Radioprotective Effect of Beta  D-Glucan and Vitamin E on Gamma  Irradiated Mouse

Tabeie, Faraj; Tabatabaei, Seyed Mehdi; Mahmoud-Pashazadeh, Ali; Assadi, Majid

doi:10.7860/jcdr/2017/19367.9437

Cited by 5 publications

(2 citation statements)

References 20 publications

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“…For example, β-glucagon and the polysaccharide ginsan have multiple immunomodulatory effects and radioprotective activity (Luo and Luo 2009 ). Moreover, 5-androstenediol, a hormone produced by the adrenal cortex, and vitamins C and E have also been shown to exhibit radioprotective properties (Gonzalez et al 2018 ; Tabeie et al 2017 ; Whitnall et al 2001 ). Some natural compounds including vitamin C, glutamine, arginine, ubiquinone, and hydroquinone have been investigated for their ability to protect the immune system against IR.…”

Section: Naturally Occurring Radioprotectorsmentioning

confidence: 99%

Pharmacology of natural radioprotectors

et al. 2018

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Radiotherapy is one of the most efficient ways to treat cancer. However, deleterious effects, such as acute and chronic toxicities that reduce the quality of life, may result. Naturally occurring compounds have been shown to be non-toxic over wide dose ranges and are inexpensive and effective. Additionally, pharmacological strategies have been developed that use radioprotectors to inhibit radiation-induced toxicities. Currently available radioprotectors have several limitations, including toxicity. In this review, we present the mechanisms of proven radioprotectors, ranging from free radical scavenging (the best-known mechanism of radioprotection) to molecular-based radioprotection (e.g., upregulating expression of heat shock proteins). Finally, we discuss naturally occurring compounds with radioprotective properties in the context of these mechanisms.

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Section: Naturally Occurring Radioprotectorsmentioning

confidence: 99%

Pharmacology of natural radioprotectors

et al. 2018

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“…Single use vitamin A was not utilized; however, it was for vitamin D [ 20 ], which demonstrated anti-inflammatory, antioxidant and radioprotective effects on lacrimal glands in histopathologic and tissue cytokine and oxidant/antioxidant level evaluations in rats. On the other hand, four reviewed vitamins were used in combination (vitamins C and E and β-carotene [ 15 ]; vitamins E and C [ 35 ]; vitamin A, C and E [ 36 ]; and vitamins A, E, C and over-the-counter multivitamins [ 37 ]) or other nutritional (selenium [ 16 ]; copper [ 17 ]; and magnesium sulphate [ 38 ]) and non-nutritional (Haberlea rhodopensis extract [ 18 ]; β-D-glucan [ 39 ]; curcumin [ 40 ]; famotidine and cimetidine [ 41 ]; famotidine [ 42 ]; melatonin [ 43 ]; amifostine and L-carnitine [ 44 ]; and Nigella sativa oil and melatonin [ 45 ]) compounds. The highest protection factor value (4.3) was obtained with vitamin C and famotidine helping to reduce the frequency of micronucleous polychromatic erythrocytes after irradiation [ 42 ].…”

Section: Resultsmentioning

confidence: 99%

Vitamins and Radioprotective Effect: A Review

et al. 2023

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The radioprotective effect ex vivo, in vitro and in vivo of vitamins was reviewed using PubMed and Embase and conducted according to the PRISMA statement. A total of 38 articles were included in this review, which includes the radioprotective effect of vitamins from ex vivo, in vitro and in vivo studies. Vitamins A, C, D and E were used alone, in combination or with other nutritional and non-nutritional compounds. The use of vitamins in natural form or supplementation can be useful to reduce the radiation effect in the body, organs and/or cells. Only four (A, C, D and E) out of thirteen vitamins have been detected with radioprotective properties being mainly vitamin E followed by vitamin C, A and D.

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