Radioprotective Activity of Some Medicinal Plant Extracts

Mamedov, Nazim; Rzayev, A. A.; Шамилов, Э. Н.; Abdullaev, A. S.; Rzayeva, I.A.; Gasimova, N.I.; Guliev, G.N.; Craker, Lyle E.

doi:10.17660/actahortic.2011.925.46

Cited by 8 publications

(2 citation statements)

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“…In earlier studies we widely investigated the radioprotective effect of extracts derived from medicinal plants of Azerbaijan [2][3][4][5][6][7][8][9][10].…”

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confidence: 99%

Antiradiation properties of extracts from Hypericum perforatum L.

Шамилов¹,

Abdullaev²,

Shamilli³

et al. 2019

Fakt. eksp. evol. org.

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Aim. Considering the high biological activity of the components of the St. John’s wort, we conducted studies to identify its radioprotective effect. Methods. Studies were conducted on adult Vistar rats with an average weight of 100-120 grams.3 hours before irradiation, the extract from St. John’s wort was intraperitoneally administered to animals at a concentration of 50 mg/kg. Irradiation was carried out once with doses of 5 and 7 Gy on the “Rhund-20000” facility with an average radiation dose rate MD = 0.3069 Gr/s. The frequency of chromosomal abnormalities was recorded on the mitotic cells of the bone marrow. Results. Acute irradiation with a dose of 5 Gy led to cell division inhibition. The number of chromosomal aberrations increased due to structural disorders (deletions, fragments, inversions) up to 6.8%.In animals that received a dose of 7 Gy after a single irradiation, the frequency of chromosomal abnormalities increased to 11.02%. The introduction of the Hypericum perforatum L. extract softened the effect of ionizing radiation, reducing the mutational effect of radiation. It not only contributed to the restoration of the cell division, but also reduced the proportion of structural disorders. Conclusions. Hypericum extract can be considered to be promising as an anti-radiation agent of plant origin. Keywords: rats, chromosomal abnormalities, marrow, irradiation, extract.

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“…In earlier studies we widely investigated the radioprotective effect of extracts derived from medicinal plants of Azerbaijan [2][3][4][5][6][7][8][9][10].…”

mentioning

confidence: 99%

Antiradiation properties of extracts from Hypericum perforatum L.

Шамилов¹,

Abdullaev²,

Shamilli³

et al. 2019

Fakt. eksp. evol. org.

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“…In early studies [3][4][5][6][7][8][9][10][11][12][13][14][15][16][17][18][19], the radioprotective properties of extracts obtained from various medicinal plants of Azerbaijan on the vital activity of plants, higher fungi and mammals were studied.…”

mentioning

confidence: 99%

Studying the radioprotective properties of some phytoextracts from Azerbaijan pharmaceutical flora

Шамилов¹,

Abdullaev²,

Shamilli³

et al. 2018

Fakt. eksp. evol. org.

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Aim. The aim of this work is to evaluate the radioprotective properties of the extract from the flowers of calendula officinalis (Calendula officinalis L.) alone and phytoextracts (CDY) consisting of calendula officinalis (Calendula officinalis), dandelion officinalis (Taráxacum officinále) and yarrow (Achillea millefolium) obtained from medicinal flora of Azerbaijan. Methods. The medicinal plants included in the collection were dried and the extract obtained in a water-alcohol mixture. The extracts were injected intraperitoneally in mice at a concentration of 300 mg / kg 30 min before irradiation at a dose of 9 Gy. Results. It was found out that the extract of calendula possesses radioprotective activity (55%), somewhat inferior to the activity of the protector-standard of cystamine (80%), and phytoextracts (CDY) decreasing the lethal effect of ionizing radiation, has radioprotective activity (62%) and increases survival and life expectancy lethally irradiated mice more than the extract of calendula (55%) and less cystamine (80%). Conclusions. The data obtained by us testify to the prospects of using the extract of calendula separately and in a complex of extracts of dandelion and yarrow in the development of medicinal compositions intended for preventive purposes and in order to prevent local radiation injuries. Keywords: mice, survival, irradiation, extract, cystamine.

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A Multipurpose Medicinal Plant Species: Tinospora cordifolia (Willd.) Miers

Singh

Sharma²

2022

Medicinal and Aromatic Plants of the World

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Radioprotective Activity of Some Medicinal Plant Extracts

Cited by 8 publications

References 0 publications

Antiradiation properties of extracts from Hypericum perforatum L.

Antiradiation properties of extracts from Hypericum perforatum L.

Studying the radioprotective properties of some phytoextracts from Azerbaijan pharmaceutical flora

A Multipurpose Medicinal Plant Species: Tinospora cordifolia (Willd.) Miers

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