was examined through abdominal withdrawal reflex (AWR) scores. 16S rDNA, 1H nuclear magnetic resonance (1H-NMR) and western blot assays were performed to analyze alterations of gut microbiota, microbiome metabolites and inflammatory cytokines, respectively. Results Bifico could decrease intestinal visceral hypersensitivity. Although gut microbiota diversity did not increase, composition of gut microbiota was changed after treatment of Bifico, which were characterized by an increase of Proteobacteria phylum and Actinobacteria phylum, Muribaculum genus, Bifidobacterium genus and a decrease of Parabacteroides genus, Sutterella genus and Lactobacillus genus. Moreover, Bifico elevated the concentration of short-chain fatty acids (SCFAs) and reduced protein levels of interleukin-6 (IL-6) and tumor necrosis factor-α (TNF-α). From further Spearman’s correlation analysis, Bifidobacterium genus were positively correlated with SCFAs including propionate, butyrate, valerate and negatively correlated with IL-6 and TNF-α. Conclusion Bifico could alleviate symptoms of IBS mice through regulation of the gut microbiota, elevating production of SCFAs and reducing the colonic inflammatory response.

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“…It is a high polymer with a molecular weight range of 3.5 kDa to 100 kDa [ 37 ]. Currently, polysaccharides are the most widely studied natural active compounds that enhance innate immunity [ 38 , 39 ]. However, tea pigments, such as TB, have been less studied.…”

Section: Discussionmentioning

confidence: 99%

Theabrownin Isolated from Pu-Erh Tea Enhances the Innate Immune and Anti-Inflammatory Effects of RAW264.7 Macrophages via the TLR2/4-Mediated Signaling Pathway

Zhao

Miao

Shan

et al. 2023

Foods

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Theabrownin (TB) is a tea pigment extracted from Pu-erh Tea. The effects of TB on innate immunity and inflammation are not well understood. Herein, the effects of TB on innate immunity are investigated using RAW264.7 macrophages. We found that TB promoted the proliferation of RAW264.7 macrophages, altered their morphology, enhanced their pinocytic and phagocytic ability, and significantly increased their secretion of nitric oxide (NO) and cytokines, all of which enhanced the immune response. Additionally, TB inhibited the release of inflammatory signals in RAW264.7 macrophages primed with lipopolysaccharide (LPS), implying that TB modulates the excessive inflammation induced by bacterial infection. A Western blot showed that TB could activate the toll-like receptor (TLR)2/4-mediated myeloid differentiation factor 88 (MyD88)-dependent mitogen activated protein kinase (MAPK) and nuclear factor-κB (NF-κB) signaling pathway and the TLR2-mediated phosphoinositide 3-kinase (PI3K)–AKT signaling pathway, enhancing the immune functions of RAW264.7 macrophages. TB also inhibited the phosphorylation of core proteins in the MAPK/NF-κB/PI3K–AKT signaling pathway induced by LPS. In addition, we analyzed the transcriptomes of RAW264.7 macrophages, and a Kyoto encyclopedia of genes and genomes (KEGG) enrichment analysis revealed that TB modulated thetoll-like receptor signal pathway. A gene ontology (GO) enrichment analysis indicated that TB treatment strongly modulated the immune response and inflammation. As a result, TB-enhanced innate immunity and modulated inflammation via the TLR2/4 signaling pathway.

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Influence of Natural Polysaccharides on Intestinal Microbiota in Inflammatory Bowel Diseases: An Overview

Cited by 15 publications

References 128 publications

Bioactive polysaccharides promote gut immunity via different ways

Bioactive polysaccharides promote gut immunity via different ways

Bifico relieves irritable bowel syndrome by regulating gut microbiota dysbiosis and inflammatory cytokines

Theabrownin Isolated from Pu-Erh Tea Enhances the Innate Immune and Anti-Inflammatory Effects of RAW264.7 Macrophages via the TLR2/4-Mediated Signaling Pathway

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