Raised corticomotor excitability of M1 forearm area following anodal tDCS is sustained during robotic wrist therapy in chronic stroke

Edwards, Dylan; Krebs, Hermano Igo; Rykman, Avrielle; Zipse, Johanna; Thickbroom, Gary; Mastaglia, Francis; Pascual‐Leone, Álvaro; Volpe, Bruce T.

doi:10.3233/rnn-2009-0470

Cited by 95 publications

(78 citation statements)

References 57 publications

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“…For example use-dependent modulation and learning of motor skills is modulated by tDCS (Reis and Fritsch, 2011; Madhavan and Shah, 2012). Clinically, tDCS is often applied to enhance the efficacy of rehabilitation or cognitive training (Edwards et al, 2009; Kuo and Nitsche, 2012; Gomez et al, 2013; Leśniak et al, 2013; Ochi et al, 2013), which may further confer functional specificity through activity-selectivity. Clinically when tDCS is applied to subjects at rest, we can speculate that any functional-specificity results from increased sensitivity of pathological network activity to tDCS (e.g., dysfunctional pain or mood regulating networks).…”

Section: Activity-selectivity and Task-specific Modulationmentioning

confidence: 99%

Origins of specificity during tDCS: anatomical, activity-selective, and input-bias mechanisms

Bikson

Rahman

2013

Front. Hum. Neurosci.

324

269

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Transcranial Direct Current Stimulation (tDCS) is investigated for a broad range of neuropsychiatric indications, various rehabilitation applications, and to modulate cognitive performance in diverse tasks. Specificity of tDCS refers broadly to the ability of tDCS to produce precise, as opposed to diffuse, changes in brain function. Practically, specificity of tDCS implies application-specific customization of protocols to maximize desired outcomes and minimize undesired effects. Especially given the simplicity of tDCS and the complexity of brain function, understanding the mechanisms leading to specificity is fundamental to the rational advancement of tDCS. We define the origins of specificity based on anatomical and functional factors. Anatomical specificity derives from guiding current to targeted brain structures. Functional specificity may derive from either activity-selectivity, where active neuronal networks are preferentially modulated by tDCS, or input-selectivity, where bias is applied to different synaptic inputs. Rational advancement of tDCS may require leveraging all forms of specificity.

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Section: Activity-selectivity and Task-specific Modulationmentioning

confidence: 99%

Origins of specificity during tDCS: anatomical, activity-selective, and input-bias mechanisms

Bikson

Rahman

2013

Front. Hum. Neurosci.

324

269

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“…The study in Edwards et al (2009) showed that the increase of corticomotor excitability induced by a period of anodal tDCS was still present whether the brain stimulation was followed by robotic practice.…”

Section: Overview Of the Main Studies On Tdcs Coupled With Upper-limbmentioning

confidence: 99%

Literature Review on the Effects of tDCS Coupled with Robotic Therapy in Post Stroke Upper Limb Rehabilitation

Simonetti

Zollo

Milighetti

et al. 2017

Front. Hum. Neurosci.

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Today neurological diseases such as stroke represent one of the leading cause of long-term disability. Many research efforts have been focused on designing new and effective rehabilitation strategies. In particular, robotic treatment for upper limb stroke rehabilitation has received significant attention due to its ability to provide high-intensity and repetitive movement therapy with less effort than traditional methods. In addition, the development of non-invasive brain stimulation techniques such as transcranial Direct Current Stimulation (tDCS) has also demonstrated the capability of modulating brain excitability thus increasing motor performance. The combination of these two methods is expected to enhance functional and motor recovery after stroke; to this purpose, the current trends in this research field are presented and discussed through an in-depth analysis of the state-of-the-art. The heterogeneity and the restricted number of collected studies make difficult to perform a systematic review. However, the literature analysis of the published data seems to demonstrate that the association of tDCS with robotic training has the same clinical gain derived from robotic therapy alone. Future studies should investigate combined approach tailored to the individual patient's characteristics, critically evaluating the brain areas to be targeted and the induced functional changes.

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“…In this stage, the relative ease of use and portability of tDCS may enable modulation of plasticity via concomitant behavioral interventions such as cognitive behavioral, occupational and physical therapy. 83-86 …”

Section: Noninvasive Brain Stimulation Techniques In the Context Omentioning

confidence: 99%

“…Behavioral gains from rTMS/tDCS protocols may be maximized when brain stimulation is coupled with carefully designed occupational/physical therapy. 83-86 In a pilot study, tDCS has been reported to enhance the effects of upper extremity robotic motor training in TBI patients with no skull defects. 134 …”

Section: Potential Therapeutic Applications Of Noninvasive Brain Smentioning

confidence: 99%

Noninvasive Brain Stimulation in Traumatic Brain Injury

Demirtaş-Tatlıdede

Vahabzadeh‐Hagh²,

Bernabeu³

et al. 2012

Journal of Head Trauma Rehabilitation

137

106

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Brain stimulation techniques have evolved in the last few decades with more novel methods capable of painless, noninvasive brain stimulation. While the number of clinical trials employing noninvasive brain stimulation continues to increase in a variety of medication-resistant neurological and psychiatric diseases, studies evaluating their diagnostic and therapeutic potential in traumatic brain injury (TBI) are largely lacking. This review introduces different techniques of noninvasive brain stimulation, which may find potential use in TBI. We cover transcranial magnetic stimulation (TMS), transcranial direct current stimulation (tDCS), low-level laser therapy (LLLT) and transcranial doppler sonography (TCD) techniques. We provide a brief overview of studies to date, discuss possible mechanisms of action, and raise a number of considerations when thinking about translating these methods to clinical use.

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Raised corticomotor excitability of M1 forearm area following anodal tDCS is sustained during robotic wrist therapy in chronic stroke

Cited by 95 publications

References 57 publications

Origins of specificity during tDCS: anatomical, activity-selective, and input-bias mechanisms

Origins of specificity during tDCS: anatomical, activity-selective, and input-bias mechanisms

Literature Review on the Effects of tDCS Coupled with Robotic Therapy in Post Stroke Upper Limb Rehabilitation

Noninvasive Brain Stimulation in Traumatic Brain Injury

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