Raman on a disc: high-quality Raman spectroscopy in an open channel on a centrifugal microfluidic disc

Martin, Jacob W.; Nieuwoudt, Michél K.; Vargas, Matheus J. T.; Bodley, Owen; Yohendiran, T. S.; Oosterbeek, Reece N.; Williams, David E.; Simpson, M. Cather

doi:10.1039/c6an00874g

Cited by 15 publications

(8 citation statements)

References 37 publications

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“…The main advantages of SERS are the specificity of the recorded signal and fast analysis . Additionally, it can be combined with miniaturized laboratory concepts for on-site, point-of-need, or point-of-care detection, such as lab-on-a-disc − and lab-on-a-chip systems . The potential of the technology is further supported by the availability of high quality commercial substrates − as well as by the access to miniaturized, portable Raman systems. − …”

Section: Introductionmentioning

confidence: 99%

Quantitative SERS Assay on a Single Chip Enabled by Electrochemically Assisted Regeneration: A Method for Detection of Melamine in Milk

et al. 2020

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Reusability of sensors is relevant when aiming to decrease variation between measurements, as well as cost and time of analysis. We present an electrochemically assisted surface-enhanced Raman spectroscopy (SERS) platform with the capability to reverse the analyte–surface interaction, without damaging the SERS substrate, allowing for efficient sensor reuse. The platform was used in combination with a sample pretreatment step, when detecting melamine from milk. We found that the electrochemically enhanced analyte–surface interaction results in significant improvement in detection sensitivity, with detection limits (0.01 ppm in PBS and 0.3 ppm in milk) below the maximum allowed levels in food samples. The reversibility of interaction enabled continuous measurement in aqueous solution and a complete quantitative assay on a single SERS substrate.

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Section: Introductionmentioning

confidence: 99%

Quantitative SERS Assay on a Single Chip Enabled by Electrochemically Assisted Regeneration: A Method for Detection of Melamine in Milk

et al. 2020

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“…Two vibrational spectroscopic approaches are Raman and mid-infrared (MIR) spectroscopy, where predominantly fundamental vibrations are observed in the spectral range from 4000-200 cm −1 [4]. The limits of detection (LOD) of both spectroscopic techniques have similar values in the three-digit ppm range [5][6][7][8], depending on the setup conditions. Moreover, the identification of molecules is facilitated by the characteristic band positions of the different functional groups and skeletal vibrational motions.…”

Section: Introductionmentioning

confidence: 99%

Comparison of Raman and Mid-Infrared Spectroscopy for Real-Time Monitoring of Yeast Fermentations: A Proof-of-Concept for Multi-Channel Photometric Sensors

et al. 2019

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Raman and mid-infrared (MIR) spectroscopy are useful tools for the specific detection of molecules, since both methods are based on the excitation of fundamental vibration modes. In this study, Raman and MIR spectroscopy were applied simultaneously during aerobic yeast fermentations of Saccharomyces cerevisiae. Based on the recorded Raman intensities and MIR absorption spectra, respectively, temporal concentration courses of glucose, ethanol, and biomass were determined. The chemometric methods used to evaluate the analyte concentrations were partial least squares (PLS) regression and multiple linear regression (MLR). In view of potential photometric sensors, MLR models based on two (2D) and four (4D) analyte-specific optical channels were developed. All chemometric models were tested to predict glucose concentrations between 0 and 30 g L−1, ethanol concentrations between 0 and 10 g L−1, and biomass concentrations up to 15 g L−1 in real time during diauxic growth. Root-mean-squared errors of prediction (RMSEP) of 0.68 g L−1, 0.48 g L−1, and 0.37 g L−1 for glucose, ethanol, and biomass were achieved using the MIR setup combined with a PLS model. In the case of Raman spectroscopy, the corresponding RMSEP values were 0.92 g L−1, 0.39 g L−1, and 0.29 g L−1. Nevertheless, the simple 4D MLR models could reach the performance of the more complex PLS evaluation. Consequently, the replacement of spectrometer setups by four-channel sensors were discussed. Moreover, the advantages and disadvantages of Raman and MIR setups are demonstrated with regard to process implementation.

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“…285 Several interesting articles exist demonstrating the applications of centrifugal microfluidics in SERS. 207,286–288…”

Section: Microfluidic Platforms For Sersmentioning

confidence: 99%

Microfluidics and surface-enhanced Raman spectroscopy, a win–win combination?

et al. 2022

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Raman on a disc: high-quality Raman spectroscopy in an open channel on a centrifugal microfluidic disc

Cited by 15 publications

References 37 publications

Quantitative SERS Assay on a Single Chip Enabled by Electrochemically Assisted Regeneration: A Method for Detection of Melamine in Milk

Quantitative SERS Assay on a Single Chip Enabled by Electrochemically Assisted Regeneration: A Method for Detection of Melamine in Milk

Comparison of Raman and Mid-Infrared Spectroscopy for Real-Time Monitoring of Yeast Fermentations: A Proof-of-Concept for Multi-Channel Photometric Sensors

Microfluidics and surface-enhanced Raman spectroscopy, a win–win combination?

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