Radioisotopic Study of Anemia in Chronic Renal Disease

Ragen, Patrick A.

doi:10.1001/archinte.1960.00270160016004

Cited by 21 publications

(5 citation statements)

References 11 publications

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“…The red cell utilization of i.v. or orally administered 5gFe is often subnormal in chronic renal failure (2, 12, 13, 19,27,33,37). Concerning the intraindividual utilization of i.v.…”

Section: Discussionmentioning

confidence: 99%

Iron Absorption in Patients with Chronic Renal Failure not Requiring Dialytic Therapy

Milman

Larsen

1975

Journal of Internal Medicine

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Gastrointestinal iron absorption, by means of whole body counting, has been measured in 15 patients with chronic renal failure, not requiring dialysis. Whole body retention 14 days after oral administration of 10 $ 3 59Fe together with a carrier dose of 10 mg Fez+ was taken as expression of absorption. The percentage incorporation in the total erythrocyte mass of administered 59Fe (erythrocyte incorporation) and absorbed 59Fe (red cell utilization) was estimated as well. Iron absorption was 9.6f2.0 (S.D.) % (geometric mean) and erythrocyte incorporation 7.5f2.3 (S.D.) % (geometric mean) while red cell utilization averaged 80.3L-4.8 (S.E.M.) % (arithmetic mean). None of these parameters were significantly different from those obtained in a normal control group (pBO.5, p>0.9 and p>0.2, respectively). The correlation between iron absorption and erythrocyte incorporation was highly significant (r= 1.00, p<0.001). Iron supplementation is often indicated in the investigated category of patients due to increased blood loss and insufficient iron intake and should be given orally in consideration of the normal gastrointestinal absorption.

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“…The red cell utilization of i.v. or orally administered 5gFe is often subnormal in chronic renal failure (2, 12, 13, 19,27,33,37). Concerning the intraindividual utilization of i.v.…”

Section: Discussionmentioning

confidence: 99%

Iron Absorption in Patients with Chronic Renal Failure not Requiring Dialytic Therapy

Milman

Larsen

1975

Journal of Internal Medicine

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“…This is in accordance with the results of Eschbach et al ( 5 ) who also used DF"P-labelling in uraemic patients in chronic dialysis. Some earlier studies, in which labelling with Na2 ,71Cr0, was employed, have shown normal erythrocyte survival in many uraemic patients (9,12), and it is generally accepted that there is a poor correlation between the degree of haemolysis and the severity of uraemia (4, 8).…”

Section: Resultsmentioning

confidence: 99%

SURVIVAL OF DF³²P‐LABELLED ERYTHROCYTES IN URAEMIC PATIENTS DURING EXTRACORPOREAL IRRADIATION OF THE BLOOD

Weeke

Andersen

Dige‐Petersen

et al. 1973

Journal of Internal Medicine

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“…In the literature, there is disagree ment on the existence of a reduced red cell survival in uremic subjects. Thus, R agen et al [12] came to the conclusion that reduced red cell survival is, in chronic renal insufficiency, a rare finding, while D esforges and D awson [4] found it a usual finding. This points out the difficulty in the determination of red cell survival time in chronic renal insufficiency.…”

Section: Red Cell Survivalmentioning

confidence: 99%

Iron Metabolism and Red Cell Survival in Uremic Patients

et al. 1972

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In 12 patients with chronic renal failure, iron utilization and erythropoiesis have been studied byadministration of ⁵⁹Fe and estimation of red cell survival time with ⁵¹Cr. Quantitative studies of the clearance of ⁵⁹Fe from the plasma and its incorporation into the circulating red cell show that erythropoiesis is, in certain cases, effective and in other cases, ineffective. These findings are confirmed by body surface measurements with radioactive iron. Studies with radioactive chromium also show, in certain cases, a normal, and in others, a reduced, survival time of the circulating red cells. Thus, the cause of anemia in uremic patients seems to be due either to a diminished red cell production, hemolysis, or a combination of both.

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Radioisotopic Study of Anemia in Chronic Renal Disease

Cited by 21 publications

References 11 publications

Iron Absorption in Patients with Chronic Renal Failure not Requiring Dialytic Therapy

Iron Absorption in Patients with Chronic Renal Failure not Requiring Dialytic Therapy

SURVIVAL OF DF³²P‐LABELLED ERYTHROCYTES IN URAEMIC PATIENTS DURING EXTRACORPOREAL IRRADIATION OF THE BLOOD

Iron Metabolism and Red Cell Survival in Uremic Patients

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Radioisotopic Study of Anemia in Chronic Renal Disease

Cited by 21 publications

References 11 publications

Iron Absorption in Patients with Chronic Renal Failure not Requiring Dialytic Therapy

Iron Absorption in Patients with Chronic Renal Failure not Requiring Dialytic Therapy

SURVIVAL OF DF32P‐LABELLED ERYTHROCYTES IN URAEMIC PATIENTS DURING EXTRACORPOREAL IRRADIATION OF THE BLOOD

Iron Metabolism and Red Cell Survival in Uremic Patients

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SURVIVAL OF DF³²P‐LABELLED ERYTHROCYTES IN URAEMIC PATIENTS DURING EXTRACORPOREAL IRRADIATION OF THE BLOOD