Radiomimetic Toxicity of Ozonised Air

Brinkman, R.; Lamberts, H.B.; Veninga, T.S.

doi:10.1016/s0140-6736(64)92221-4

Cited by 80 publications

(9 citation statements)

References 7 publications

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“…The X-ray induced sphering of mammalian erythrocytes including those of man has been demonstrated to be intensified by 03 pretreatment (Brinkman et al, 1964). Teratogenic effects of daily 03 exposures during 3 weeks in mice have been observed (Brinkman et al, 1964;Veninga, 1967).…”

Section: Discussionmentioning

confidence: 99%

“…03 concentrations of 0.2 ppm applied for 3 hrs caused a decrease in visual acuity and an increase in peripheral vision in man (Lagerwerff, 1963). Similar doses of 03 supplied for 3 weeks evoked a decrease in litter size, increased neonatal mortality and an increased incidence of congenital malformations in mice (Brinkman et al, 1964;Dirnagel, 1965). The extrapulmonary manifestation of 03 effects comprises circulatory transport of an active principle.…”

mentioning

confidence: 98%

“…Because preliminary findings in mice which were treated with 03 for longe r periods (Brinkman et al, 1964), gave the impression of increased liver adiposis, the effect of ozone on plasma glutamate pyruvate transaminase (GPT) was examined.…”

mentioning

confidence: 99%

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Extrapulmonary effects of ozone whether in the presence of nitrogen dioxide or not

Veninga

Lemstra

1975

Int. Arch. Arbeitsmed

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Summary. Exposure of mice to 0.2 ppm ozone for 2 hrs induces increments in plasma GPT, in liver ascorbic acid and in the number of binuclear lymphocytes in peripheral blood. The effects are most marked at 2 hrs post exposure.The addition of nitrogen dioxide does not influence the ozone effect on the liver ascorbic acid level. Nitrogen dioxide itself also causes an increase in liver ascorbic acid. These effects are preferentially explained by mobilization of an oxidant reducing system rather than by tissue injury alone.

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Section: Discussionmentioning

confidence: 99%

mentioning

confidence: 98%

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Extrapulmonary effects of ozone whether in the presence of nitrogen dioxide or not

Veninga

Lemstra

1975

Int. Arch. Arbeitsmed

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“…Since ozone action is reportedly radiomimetic and cumulative [16]. even low level exposure over extended periods of time may represent un realized hazards.…”

Section: Discussionmentioning

confidence: 99%

Bronchial Epithelial Alterations and Pulmonary Neoplasia Induced by Ozone

Werthamer¹,

Schwarz²,

Soskind³

1970

Pathobiology

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“…Its presence in polluted areas has led to studies concerning its effects on various biological systems. Ozone has decreased plant productivity [Brennan and Leone, 1968;Feder and Campbell, 1968;Dochinger et al, 19701, increased animal respiratory disorders [Goldsmith and Nadel, 1969;Mueller and Hitchcock, 1969;Jones et al, 1970;Dungworth et al, 19751, and produced radiomimetic effects [Brinkman and Lamberts, 1958;Brinkman et al, 1964;Merz et al, 1975;Gooch et al, 1976;McKenzie et al, 1977;Tice et al, 19781. Also, ozone is known for its mutagenicity in E coli [Hamelin and Chung, 1974;Hamelin, 19751, Vicia faba [Fetner, 1958;Janakiraman and Harney, 19761, hamsters [Zelac et al, 1971a.…”

Section: Introductionmentioning

confidence: 99%

Adult toxicity and dominant lethals induced by ozone at specific stages in spermatogenesis in drosophila virilis

Erdman¹,

Hernández²

1982

Environ. mutagen

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Ozone, a highly reactive three-atom allotrope of oxygen, is formed in high concentrations in various kinds of microenvironments, including electron microscopes, office copy machines, and X-ray devices. Mutagenicity and action modus operandi of ozone suggest its radiomimetic property. In order to test for ozone-induced dominant lethals in Drosophila virilis, we determined that four-hr and longer exposures to 30 +/- 2 ppm ozone were lethal on or before day 25 postexposure. Accordingly, we used a three-hr ozone exposure to investigate dominant lethals induced at specific spermatogenic stages. Ozone increased the percentage of dominant lethals in the stages of spermatogenesis which were investigated. Under the conditions of this experiment, the sperm-sperm bundle stage showed the greatest percentage of dominant lethals induced by ozone. Meiotic cells were the least sensitive to ozone mutagenicity. The induction of dominant lethals is discussed on the basis of chemical reactions from the molecular decomposition of water by radiations and/or ozone. Alternative explanations are presented due to the definition of induced dominant lethals and to associated modifications from ozone exposure.

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Radiomimetic Toxicity of Ozonised Air

Cited by 80 publications

References 7 publications

Extrapulmonary effects of ozone whether in the presence of nitrogen dioxide or not

Extrapulmonary effects of ozone whether in the presence of nitrogen dioxide or not

Bronchial Epithelial Alterations and Pulmonary Neoplasia Induced by Ozone

Adult toxicity and dominant lethals induced by ozone at specific stages in spermatogenesis in drosophila virilis

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