Radiopharmaceucticals for cardiovascular imaging

Saha, Gopal B.; Go, Raymundo T.; MacIntyre, William J.

doi:10.1016/0883-2897(92)90179-3

Cited by 21 publications

(12 citation statements)

References 101 publications

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“…1) and 99m Tc(V)-Tetrofosmin have been widely used in clinics for decades, but neither of them meets the requirements of an ideal myocardial perfusion imaging agent. Their high liver uptake and slow clearance from it make it very difficult to interpret the heart activity in the inferior and left ventricular wall [1][2][3][4][5][6][7][8][10][11][12][13]. The complexes in lower oxidation state have been widely studied for the development of new imaging agents.…”

Section: Introductionmentioning

confidence: 99%

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Preparation and biological evaluation of 99mTc-CO-MIBI as myocardial perfusion imaging agent

Chen

Guo

Zhang

et al. 2008

Journal of Organometallic Chemistry

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Section: Introductionmentioning

confidence: 99%

“…Myocardial perfusion imaging with radiotracers plays a very important role in the evaluation of patients with coronary artery disease in clinical practice [1][2][3][4][5][6][7][8][9][10]. 99m Tc(I)-Sestamibi (shown in Fig.…”

Section: Introductionmentioning

confidence: 99%

Preparation and biological evaluation of 99mTc-CO-MIBI as myocardial perfusion imaging agent

Chen

Guo

Zhang

et al. 2008

Journal of Organometallic Chemistry

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“…99m Tc is primarily obtained from 99 Mo/ 99m Tc generator and is eluted as sodium pertechnetate (Na 99m TcO 4 ). In this chemical form, it can be used to study brain and thyroid [7]. Intravenously administered 99m Tc-pertechnetate is loosely bound to plasma proteins and rapidly moves out of the intravenous compartment.…”

Section: Introductionmentioning

confidence: 99%

“…99m Tc is also trapped by the thyroid gland and it passes into the small intestine. However in the brain, the blood-brain barrier prevents Na 99m TcO 4 from entering brain cells [6,7]. …”

Section: Introductionmentioning

confidence: 99%

Sodium pertechnetate (Na99mTcO4) biodistribution in mice exposed to cigarette smoke

Lima

Bernardo-Filho

et al. 2005

BMC Med Phys

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“…The typical administered activity of 99m Tl-thallous chloride was 111 MBq (Mettler et al 1986; Saha et al 1992, 1996; NCRP 1996; Mettler and Guiberteau 1998; Bushberg et al 2002; Kowalsky and Falen 2004), which increased in the late 1990s to 148 MBq (Holly et al 2010; Frank et al 2012; Jafari and Daus 2013). The administered activity of 99m Tc-tetrofosmin was 1110 MBq, 1110 MBq of 99m Tc-sestamibi for the one-day protocol and 1480 MBq for the two-day protocol (NCRP 1996; Mettler and Guiberteau 1998, 2012; Kowalsky and Falen 2004; Mettler et al 2008a, 2008b, Strauss et al 2008; Holly et al 2010; Dorbala et al 2013).…”

Section: Resultsmentioning

confidence: 99%

Use of Radiopharmaceuticals in Diagnostic Nuclear Medicine in the United States

Drozdovitch¹,

Brill²,

Callahan³

et al. 2015

Health Physics

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To reconstruct reliable nuclear medicine-related occupational radiation doses or doses received as patients from radiopharmaceuticals over the last five decades, we assessed which radiopharmaceuticals were used in different time periods, their relative frequency of use, and typical values of the administered activity. This paper presents data on the changing patterns of clinical use of radiopharmaceuticals and documents the range of activity administered to adult patients undergoing diagnostic nuclear medicine procedures in the U.S. between 1960 and 2010. Data are presented for 15 diagnostic imaging procedures that include thyroid scan and thyroid uptake, brain scan, brain blood flow, lung perfusion and ventilation, bone, liver, hepatobiliary, bone marrow, pancreas, and kidney scans, cardiac imaging procedures, tumor localization studies, localization of gastrointestinal bleeding, and non-imaging studies of blood volume and iron metabolism. Data on the relative use of radiopharmaceuticals were collected using key informant interviews and comprehensive literature reviews of typical administered activities of these diagnostic nuclear medicine studies. Responses of key informants on relative use of radiopharmaceuticals are in agreement with published literature. Results of this study will be used for retrospective reconstruction of occupational and personal medical radiation doses from diagnostic radiopharmaceuticals to members of the U.S. radiologic technologist’s cohort and in reconstructing radiation doses from occupational or patient radiation exposures to other U.S. workers or patient populations.

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Radiopharmaceucticals for cardiovascular imaging

Cited by 21 publications

References 101 publications

Preparation and biological evaluation of 99mTc-CO-MIBI as myocardial perfusion imaging agent

Preparation and biological evaluation of 99mTc-CO-MIBI as myocardial perfusion imaging agent

Sodium pertechnetate (Na99mTcO4) biodistribution in mice exposed to cigarette smoke

Use of Radiopharmaceuticals in Diagnostic Nuclear Medicine in the United States

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