Iron Absorption in Patients with Chronic Renal Failure not Requiring Dialytic Therapy

Milman, Nils; Larsen, Lars E.

doi:10.1111/j.0954-6820.1975.tb19583.x

Cited by 10 publications

(3 citation statements)

References 27 publications

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“…The poor correlations between stainable marrow iron and serum iron, plasma TIBC and transferrin saturation are consistent with observations from our previous studies (18,19,20). In part this could be explained by the inaccuracy of the semiquantitative histochemical method employed in the assessment of marrow iron stores.…”

Section: Discussionsupporting

confidence: 90%

“…However, calculations on the bile concentration of oxytetracycline (24) compared to the iron test dose render it probable that the influence on absorption is negligible. The plasma transferrin values were subnormal in the RPD patients, and lower than in the previously investigated non-dialysed and hemodialysed uremic subjects (18,19). These very low transferrin levels are probably caused by a restricted protein intake in combination with transferrin losses during dialysis (2) and through the gastrointestinal tract (14).…”

Section: Discussionmentioning

confidence: 83%

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Iron Absorption and Iron Status in Patients with Chronic Uremia on Regular Peritoneal Dialysis

Milman

Christensen

Bartels

et al. 1979

Journal of Internal Medicine

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ABSTRACT. Gastrointestinal iron absorption was measured by whole body counting in 18 patients on regular peritoneal dialysis. Ten patients received regular oral iron treatment prior to the study (iron treated group), 8 patients did not receive iron treatment (non‐iron treated group). Whole body retention 14 days after oral administration of 10 μCi 59Fe together with a carrier dose of 10 mg Fe2+ was used as an estimate of absorption. The erythrocyte iron incorporation, i.e. the percentage of administered 59Fe incorporated into the total erythrocyte mass, was measured. Geometric mean iron absorption in the non‐iron treated groups was 7.4±3.3 (S.D.) % and in the iron treated group 2.8±2.5% (p>0.01). Absorption in the non‐iron treated group did not differ significantly from the value in a normal control group (p<0.3). Absorption in the iron treated group was distinctly lower than in the controls (p>0.01), due to the high iron supplementation. Several patients in the non‐iron treated group had latent or overt iron deficiency, while patients in the iron treated group had satisfactory iron status. The correlation between iron absorption and erythrocyte iron incorporation was highly significant (r=0.95, p>0.001). Peritoneal dialysis patients on the whole have a normally functioning iron absorption. However, due to increased iron losses and insufficient dietary iron intake, the maintenance of a satisfactory iron balance implies an adequate oral iron supplementation.

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Section: Discussionsupporting

confidence: 90%

Section: Discussionmentioning

confidence: 83%

Iron Absorption and Iron Status in Patients with Chronic Uremia on Regular Peritoneal Dialysis

Milman

Christensen

Bartels

et al. 1979

Journal of Internal Medicine

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“…Furthermore, the protiin-restricted diet of these patients has a low iron content. Accordingly there exists a basic need for iron supplementation, as previously emphasized (10,11,12).…”

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confidence: 91%

Serum Ferritin and Bone Marrow Iron in Non‐Dialysis, Peritoneal Dialysis and Hemodialysis Patients with Chronic Renal Failure

Milman

Christensen

Pedersen

et al. 1980

Journal of Internal Medicine

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Serum ferritin was measured by immunoradiometric assay, and stainable bone marrow iron was assessed semiquantitatively in 38 patients (19 8 , 19 9 ) with chronic renal failure (7 nondialysed uremic patients, 14 patients on regular peritoneal dialysis and 17 patients on regular hemodialysis). Serum ferritin was also measured in 60 healthy subjects (30 6,30 0 ) . There was a good correlation @<0.001) between serum ferritin and marrow iron in the total group of uremic patients.Patients without stainable marrow iron (n =19) had a geometric mean serum ferritin of 51 ng/d (range 6-136), mean serum ferritin in patients with "normal" marrow iron (n=14) was 326 n g / d (range 112-1 120) and in patients with slightly increased marrow iron (n =5) 634 ndml (range 480-960). Male patients had higher mean serum femtin (244 ng/ml) and higher marrow iron score than female patients (76 mg/ml) @<0.01). All patients had higher mean serum ferritin (141 ng/ml, range 6-1 120) than the healthy subjects (46 ng/ml, range 5-285) @<0.001). Patients with serum ferritin levels of 4 1 2 n g / d had no stainable marrow iron, while those with fenitin levels of >136 n g / d had adequate marrow iron stores. The serum fenitin concentration appears to be a reliable indicator of stainable marrow iron content in uremic subjects. Regular monitoring of serum ferritin may be a guide to appropriate iron supplementation and reduces the need for repeated marrow punctures in the assessment of iron status in chronic renal failure.

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Ätiologie, Diagnostik und Dimensionierung der Therapie des Eisenmangels

Heinrich

1978

Probleme Der Erythrozytopoese, Granulozytopoese Und Des Malignen Melanoms

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Iron Absorption in Patients with Chronic Renal Failure not Requiring Dialytic Therapy

Cited by 10 publications

References 27 publications

Iron Absorption and Iron Status in Patients with Chronic Uremia on Regular Peritoneal Dialysis

Iron Absorption and Iron Status in Patients with Chronic Uremia on Regular Peritoneal Dialysis

Serum Ferritin and Bone Marrow Iron in Non‐Dialysis, Peritoneal Dialysis and Hemodialysis Patients with Chronic Renal Failure

Ätiologie, Diagnostik und Dimensionierung der Therapie des Eisenmangels

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