In-vivo and in vitro assessments of the radioprotective potential natural and chemical compounds: a review

Javadi, Anis; Nikhbakht, Mohammad Reza; Yadegari, Javad Ghasemian; Rustamzadeh, Auob; Mohammadi, Mohsen; Shirazinejad, Alireza; Azadbakht, Saleh; Abdi, Zahra

doi:10.1080/09553002.2022.2078007

Cited by 3 publications

(3 citation statements)

References 110 publications

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“…To maintain a dynamic balance as a whole, under normal circumstances, reactive oxygen species (ROS) in organisms are in a state of continuous production and removal by the antioxidant system. 31 ROS have the ability to destroy the bilayer membrane structure of cells and damage the structure and function of organelles, thereby causing damage to biological macromolecules such as proteins and lipids. 32 The production of excessive ROS in the intestinal tract of Drosophila , triggered by inflammatory reactions like Sodium dodecyl sulfate (SDS) and ionizing radiation, leads to intestinal cell damage.…”

Section: Resultsmentioning

confidence: 99%

Lactobacillus reuteri's multifaceted role in mitigating ionizing radiation-induced injury in Drosophila melanogaster

Zhang,

Wang,

Jiang

et al. 2024

Food Funct.

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Section: Resultsmentioning

confidence: 99%

Lactobacillus reuteri's multifaceted role in mitigating ionizing radiation-induced injury in Drosophila melanogaster

Zhang,

Wang,

Jiang

et al. 2024

Food Funct.

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“…At present, radiation protection consists mainly of three approaches: physical protection, chemical protection, and biological protection ( Yang et al, 2020 ). Among them, chemical protection is the use of specific compounds or elements to enhance organisms’ tolerance to radiation and reduce the harm caused by radiation ( Andrady et al, 2023 ; Javadi et al, 2023 ).…”

Section: Introductionmentioning

confidence: 99%

Radioprotective effect of polyvinylpyrrolidone modified selenium nanoparticles and its antioxidation mechanism in vitro and in vivo

Li,

Lu,

Jiang

et al. 2024

Front. Bioeng. Biotechnol.

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ObjectivePolyvinylpyrrolidone (PVP) is a commonly used biomedical polymer material with good water solubility, biocompatibility, low immunogenicity, and low toxicity. The aim of this study is to investigate the antioxidant mechanism and clinical potential of PVP modified selenium nanoparticles (PVP-Se NPs) as a new radioprotective agent.MethodsA laser particle size analyzer and transmission electron microscope were used to characterize PVP-Se nanoparticles prepared by chemical reduction. Human umbilical vein endothelial cells (HUVECs) were used to evaluate the radiation protective effects of PVP-Se NPs. SD rats were employed as an in vivo model to identify the most effective concentration of PVP-Se NPs and assess their potential radioprotective properties. Western blot (WB) was used to detect the expression of nuclear factor kappa-B (NF-κB) and mitogen-activated protein kinase (MAPK) signaling proteins in human umbilical vein endothelial cells (HUVECs) and rat liver and kidney tissues.ResultsPVP-Se NPs could reduce the oxidative stress injury and inflammatory response caused by X-ray irradiation in HUVECs and rats, and inhibit cell apoptosis by modulating NF-κB and MAPK signaling pathways. PVP-Se NPs could increase HUVECs viability, reduce apoptosis, inhibit inflammatory factors IL-1β, IL-6 and TNF-α, improve the survival rate of rats, promote antioxidant enzyme activities in cells and rats, reduce malondialdehyde concentration in serum, and reduce the expression of inflammatory factors such as IL-1β, IL-6 and TNF-α in cell supernatant and liver and kidney tissues. PVP-Se NPs could significantly reduce the phosphorylation levels of NF-κB and MAPK pathway-associated proteins in HUVECs and rat liver and kidney tissues (p < 0.05).ConclusionPVP-Se NPs can protect against radiation-induced oxidative damage by modulating NF-kB and MAPK pathways, providing a theoretical basis and experimental data for their use as an effective radioprotective agent.

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“…Consequently, the screening of herbal drugs has become a major focus in the search for new drug discoveries [5]. When exploring the use of natural radioprotectors, it is essential not only to study the active compounds or natural organisms individually but also to investigate preparations or combinations of compounds derived from natural sources [6]. In recent years, the number of publications on these natural preparations has grown exponentially, with literature based on Ayurvedic and Traditional Chinese (or Kamp ō) medicines readily available.…”

Section: Introductionmentioning

confidence: 99%

A Narrative Review of the Herbal Preparation of Ayurvedic, Traditional Chinese, and Kampō Medicines Applied as Radioprotectors

et al. 2023

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In recent years, there has been growing scientific interest in the search for natural radioprotectors that can be used to mitigate the effects of radiation on patients, healthcare personnel, and even for space travel. This narrative review covers the past fifty years and focuses on herbal preparations of Ayurvedic, Traditional Chinese, and Kampō Medicines that have the potential to reduce or eliminate the harmful effects of radiation. Our findings highlight ten herbal preparations, namely Abana, Amalakyadi Churna, Amritaprasham, Brahma, Bu-zhong-yi-qi-tang (BZYQT), Chyavanaprasha, Cystone, Geriforte, Mentat, and Triphala, which have demonstrated potential radioprotective effects. This review examines their composition, properties, and possible mechanisms of action in relation to their radioprotective properties. Exploring the ethnobotany of traditional Asian medicine is particularly interesting as it may lead to the discovery of new active compounds with radioprotective properties.

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In-vivo and in vitro assessments of the radioprotective potential natural and chemical compounds: a review

Cited by 3 publications

References 110 publications

Lactobacillus reuteri's multifaceted role in mitigating ionizing radiation-induced injury in Drosophila melanogaster

Lactobacillus reuteri's multifaceted role in mitigating ionizing radiation-induced injury in Drosophila melanogaster

Radioprotective effect of polyvinylpyrrolidone modified selenium nanoparticles and its antioxidation mechanism in vitro and in vivo

A Narrative Review of the Herbal Preparation of Ayurvedic, Traditional Chinese, and Kampō Medicines Applied as Radioprotectors

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