Raman Cross Sections of Chemical Agents and Simulants

Christesen, Steven D.

doi:10.1366/0003702884428220

Cited by 62 publications

(51 citation statements)

References 9 publications

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“…However, challenges still remain with amplification of SERS signals due to the extremely small cross-section of Raman scattering. 65 Yan et al intro-duced a new strategy based on nano rolling-circle amplification (nanoRCA) and nano hyper branched rolling circle amplification(nanoHRCA) to increase "hot spot" groups for protein microarrays. 66 Li et al 67 constructed a SERS immune sensor for detection of biomarkers.…”

Section: Biomolecules (Dna Protein and Cell)mentioning

confidence: 99%

Applications of gold nanoparticles in medicine and therapy

Madkour¹

2018

PPIJ

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The stability and dispersity of AuNMs in solution play a key role for the many applications. Most inorganic nanomaterials are not well dispersed in physiological buffers and require function-alization by thiols or surfactants to offer the stabilization forces. Furthermore, sufficient blood circulation time is critical for both imaging and in vivo drug delivery. Localized surface Plasmon resonance (LSPR) is one of the most significant features of AuNMs. The AuNMs as reporters have been broadly applied into lateral flow immunechromatographicalassay (LFICA) and enzyme-linked immunosorbent assay (ELISA), which is a well-established technology for analysis of the target analytes in food safety, clinical diagnosis, environmental monitoring, and medical science and so on. Au based nanomaterials (AuNMs) are known to possess many attractive features such as unique electrical, optical and catalytic properties as well as excellent biocompatibility. In this review, we summarize the current advancement on application of AuNMs in analytical sciences based on their local surface plasmon resonance, fluorescence and electrochemistry properties. AuNMs based imaging and therapy in biomolecules is explained. As one of the most reliable imaging modes, computed tomography (CT), X-ray and SERS imaging has been widely used owing to its high spatial and density resolution. We end the review by a discussion of the conjugation between gold nanoparticles with other kinds of nanoparticles such as other metals and carbon nano structures. Finally, future development in this research area is also prospected.

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Section: Biomolecules (Dna Protein and Cell)mentioning

confidence: 99%

Applications of gold nanoparticles in medicine and therapy

Madkour¹

2018

PPIJ

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“…However, challenges still remain with amplification of SERS signals due to the extremely small cross-section of Raman scattering [59]. Yan et al [60] intro-duced a new strategy based on nano rolling-circle amplification(nanoRCA) and nano hyperbranched rolling circle amplification(nanoHRCA) to increase "hot spot" groups for protein microarrays.…”

Section: Biomoleculesmentioning

confidence: 99%

Advanced AuNMs as nanomedicine’s central goals capable of active targeting in both imaging and therapy in biomolecules

Lh¹

2017

Glob Drugs Therap

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“…An additional factor would be necessary in Eq. 1 if either the sample or reference absorb at the laser wavelength [24].…”

Section: Relative Raman Scattering Cross Sections Of Cwasmentioning

confidence: 99%

“…These compounds are relatively weak Raman scatterers in comparison to the reference compounds. For this reason, the standoff detection of CWAS was an important instrument challenge, as suggested by Christesen [24]. a Data taken from Ref.…”

Section: Relative Raman Scattering Cross Sections Of Cwasmentioning

confidence: 99%

Remote Continuous Wave and Pulsed Laser Raman Detection of Chemical Warfare Agents Simulants and Toxic Industrial Compounds

2010

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This study describes the design, assembly, testing and comparison of two Remote Raman Spectroscopy (RRS) systems intended for standoff detection of hazardous chemical liquids. Raman spectra of Chemical Warfare Agents Simulants (CWAS) and Toxic Industrial Compounds (TIC) were measured in the laboratory at a 6.6 m source-target distance using continuous wave (CW) laser detection. Standoff distances for pulsed measurements were 35 m for dimethyl methylphosphonate (DMMP) detection and 60, 90 and 140 m for cyclohexane detection. The prototype systems consisted of a Raman spectrometer equipped with a CCD detector (for CW measurements) and an I-CCD camera with time-gated electronics (for pulsed laser measurements), a reflecting telescope, a fiber optic assembly, a single-line CW laser source (514.5, 488.0, 351.1 and 363.8 nm) and a frequency-doubled single frequency Nd:YAG 532 nm laser (5 ns pulses at 10 Hz). The telescope was coupled to the spectrograph using an optical fiber, and filters were used to reject laser radiation and Rayleigh scattering. Two quartz convex lenses were used to collimate the light from the telescope from which the telescope-focusing eyepiece was removed, and direct it to the fiber optic assembly. To test the standoff sensing system, the Raman Telescope was used in the detection of liquid TIC: benzene, chlorobenzene, toluene, carbon tetrachloride, cyclohexane and carbon disulfide. Other compounds studied were CWAS: dimethylmethyl phosphonate, 2-chloroethyl ethyl sulfide and 2-(butylamino)-ethanethiol. Relative Raman scattering cross sections of liquid CWAS were measured using single-line sources at 532.0, 488.0, 363.8 and 351.1 nm. Samples were placed in glass and quartz vials at the standoff distances from the telescope for the Remote Raman measurements. The mass of DMMP present in water solutions was also quantified as part of the system performance tests.

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Raman Cross Sections of Chemical Agents and Simulants

Cited by 62 publications

References 9 publications

Applications of gold nanoparticles in medicine and therapy

Applications of gold nanoparticles in medicine and therapy

Advanced AuNMs as nanomedicine’s central goals capable of active targeting in both imaging and therapy in biomolecules

Remote Continuous Wave and Pulsed Laser Raman Detection of Chemical Warfare Agents Simulants and Toxic Industrial Compounds

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