Radiotherapy in desmoid tumors

Santti, Kirsi; Beule, Annette; Tuomikoski, Laura; Rönty, Mikko; Jääskeläinen, Anna‐Stiina; Saarilahti, Kauko; Ihalainen, Hanna; Tarkkanen, Maija; Blomqvist, Carl

doi:10.1007/s00066-016-1091-8

Cited by 32 publications

(13 citation statements)

References 38 publications

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“…Radiotherapy may be useful for unresectable or recurrent DF as well as in patients who are at high risk for surgery [61–64]. Further, adjuvant radiotherapy following surgery may also be considered in DF, especially those with positive surgical margins [64].…”

Section: Managementmentioning

confidence: 99%

Current Update on Desmoid Fibromatosis

Ganeshan¹,

Amini

Nikolaidis

et al. 2019

J Comput Assist Tomogr

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Objective: The purpose of this article is to review the etiopathogenesis, molecular cytogenetics, histopathology, clinical features and multimodality imaging features of Desmoid Fibromatosis (DF). Recent advances in the management of Desmoid Fibromatosis will also be discussed. Conclusion: Desmoid Fibromatosis is a rare soft tissue neoplasm with a high incidence of local recurrence. Imaging plays an important role in the diagnosis and management of this disease.

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Section: Managementmentioning

confidence: 99%

Current Update on Desmoid Fibromatosis

Ganeshan¹,

Amini

Nikolaidis

et al. 2019

J Comput Assist Tomogr

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“…In fact, the role of postoperative adjuvant radiotherapy has been controversial in the past few decades. Different studies have come to different conclusions (28)(29)(30)(31). A meta-analysis has indicated that adjuvant radiotherapy can reduce the recurrence rate of patients with positive resection margins, but for patients with negative resection margins, adjuvant radiotherapy cannot reduce recurrence or improve the local control rate (32).…”

Section: Discussionmentioning

confidence: 99%

Development, Validation, and Visualization of A Web-Based Nomogram for Predicting the Recurrence-Free Survival Rate of Patients With Desmoid Tumors

Liu

Huang

et al. 2021

Front. Oncol.

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BackgroundSurgery is an important treatment option for desmoid tumor (DT) patients, but how to decrease and predict the high recurrence rate remains a major challenge.MethodsDesmoid tumor patients diagnosed and treated at Tianjin Cancer Institute & Hospital were included, and a web-based nomogram was constructed by screening the recurrence-related risk factors using Cox regression analysis. External validation was conducted with data from the Fudan University Shanghai Cancer Center.ResultsA total of 385 patients were identified. Finally, after excluding patients without surgery, patients who were lost to follow-up, and patients without complete resection, a total of 267 patients were included in the nomogram construction. Among these patients, 53 experienced recurrence, with a recurrence rate of 20.15%. The 3-year and 5-year recurrence-free survival (RFS) rates were 82.5% and 78%, respectively. Age, tumor diameter, admission status, location, and tumor number were correlated with recurrence in univariate Cox analysis. In multivariate Cox analysis, only age, tumor diameter and tumor number were independent risk factors for recurrence and were then used to construct a web-based nomogram to predict recurrence. The concordance index (C-index) of the nomogram was 0.718, and the areas under the curves (AUCs) of the 3-year and 5-year receiver operating characteristic (ROC) curves were 0.751 and 0.761, respectively. In the external validation set, the C-index was 0.706, and the AUCs of the 3-year and 5-year ROC curves are 0.788 and 0.794, respectively.ConclusionsAge, tumor diameter, and tumor number were independent predictors of recurrence for DTs, and a web-based nomogram containing these three predictors could accurately predict RFS (https://stepforward.shinyapps.io/Desmoidtumor/).

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“…Khorsand and Karakousis 21 reported that radiotherapy reduced the recurrence of MF to 20%–40% compared to 40%–70% reduction achieved with surgery only. Santti et al 22 also concluded that radiotherapy was a valuable option for the treatment of desmoid tumors. In addition, chemotherapy (vincristine, cyclophosphamide, and dactinomycin – either alone or in combination), non-steroidal anti-inflammatory drugs, hormonal manipulation (tamoxifen, aromatase inhibitors, and gonadotropin), and molecular target therapy (imatinib, sorafenib, and sunitinib) may be alternative choices.…”

Section: Discussionmentioning

confidence: 99%

Mesenteric fibromatosis misdiagnosed with lymph node metastasis after successful laparoscopic right hemicolectomy: a report of two cases with review of literature

Wang¹,

Zhou²,

Zhou³

et al. 2018

OTT

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Fibromatosis is a rare type of tumor derived from the mesenchymal tissue. This is a benign tumor with infiltrating growth but may invade locally and recur following excision. As one type of fibromatosis, mesenteric fibromatosis (MF) accounts for a mere 8% of cases. Although studies have revealed that the etiology of MF is related to trauma, surgery, hormones, and heredity, the specific etiology of fibromatosis remains unclear. With such low incidence, MF has been rarely reported and tends to be misdiagnosed due to insufficient recognition. In this paper, we describe the cases of two patients with MF who were misdiagnosed with lymph node metastasis and who had previously undergone successful laparoscopic right hemicolectomy. We provide this information in order to broaden the clinical understanding of MF.

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Radiotherapy in desmoid tumors

Abstract: Radiotherapy is a valuable option for treating desmoid tumors. Radiotherapy dose appears to be significantly associated to local control.

Cited by 32 publications

References 38 publications

Current Update on Desmoid Fibromatosis

Current Update on Desmoid Fibromatosis

Development, Validation, and Visualization of A Web-Based Nomogram for Predicting the Recurrence-Free Survival Rate of Patients With Desmoid Tumors

Mesenteric fibromatosis misdiagnosed with lymph node metastasis after successful laparoscopic right hemicolectomy: a report of two cases with review of literature

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