Radiologic findings of primary pulmonary angiosarcoma

Ma, Jun; Zhang, Weiqiang; Huang, Yijuan; Wang, Lizhang; Wang, Jia; Yuan, Ling; Zhang, Jingfeng

doi:10.1097/md.0000000000011105

Cited by 4 publications

(2 citation statements)

References 9 publications

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“…The main CT features include a solitary or multiple lung nodules, interstitial infiltration, diffuse consolidation, GGO, pulmonary nodules surrounding GGO, diffuse pleural thickening, pleural effusion, chest wall invasion, ipsilateral thorax volume loss, hemothorax, pneumothorax and bilateral cystic lung disease ( 5 , 9 , 14-21 ). An endobronchial presentation of a PPA is extraordinarily rare ( 8 , 17 , 22 ).…”

Section: Discussionmentioning

confidence: 99%

Primary pulmonary epithelioid angiosarcoma with thyroid tumor history: A case report and literature review

et al. 2022

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Primary pulmonary epithelioid angiosarcoma is a rare tumor type without any specific clinical and imaging features. Therefore, it is associated with high rates of misdiagnosis. The present study reports the case of a 54-year-old female patient who was admitted after complaining of cough, expectoration and bloody sputum for >5 months in May 2021. The patient reported a previous history of papillary thyroid carcinoma in 2003 and had undergone treatment through surgery, postoperative chemotherapy and iodine 131 therapy. Chest computed tomography (CT) was performed in May 2021, which indicated that the disease had progressed rapidly since February 2021. CT-guided lung biopsy and immunohistochemical staining of the tumor indicated positivity for CD31, CD34 and E26 transformation-specific-related gene markers. The tumor was negative for thyroid cancer-associated antibodies; thus, a diagnosis of primary pulmonary epithelioid angiosarcoma was made. The patient died 3 months after the diagnosis. Primary pulmonary epithelioid angiosarcoma is a rare tumor type with high recurrence and metastasis rates. This tumor has no specific clinical symptoms and signs and is thus easily misdiagnosed. Biopsy is essential for diagnosis of the disease, particularly if patients have a tumor history.

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Section: Discussionmentioning

confidence: 99%

Primary pulmonary epithelioid angiosarcoma with thyroid tumor history: A case report and literature review

et al. 2022

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“…PPA can be either primary or metastatic. Primary PPA is relatively rare, and its CT findings (e.g., intravascular filling defects of contrast agent and narrowing of the luminal space) are similar to those of pulmonary embolism (9). Metastatic lesions from other sites (mainly heart and liver) are more common, accounting for about 60-80% of all PPA cases (10,11).…”

Section: Discussionmentioning

confidence: 99%

Pulmonary angiosarcoma presenting with diffuse alveolar hemorrhage: a case report

Yu¹,

Huang²,

Wang³

et al. 2021

Ann Transl Med

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This study aimed to analyze the diagnosis and treatment of one case of pulmonary angiosarcoma (PPA) retrospectively. The main manifestation of this female patient was cough, hemoptysis and dyspnea.Computed tomography (CT) of the chest revealed multiple small nodules and ground-glass patches in both lungs suggesting of diffuse alveolar hemorrhage (DAH). Laboratory examination revealed decreased hemoglobin and platelet counting, normal coagulation function. Results of rheumatic markers testing including antinuclear antibody (ANA), anti-extractable nuclear antigen antibody (ENA), vasculitis marker, and antiphospholipid antibody were negative. Tumor markers were negative. Sputum smear, sputum culture, and alveolar lavage fluid culture showed negative results. The bone marrow smear was essentially normal.The patient received methylprednisolone pulse therapy (250 mg daily × 5 days) and immunoglobin (20 d daily × 7 days) treatment, but her hemoptysis persisted. Bilateral pleural effusion drainage found a large amount of bloody effusion, but cytology of the pleural fluid showed negative results. The clinical symptoms, laboratory results, imaging findings, and pathological features of the patient were summarized, and problems in diagnosis and treatment were discussed. A thoracoscopic lung biopsy was performed and the diagnosis of PPA was confirmed by pathology and immunohistochemistry (IHC) staining. This case suggested that the possibility of PPA should be considered in patients with DAH, but with negative findings in routine examinations, lung biopsy is usually required.

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